68th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) - Meeting Abstracts: September 12-14, 2024, Regensburg, Germany [0.03%]
2024年9月12-14日德国神经病理学和神经解剖学协会第68届年度会议摘要：德国雷根斯堡
Dear colleagues, It is my pleasure and honor to host the 68th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) in Regensburg. Since the Magdeburg meeting in 2019 this is the first pure national meeting of our s...
Mesial temporal lobe epilepsy and hippocampal sclerosis associated with BRAFV600E mutant neurons in the Cornu Ammonis: an uncertain pathogenesis and a diagnostic challenge [0.03%]
BRAF V600E突变神经元与海马硬化相关的颞叶内侧癫痫：不确定的发病机制和诊断挑战
Samir Alsalek,Alexander S Himstead,Scott Self et al.
Samir Alsalek et al.
Mesial temporal lobe epilepsy (MTLE) is a common cause of seizures, and hippocampal sclerosis (HS) is the predominant subtype. BRAFV600E mutations in MTLE-HS have only been reported infrequently. Herein, we illustrate the neurologic, radiol...
Cell-in-cell phenomena of intracellular neutrophils in a recurrent pleomorphic xanthoastrocytoma [0.03%]
复发性多形黄色星形细胞瘤中的中性粒细胞胞内包涵现象
Gianna M Fote,Kamran Urgun,Jordan Davies et al.
Gianna M Fote et al.
We describe a case of a young patient with a recurrent pleomorphic xanthoastrocytoma (PXA) showing unusual cell-in-cell (CiC) phenomena. We observed mostly viable but also necrotic neutrophils engulfed within tumor cells. The recurrent tumo...
Benjamin Englert,Sigrun Roeber,Thomas Arzberger et al.
Benjamin Englert et al.
Background: The postmortem diagnostic of individuals having suffered presumptive neurodegenerative disease comprises exclusion of a prion disease, extensive brain sampling and histopathological evaluation, which are resource-intensive and t...
An optimized filter trap assay for detecting recombinant authentic tau fibrils [0.03%]
一种优化的滤过陷阱法用于检测重组天然tau淀粉样纤维
Allison R Balaj,Thomas L Rothstein,Hiroaki Kaku
Allison R Balaj
The development and optimization of the Filter Trap Assay (FTA) for the detection of authentic tau fibrils in vitro mark a pivotal advancement in the realm of tauopathy research, particularly by addressing the limitations of using polyanion...
Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours [0.03%]
与垂体神经内分泌肿瘤相关的干细胞转录因子
Kristin Astrid Øystese,Nicoleta Cristina Olarescu,Cecilia Lindskog et al.
Kristin Astrid Øystese et al.
Background: Cells with stem cell features have been described in pituitary neuroendocrine tumours (PitNETs). Transcription factors SOX2 and SOX9 are stem cell-associated markers while the pituitary progenitor marker PROP1 is involved in ant...
The presence of shrunken neurons with pyknotic nuclei in the dentate nucleus is a common postmortem change associated with autolysis of the cerebellar granular cell layer [0.03%]
齿状核中存在胞浆浓缩、核固缩的萎缩神经元是小脑颗粒细胞层自溶的一种常见的尸检改变现象
Bilge Dundar,Busranur Agac,Eyas Alzayadneh et al.
Bilge Dundar et al.
Malignant glioma in L-2-Hydroxyglutaric Aciduria: thorough molecular characterization of a case and literature review [0.03%]
L-2-羟基谷氨酸尿症相关的恶性胶质瘤：一例报告及文献回顾
Fleur Cordier,Pieter Wesseling,Bastiaan B J Tops et al.
Fleur Cordier et al.
L-2-hydroxyglutaric aciduria (L-2-HGA) is a rare neurometabolic disorder characterized by accumulation of L2-hydroxyglutarate (L-2-HG) due to mutations in the L2HGDH gene. L-2-HGA patients have a significantly increased lifetime risk of cen...
Brainstem inflammation in sudden unexpected death in infancy and childhood (SIDS/SUDC) [0.03%]
婴儿和儿童不明原因猝死（SIDS/SUDC）中的脑干炎症
Herbert Budka,Daniele U Risser,Fabio C Monticelli
Herbert Budka
Andrew T McKenzie,Oge Nnadi,Kat D Slagell et al.
Andrew T McKenzie et al.
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized. As...