Studies on inflammation and stroke provide clues to pathomechanism of central nervous system involvement in COVID-19 [0.03%]
关于炎症和中风的研究为COVID-19中枢神经系统参与的发病机制提供线索
Ádám Dénes,Stuart M Allan,Tibor Hortobágyi et al.
Ádám Dénes et al.
Mara Dierssen
Mara Dierssen
Developmental brain disorders, a highly heterogeneous group of disorders with a prevalence of around 3% of worldwide population, represent a growing medical challenge. They are characterized by impaired neurodevelopmental processes leading ...
Kurt A Jellinger
Kurt A Jellinger
Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder of uncertain etiology, clinically characterized by various combinations of Levo-dopa-unresponsive parkinsonism, and cerebellar, motor, and autonomic dysfunctio...
Werner Jänisch
Werner Jänisch
Adrien de Guilhem de Lataillade,Thibaud Lebouvier,Wendy Noble et al.
Adrien de Guilhem de Lataillade et al.
An accumulating body of literature has emerged in the past 25 years to show that Parkinson's disease (PD) is not only a disorder of the brain but also of the gastrointestinal tract and more generally of the gut-brain axis. Gastrointestinal ...
Marta Margeta
Marta Margeta
This review highlights ten important advances in the neuromuscular disease field that either were first reported in 2019, or have reached a broad consensus during that year. The overarching topics include (i) new / emerging diseases; (ii) a...
Daniel P Perl
Daniel P Perl
Neurotrauma represents a major public health problem and is one of the leading causes of death and disability worldwide. Despite its high prevalence, there are major gaps in our understanding of the underlying pathophysiology leading to the...
Treatment of autoimmune encephalomyelitis with a histone deacetylase inhibitor [0.03%]
组蛋白去乙酰化酶抑制剂治疗自身免疫性脑脊髓炎
Arathi K Jayaraman,Karen Avgush,Rashad Kulam et al.
Arathi K Jayaraman et al.
We have previously shown that treatment of female NOD mice with a potent nonselective histone deacetylase inhibitor attenuated experimental autoimmune encephalomyelitis, a model for progressive multiple sclerosis. Herein we show that immuni...
Hans Lassmann
Hans Lassmann
Ten neuropathological studies, published in 2019, are discussed, which address important aspects of neuroimmunology and inflammatory brain disease. They include topics related to new mechanisms of inflammation and immune mediated neurodegen...