Kurt A Jellinger
Kurt A Jellinger
Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). Originally defined as a clinicopathological entity, it is a heterogenous, multifactorial disorder, currently referred to as th...
Loss of Ramified Microglia Precedes Axonal Spheroid Formation in Adult-Onset Leukoencephalopathy with Axonal Spheroids [0.03%]
成人发病的轴索球体白质脑病中 ramified 小胶质细胞丢失先于轴索球体形成
Murad Alturkustani,Qi Zhang,Basma AlYamany et al.
Murad Alturkustani et al.
Two different pathological mechanisms have been suggested to underlie adult-onset leukoencephalopathy with axonal spheroids (ALAS). Pathological studies have suggested that ALAS involves primary axonopathy with secondary demyelination. Howe...
John F Crary
John F Crary
As we embark on a new year of scientific inquiry in neurodegenerative disease research, it is helpful to take a look back and consider the contributions in the field with the potential to be the most impactful. The purpose of this review is...
Neuropathologists play a key role in establishing the extent of COVID-19 in human patients [0.03%]
neuropathologist在确定Covid-19对患者的损伤程度中起关键作用
Lokman Cevik,Michele Joana Alves,José Javier Otero
Lokman Cevik
SARS-CoV2 infection causes COVID-19, and represents the most emergent health care crisis of our generation. Ample evidence in the scientific literature suggests that SARS-CoV, MERS-CoV, and endemic human coronaviruses infect brain cells. We...
Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery [0.03%]
路易体障碍患者的疾病相关α-突触核蛋白可能沉积在硬脑膜中：外科手术意外传播的潜在影响
Ellen Gelpi,Naomi P Visanji,Selma Hönigschnabl et al.
Ellen Gelpi et al.
Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties. Prion diseases can be transmitted by the transplantation of cadaveric dura mater causing iat...
Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples [0.03%]
优化滤器捕获法检测脑组织样本中聚集的α-突触核蛋白
Thibauld Oullier,Alice Prigent,Guillaume Chapelet et al.
Thibauld Oullier et al.
Ferenc Garzuly
Ferenc Garzuly
Peter Lantos
Peter Lantos