Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters [0.03%]
利用ABCA转运调节剂获得新型阿尔茨海默病诊断和治疗方法的策略
Jens Pahnke,Pablo Bascuñana,Mirjam Brackhan et al.
Jens Pahnke et al.
Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC tr...
Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy [0.03%]
慢性创伤性脑病早期阶段沟底与回峰区域差异基因表达谱分析
Jonathan D Cherry,Filisia Agus,Erin Dixon et al.
Jonathan D Cherry et al.
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative tauopathy found in individuals with a history of repetitive head impacts (RHI). Previous work has demonstrated that neuroinflammation is involved in CTE pathogenesis,...
Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of Aβ plaques in Alzheimer's disease [0.03%]
激活的小胶质细胞聚类发生在阿尔茨海默病中Aβ斑块演化过程中神经元退行性变体形成的早期事件
Patrick Jarmo Paasila,Danielle Suzanne Davies,Greg Trevor Sutherland et al.
Patrick Jarmo Paasila et al.
Alzheimer's disease (AD) is a late-onset disease that has proved difficult to model. Microglia are implicated in AD, but reports vary on precisely when and how in the sequence of pathological changes they become involved. Here, post-mortem ...
Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS [0.03%]
神经中间丝包涵病可能被错误地分类为FTLD-FUS亚型之一
Kevin F Bieniek,Keith A Josephs,Wen-Lang Lin et al.
Kevin F Bieniek et al.
Background: The majority of cases of frontotemporal lobar degeneration (FTLD) are characterized by focal cortical atrophy with an underlying tau or TDP-43 proteinopathy. A subset of FTLD cases, however, lack tau and TDP-4...
The 'ACCIDENTAL NEUROPATHOLOGIST'-PERSPECTIVES on 40 years in Neuropathology [0.03%]
《偶然的神经病理学家》——神经病理学四十年回顾与思考
Harry V Vinters
Harry V Vinters
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update [0.03%]
新型冠状病毒的神经病理学（神经新冠）：临床病理学更新
Jerry J Lou,Mehrnaz Movassaghi,Dominique Gordy et al.
Jerry J Lou et al.
Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health crisis in the early 21stcentury. Its causative agent, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), is an enveloped single stranded positive-sense...
Aβ Plaques [0.03%]
β淀粉样蛋白斑块
Lary C Walker
Lary C Walker
Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them include massed, fibrillar polymers of the Aβ protein referred to as...
Neuronal Transcriptome from C9orf72 Repeat Expanded Human Tissue is Associated with Loss of C9orf72 Function [0.03%]
来自C9orf72重复扩展的人体组织的神经元转录组与C9orf72功能丧失有关
Elaine Y Liu,Jenny Russ,Edward B Lee
Elaine Y Liu
A hexanucleotide G4C2 repeat expansion in C9orf72 is the most common genetic cause of familial and sporadic cases of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The mutation is associated with a reduction of C...
Just 40 years ago, Europe was divided into the Eastern communist bloc, which included the Czechoslovak Socialist Republic (ČSSR) and was dominated by the now historical Soviet Union, and the Western bloc comprising democracies such as Aust...
Immersing the brain in a solution containing formaldehyde is a commonly used method for preserving the structure of human brain tissue in brain banking. However, there are questions about the quality of preservation using this method, as fo...