Tanja Kuhlmann,Jack Antel
Tanja Kuhlmann
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the Central Nervous System (CNS). Significant progress has been made during recent years in preventing relapses by using systemic immunomodulatory or imm...
Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement? [0.03%]
SARS-CoV-2刺突蛋白在脑COVID-19微血管病变中的高尔基体定位及其与furin的相互作用：中枢神经系统受累的线索？
Susana Boluda,Karima Mokhtari,Bruno Mégarbane et al.
Susana Boluda et al.
In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative ...
Anna M Planas
Anna M Planas
The aim of this review is to highlight novel findings in 2019 in the area of neurovascular disease. Experimental studies have provided insight into disease development, molecular determinants of pathology, and putative novel therapeutic tar...
Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin [0.03%]
定量蛋白质组学分析显示脑淀粉样血管病白质中基质蛋白和簇素上调
Antigoni Manousopoulou,Ho Ming Yuen,Matthew MacGregor Sharp et al.
Antigoni Manousopoulou et al.
Aims: Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid beta (Aβ) in the walls of cerebral arterioles, arteries and capillaries. Changes in the white matter in CAA are observed as hyperintensities and dilated perivascular sp...
Kurt A Jellinger
Kurt A Jellinger
Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). Originally defined as a clinicopathological entity, it is a heterogenous, multifactorial disorder, currently referred to as th...
Loss of Ramified Microglia Precedes Axonal Spheroid Formation in Adult-Onset Leukoencephalopathy with Axonal Spheroids [0.03%]
成人发病的轴索球体白质脑病中 ramified 小胶质细胞丢失先于轴索球体形成
Murad Alturkustani,Qi Zhang,Basma AlYamany et al.
Murad Alturkustani et al.
Two different pathological mechanisms have been suggested to underlie adult-onset leukoencephalopathy with axonal spheroids (ALAS). Pathological studies have suggested that ALAS involves primary axonopathy with secondary demyelination. Howe...
John F Crary
John F Crary
As we embark on a new year of scientific inquiry in neurodegenerative disease research, it is helpful to take a look back and consider the contributions in the field with the potential to be the most impactful. The purpose of this review is...
Neuropathologists play a key role in establishing the extent of COVID-19 in human patients [0.03%]
neuropathologist在确定Covid-19对患者的损伤程度中起关键作用
Lokman Cevik,Michele Joana Alves,José Javier Otero
Lokman Cevik
SARS-CoV2 infection causes COVID-19, and represents the most emergent health care crisis of our generation. Ample evidence in the scientific literature suggests that SARS-CoV, MERS-CoV, and endemic human coronaviruses infect brain cells. We...