The presence of shrunken neurons with pyknotic nuclei in the dentate nucleus is a common postmortem change associated with autolysis of the cerebellar granular cell layer [0.03%]
齿状核中存在胞浆浓缩、核固缩的萎缩神经元是小脑颗粒细胞层自溶的一种常见的尸检改变现象
Bilge Dundar,Busranur Agac,Eyas Alzayadneh et al.
Bilge Dundar et al.
Malignant glioma in L-2-Hydroxyglutaric Aciduria: thorough molecular characterization of a case and literature review [0.03%]
L-2-羟基谷氨酸尿症相关的恶性胶质瘤：一例报告及文献回顾
Fleur Cordier,Pieter Wesseling,Bastiaan B J Tops et al.
Fleur Cordier et al.
L-2-hydroxyglutaric aciduria (L-2-HGA) is a rare neurometabolic disorder characterized by accumulation of L2-hydroxyglutarate (L-2-HG) due to mutations in the L2HGDH gene. L-2-HGA patients have a significantly increased lifetime risk of cen...
Brainstem inflammation in sudden unexpected death in infancy and childhood (SIDS/SUDC) [0.03%]
婴儿和儿童不明原因猝死（SIDS/SUDC）中的脑干炎症
Herbert Budka,Daniele U Risser,Fabio C Monticelli
Herbert Budka
Andrew T McKenzie,Oge Nnadi,Kat D Slagell et al.
Andrew T McKenzie et al.
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized. As...
Ingmar Blümcke
Ingmar Blümcke
Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understa...
Heterogeneity of DNA methylation profiles and copy number alterations in 10782 adult-type glioblastomas, IDH-wildtype [0.03%]
10782例成人型胶质母细胞瘤DNA甲基化谱及IDH野生型拷贝数改变的异质性分析
David E Reuss,Daniel Schrimpf,Asan Cherkezov et al.
David E Reuss et al.
The morphological patterns leading to the diagnosis of glioblastoma may also commonly be observed in several other distinct tumor entities, which can result in a mixed bag of tumors subsumed under this diagnosis. The 2021 WHO Classification...
Searching for a cut-off point for p53 immunohistochemistry as evidence of TP53 mutations [0.03%]
寻找p53免疫组化作为TP53突变证据的临界值
Ilay Caliskan,Rufei Lu,Cristine Szu Lyn Ding et al.
Ilay Caliskan et al.
HIV and COVID-19: two pandemics with significant (but different) central nervous system complications [0.03%]
HIV和COVID-19：两种具有显著（但不同）中枢神经系统并发症的传染病
Shino Magaki,Ting Zhang,Karam Han et al.
Shino Magaki et al.
Human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause significant neurologic disease. Central nervous system (CNS) involvement of HIV has been extensively studied, with well-documented inv...
Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of vessel-associated mural cells in glioblastoma impacts tumor angiogenesis [0.03%]
阻断胶质母细胞瘤中TGF-β和上皮间充质转化(EMT)介导的血管相关壁细胞活化影响肿瘤血管生成
Luisa Merk,Katja Regel,Hermann Eckhardt et al.
Luisa Merk et al.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. GBM displays excessive and unfunctional vascularization which may, among others, be a reason for its devastating prognosis. Pericytes have been identified as the...