Neuropathology through the ages - My life between neurology and neuropathology [0.03%]
穿越时代的神经病理学——我穿梭于神经病学和神经病理学之间的一生
Kurt A Jellinger
Kurt A Jellinger
János Bencze,Woosung Seo,Abdul Hye et al.
János Bencze et al.
Dementia is one of the major burdens of our aging society. According to certain predictions, the number of patients will double every 20 years. Although Alzheimer's disease (AD), as the most frequent neurodegenerative dementia, has been ext...
Margaret Miriam Esiri
Margaret Miriam Esiri
Pieter Wesseling
Pieter Wesseling
This article briefly discusses 10 topics that were selected by the author as top 10 discoveries published in 2019 in the broader field of neuro-oncological pathology (so including neurosciences as well as clinical neuro-oncology but with im...
Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment [0.03%]
脑血管病病变具有累积性并受血管危险因素和认知障碍影响
John L Robinson,Hayley Richardson,Sharon X Xie et al.
John L Robinson et al.
Cerebrovascular lesions are prevalent in late life and frequently co-occur but the relationship to cognitive impairment is complicated by the lack of consensus around which lesions represent hallmark pathologies for vascular impairment, par...
Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts [0.03%]
人和小鼠来源的可溶性脑匀浆偏爱性地在新生小鼠宿主中诱发弥散型淀粉样蛋白斑病理病变
Brenda D Moore,Yona Levites,Guilian Xu et al.
Brenda D Moore et al.
Background: Seeding of pathology related to Alzheimer's disease (AD) and Lewy body disease (LBD) by tissue homogenates or purified protein aggregates in various model systems has revealed prion-like properties of these di...
Neuropathology Studies of Dementia in US Persons other than Non-Hispanic Whites [0.03%]
美国非西班牙裔白人以外的痴呆症神经病理学研究
My-le Nguyen,Emily Z Huie,Rachel A Whitmer et al.
My-le Nguyen et al.
Alzheimer's disease (AD) and vascular dementia are two of the most prevalent dementias that afflict the aging population in the United States (US). Studies have made great strides in understanding the neuropathology of these diseases; howev...
Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits [0.03%]
在没有炎症或代谢缺陷的情况下，抑制线粒体丙酮酸载体不能改善突触核蛋白病
Wouter Peelaerts,Liza Bergkvist,Sonia George et al.
Wouter Peelaerts et al.
Epidemiological studies suggest a link between type-2 diabetes and Parkinson's disease (PD) risk. Treatment of type-2 diabetes with insulin sensitizing drugs lowers the risk of PD. We previously showed that the insulin sensitizing drug, MSD...