Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment [0.03%]
脑血管病病变具有累积性并受血管危险因素和认知障碍影响
John L Robinson,Hayley Richardson,Sharon X Xie et al.
John L Robinson et al.
Cerebrovascular lesions are prevalent in late life and frequently co-occur but the relationship to cognitive impairment is complicated by the lack of consensus around which lesions represent hallmark pathologies for vascular impairment, par...
Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts [0.03%]
人和小鼠来源的可溶性脑匀浆偏爱性地在新生小鼠宿主中诱发弥散型淀粉样蛋白斑病理病变
Brenda D Moore,Yona Levites,Guilian Xu et al.
Brenda D Moore et al.
Background: Seeding of pathology related to Alzheimer's disease (AD) and Lewy body disease (LBD) by tissue homogenates or purified protein aggregates in various model systems has revealed prion-like properties of these di...
Neuropathology Studies of Dementia in US Persons other than Non-Hispanic Whites [0.03%]
美国非西班牙裔白人以外的痴呆症神经病理学研究
My-le Nguyen,Emily Z Huie,Rachel A Whitmer et al.
My-le Nguyen et al.
Alzheimer's disease (AD) and vascular dementia are two of the most prevalent dementias that afflict the aging population in the United States (US). Studies have made great strides in understanding the neuropathology of these diseases; howev...
Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits [0.03%]
在没有炎症或代谢缺陷的情况下，抑制线粒体丙酮酸载体不能改善突触核蛋白病
Wouter Peelaerts,Liza Bergkvist,Sonia George et al.
Wouter Peelaerts et al.
Epidemiological studies suggest a link between type-2 diabetes and Parkinson's disease (PD) risk. Treatment of type-2 diabetes with insulin sensitizing drugs lowers the risk of PD. We previously showed that the insulin sensitizing drug, MSD...
Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters [0.03%]
利用ABCA转运调节剂获得新型阿尔茨海默病诊断和治疗方法的策略
Jens Pahnke,Pablo Bascuñana,Mirjam Brackhan et al.
Jens Pahnke et al.
Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC tr...
Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy [0.03%]
慢性创伤性脑病早期阶段沟底与回峰区域差异基因表达谱分析
Jonathan D Cherry,Filisia Agus,Erin Dixon et al.
Jonathan D Cherry et al.
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative tauopathy found in individuals with a history of repetitive head impacts (RHI). Previous work has demonstrated that neuroinflammation is involved in CTE pathogenesis,...
Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of Aβ plaques in Alzheimer's disease [0.03%]
激活的小胶质细胞聚类发生在阿尔茨海默病中Aβ斑块演化过程中神经元退行性变体形成的早期事件
Patrick Jarmo Paasila,Danielle Suzanne Davies,Greg Trevor Sutherland et al.
Patrick Jarmo Paasila et al.
Alzheimer's disease (AD) is a late-onset disease that has proved difficult to model. Microglia are implicated in AD, but reports vary on precisely when and how in the sequence of pathological changes they become involved. Here, post-mortem ...
Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS [0.03%]
神经中间丝包涵病可能被错误地分类为FTLD-FUS亚型之一
Kevin F Bieniek,Keith A Josephs,Wen-Lang Lin et al.
Kevin F Bieniek et al.
Background: The majority of cases of frontotemporal lobar degeneration (FTLD) are characterized by focal cortical atrophy with an underlying tau or TDP-43 proteinopathy. A subset of FTLD cases, however, lack tau and TDP-4...
The 'ACCIDENTAL NEUROPATHOLOGIST'-PERSPECTIVES on 40 years in Neuropathology [0.03%]
《偶然的神经病理学家》——神经病理学四十年回顾与思考
Harry V Vinters
Harry V Vinters
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update [0.03%]
新型冠状病毒的神经病理学（神经新冠）：临床病理学更新
Jerry J Lou,Mehrnaz Movassaghi,Dominique Gordy et al.
Jerry J Lou et al.
Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health crisis in the early 21stcentury. Its causative agent, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), is an enveloped single stranded positive-sense...