Engineering Tough and Elastic Polyvinyl Alcohol-Based Hydrogel with Antimicrobial Properties [0.03%]
一种具有抗菌性能的既坚韧又富弹性的聚乙烯醇水凝胶基工程材料
Avijit Baidya,Annabella Budiman,Saumya Jain et al.
Avijit Baidya et al.
Hydrogels have been extensively used for tissue engineering applications due to their versatility in structure and physical properties, which can mimic native tissues. Although significant progress has been made towards designing hydrogels ...
Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer [0.03%]
靶向CD8的近红外发光纳米探针及在乳腺癌模型中细胞毒性T淋巴细胞的成像研究
Jay V Shah,Jake N Siebert,Xinyu Zhao et al.
Jay V Shah et al.
Checkpoint immunotherapy has made great strides in the treatment of solid tumors, but many patients do not respond to immune checkpoint inhibitors. Identification of tumor-infiltrating cytotoxic T cells (CTLs) has the potential to stratify ...
A Multivalent DNA Nanoparticle/Peptide Hybrid Molecular Modality for the Modulation of Protein-Protein Interactions in the Tumor Microenvironment [0.03%]
一种用于调节肿瘤微环境中蛋白质-蛋白质相互作用的多价DNA纳米颗粒/肽混合分子模态
Jessica A Roman,Michael Y Girgis,Rocìo S Prisby et al.
Jessica A Roman et al.
Despite success in the treatment of some blood cancers and melanoma, positive response to immunotherapies remains disappointingly low in the treatment of solid tumors. The context of the molecular crosstalk within the tumor microenvironment...
Parallelized Immunomagnetic Isolation of Basophils Directly from Whole Blood [0.03%]
血液样本中 basophil细胞的平行免疫磁性分离法
Justin Myles,Nicolas Castaño,Sungu Kim et al.
Justin Myles et al.
Basophils are the rarest circulating white blood cells (WBCs), but they play important roles in allergic disorders and other diseases. To enhance diagnostic capabilities, it would be desirable to isolate and analyze basophils efficiently fr...
Engineered extracellular vesicles from human skin cells induce pro-β-cell conversions in pancreatic ductal cells [0.03%]
人皮肤细胞工程外泌体诱导胰管细胞转化为β细胞样的细胞簇
Lilibeth Ortega-Pineda,Elizabeth Guilfoyle,Maria Angelica Rincon-Benavides et al.
Lilibeth Ortega-Pineda et al.
Direct nuclear reprogramming has the potential to enable the development of β cell replacement therapies for diabetes that do not require the use of progenitor/stem cell populations. However, despite their promise, current approaches to β...
Silk Fibroin Particles as Carriers in the Development of Hemoglobin-Based Oxygen Carriers [0.03%]
基于纤维蛋白颗粒的氧载体血红蛋白的研究与发展
Marisa O Pacheco,Henry M Lutz,Jostin Armada et al.
Marisa O Pacheco et al.
Oxygen therapeutics have a range of applications in transfusion medicine and disease treatment. Synthetic molecules and all-natural or semi-synthetic hemoglobin-based oxygen carriers (HBOCs) have seen success as potential circulating oxygen...
Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold [0.03%]
用于组织工程支架的植物源性玉米谷蛋白代替动物源明胶的研究
Apurva Limaye,Venkatesan Perumal,Courtney M Karner et al.
Apurva Limaye et al.
Natural biomaterials are commonly used as tissue engineering scaffolds due to their biocompatibility and biodegradability. Plant-derived materials have also gained significant interest due to their abundance and as a sustainable resource. T...
Basement Membrane Mimetic Hydrogel Cooperates with Rho-Associated Protein Kinase Inhibitor to Promote the Development of Acini-Like Salivary Gland Spheroids [0.03%]
基底膜模拟水凝胶与Rho相关蛋白质激酶抑制剂联合促进类似腺泡的唾液腺球体发育
Eric W Fowler,Robert L Witt,Xinqiao Jia
Eric W Fowler
Successful engineering of functional salivary glands necessitates the creation of cell-instructive environments for ex vivo expansion and lineage specification of primary human salivary gland stem cells (hS/PCs). Herein, basement membrane m...
Single-Exosome Counting and 3D, Subdiffraction Limit Localization Using Dynamic Plasmonic Nanoaperture Label-Free Imaging [0.03%]
动态等离子纳米孔无标记成像实现单外泌体计数及亚衍射极限定位分析
Mohammad Sadman Mallick,Ibrahim Misbah,Nareg Ohannesian et al.
Mohammad Sadman Mallick et al.
Blood-circulating exosomes as a disease biomarker have great potential in clinical applications as they contain molecular information about their parental cells. However, label-free characterization of exosomes is challenging due to their s...
Unraveling the Relevance of Tissue-Specific Decellularized Extracellular Matrix Hydrogels for Vocal Fold Regenerative Biomaterials: A Comprehensive Proteomic and In Vitro Study [0.03%]
基于蛋白质组学和体外实验的组织特异性脱细胞基质水凝胶作为声带再生生物材料的相关性研究
Mika Brown,Shirley Zhu,Lorne Taylor et al.
Mika Brown et al.
Decellularized extracellular matrix (dECM) is a promising material for tissue engineering applications. Tissue-specific dECM is often seen as a favorable material that recapitulates a native-like microenvironment for cellular remodeling. Ho...