Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain [0.03%]
基于质谱成像的解释型机器学习揭示了小鼠大脑的生化景观
Jacob Gildenblat,Jorunn Stamnas,Jens Pahnke
Jacob Gildenblat
Recent computational advances in mass spectrometry imaging (MSI) now enable unprecedented insight into organ-wide molecular composition and functional architecture. Here, we present the first high-resolution molecular-computational atlas of...
Bilateral optic perineuritis with vestibulocochlear involvement: revisiting a rarely performed biopsy [0.03%]
双侧视神经鞘炎伴前庭耳蜗神经受累：重新审视一种很少进行的活检术
Katrina J Jiang,Marianne E Yassa,Saad Awan et al.
Katrina J Jiang et al.
Why it should be "Alzheimer disease" rather than "Alzheimer's disease" [0.03%]
为什么应该使用“阿尔茨海默病”而不是“阿尔茨海默氏病”
Cinthya Aguero,C Zachary Klein,Georg Haase
Cinthya Aguero
The terms "Alzheimer's disease" and "Alzheimer disease" are often used interchangeably in the biomedical literature. Yet this seemingly minor grammatical difference carries implications that extend beyond style: the possessive form, marked ...
Robust immunohistochemical detection of α-synuclein, tau and amyloid-β in human brain tissue archived for up to 78 years [0.03%]
长达78年的存档人脑组织中α-突触核蛋白、tau和淀粉样蛋白-β的免疫组化检测方法优化
Mie Kristine Just,Kristina Bang Christensen,Martin Wirenfeldt et al.
Mie Kristine Just et al.
Objective: Brain branks preserve extensive material relevant to neurodegenerative disease research. As these collections age, tissue becomes archival, raising the question of whether long-term fixed and stored human brain tissue remains sui...
Michael Farrell
Michael Farrell
Form follows function: morphology as a map of mechanisms in neurodegenerative disease pathology [0.03%]
形式服从功能：神经退行性疾病病理机制的形态学地图
Edward B Lee
Edward B Lee
Across neurodegenerative diseases, the shape and spatial organization of pathology carry rich mechanistic information. Vacuoles, spongiosis, oligodendroglial coiled bodies, dendritic dystrophic neurites, amyloid plaque compactness, and phas...
The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration [0.03%]
脑垃圾的形状：神经退行性病变中细胞残体形态之谜
David V Forrest
David V Forrest
This meditation with apologies by a psychiatrist who is not a neuropathologist but attends CPCs of movement disorder patients speculates about how microscopic mechanical processes produce the variety of cellular neuropathological forms, whi...
Trends in neuropathology training in Sub-Saharan Africa - current curricula, resource gaps, and the potential of virtual microscopy and telemedicine [0.03%]
东非神经病理学培训趋势-现行课程、资源差距及虚拟显微镜和远程医学的潜力
Habiblah Jagunmolu,Emmanuel Oyetola,Kamil Ajagbe et al.
Habiblah Jagunmolu et al.
Introduction: Neuropathology is important in the diagnosis of neurologic and neuro-oncologic diseases. But despite its immense importance, it remains underrepresented in medical training across different parts of Sub-Saharan Africa. Trainin...
Central nervous system schwannoma, VGLL-fused (EWSR1::VGLL1 fusion) with neuroblastoma-like cell dense areas in the frontal lobe of a young man with schwannomatosis due to a germline LZTR1 mutation [0.03%]
由于LZTR1种系突变的施万细胞瘤病患者的中枢神经系统的施万细胞瘤（EWSR1::VGLL1融合）， frontal lobe 中出现类似神经母细胞瘤密集细胞区域（发生在一位年轻男性身上）
David G Munoz,Sunit Das,Ju-Yoon Yoon et al.
David G Munoz et al.
We report a central nervous system schwannoma, VGLL-fused in a young man's frontal lobe. Somatic abnormalities included an EWSR1::VGLL1 fusion, which incorporated the entire translated region of VGLL1, but excluded most domains of EWSR1. Th...