Novel Helical Trp- and Arg-Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes [0.03%]
新型螺旋型 tryptophan-和 arginine-富集抗菌肽靠近膜表面并使脂质模型膜变刚性
Saheli Mitra,Mark Coopershlyak,Yunshu Li et al.
Saheli Mitra et al.
Antibiotics are losing effectiveness as bacteria become resistant to conventional drugs. To find new alternatives, antimicrobial peptides (AMPs) are rationally designed with different lengths, charges, hydrophobicities (H), and hydrophobic ...
Mechanisms by Which Liposomes Improve Inhaled Drug Delivery for Alveolar Diseases [0.03%]
脂质体改善肺部给药治疗肺泡疾病的机制分析
Laura T Ferguson,Xiaonan Ma,Jacob W Myerson et al.
Laura T Ferguson et al.
Diseases of the pulmonary alveolus, such as pulmonary fibrosis, are leading causes of morbidity and mortality, but exceedingly few drugs are developed for them. A major reason for this gap is that after inhalation, drugs are quickly whisked...
Blood-brain barrier remodeling in an organ-on-a-chip device shows Dkk1 to be a regulator of early metastasis [0.03%]
一种基于芯片的器官模型展示了WNT信号通路中的DKK1调节早期转移的作用及其对血脑屏障重塑的影响
Trisha M Westerhof,Benjamin A Yang,Nathan M Merill et al.
Trisha M Westerhof et al.
Brain metastases are the most lethal progression event, in part because the biological processes underpinning brain metastases are poorly understood. There is a paucity of realistic models of metastasis, as current in vivo murine models are...
Outer Membrane Vesicle-Coated Nanoparticle Vaccine Protects Against Acinetobacter baumannii Pneumonia and Sepsis [0.03%]
包被外膜囊泡的纳米颗粒疫苗对预防鲍曼不动杆菌肺炎和脓毒症有效
Elisabet Bjanes,Jiarong Zhou,Tariq Qayum et al.
Elisabet Bjanes et al.
The highly multidrug-resistant (MDR) Gram-negative bacterial pathogen Acinetobacter baumannii is a top global health priority where an effective vaccine could protect susceptible populations and limit resistance acquisition. Outer membrane ...
Delivery route considerations for designing antigen-specific biomaterial strategies to combat autoimmunity [0.03%]
针对自身免疫设计抗原特异性生物材料策略的输送路径考虑事项
Marian A Ackun-Farmmer,Christopher M Jewell
Marian A Ackun-Farmmer
Disease modifying drugs and biologics used to treat autoimmune diseases, although promising, are non-curative. As the field moves towards development of new approaches to treat autoimmune disease, antigen-specific therapies immunotherapies ...
Hysteresis-free and high sensitivity strain sensing of ionically conductive hydrogels [0.03%]
无迟滞回线且灵敏度高的离子导电水凝胶应变传感
Jiwoo Song,Chenchen Mou,Gaurav Balakrishnan et al.
Jiwoo Song et al.
Hydrogels are promising materials for soft and implantable strain sensors owing to their large compliance (E500%) compared to other polymer networks. Further, hydrogels can be functionalized to seamlessly integrate with many types of tissue...
Surface Modification of Erythrocytes with Lipid Anchors: Structure-Activity Relationship for Optimal Membrane Incorporation, in vivo Retention, and Immunocompatibility [0.03%]
红细胞表面的脂质锚结构改造：对于优化膜整合、体内保留和免疫相容性的结构活性关系
Hanmant Gaikwad,Guankui Wang,Yue Li et al.
Hanmant Gaikwad et al.
Red blood cells (RBCs) are natural carriers for sustained drug delivery, imaging, and in vivo sensing. One of the popular approaches to functionalize RBCs is through lipophilic anchors, but the structural requirements for anchor stability a...
Isolation of circulating tumor cells to diagnose melanoma and evaluate the efficacy of surgical resection using melanoma-specific microsystem [0.03%]
利用黑素瘤特异性的微系统分离循环肿瘤细胞以诊断黑素瘤和评估手术切除的疗效
Yoon-Tae Kang,Anusha Mutukuri,Thomas Hadlock et al.
Yoon-Tae Kang et al.
Melanoma is one of the most aggressive skin cancers due to its potential to metastasize widely in the body. The risk of metastasis is increased with later detection and increased thickness of the primary lesion, thus early identification an...
Personalized Scaffolds for Diabetic Foot Ulcer Healing Using Extracellular Matrix from Induced Pluripotent Stem-Reprogrammed Patient Cells [0.03%]
使用诱导多能干细胞重组的患者细胞的细胞外基质为糖尿病足溃疡愈合个性化支架
Francesco Santarella,Ronaldo Jose Farias Correa do Amaral,Mark Lemoine et al.
Francesco Santarella et al.
Diabetic foot ulcers (DFU) are chronic wounds sustained by pathological fibroblasts and aberrant extracellular matrix (ECM). Porous collagen-based scaffolds (CS) have shown clinical promise for treating DFUs but may benefit from functional ...
Injectable Microporous Annealed Particle Hydrogel Based on Guest-Host-Interlinked Polyethylene Glycol Maleimide Microgels [0.03%]
基于客主交联聚马来酸乙二醇酯微凝胶的可注射微孔退火颗粒水凝胶
Adrienne E Widener,Senthilkumar Duraivel,Thomas E Angelini et al.
Adrienne E Widener et al.
Microporous annealed particle (MAP) hydrogels have emerged as a versatile biomaterial platform for regenerative medicine. MAP hydrogels have been used for the delivery of cells and organoids but often require annealing post injection by an ...