Mechanistic Facets of the Competition between Cross-Coupling and Homocoupling in Supporting Ligand-Free Iron-Mediated Aryl-Aryl Bond Formations [0.03%]
无配体助剂铁介导的芳基-芳基键构建中交叉偶联和均相聚合成的竞争的机制方面
Edouard Zhou,Pablo Chourreu,Nicolas Lefèvre et al.
Edouard Zhou et al.
In the context of cross-coupling chemistry, the competition between the cross-coupling path itself and the oxidative homocoupling of the nucleophile is a classic issue. In that case, the electrophilic partner acts as a sacrificial oxidant. ...
Michał Antoszczak,Sebastian Müller,Ludovic Colombeau et al.
Michał Antoszczak et al.
Salinomycin, a natural carboxylic polyether ionophore, shows a very interesting spectrum of biological activities, including selective toxicity toward cancer stem cells (CSCs). Recently, we have developed a C20-propargylamine derivative of ...
Intramolecular Hydrogen-Bond Activation: Strategies, Benefits, and Influence in Catalysis [0.03%]
分子内氢键活化：策略、益处及对催化的影响
Andrea Guerrero-Corella,Alberto Fraile,José Alemán
Andrea Guerrero-Corella
The activation of molecules through intramolecular hydrogen-bond formation to promote chemical reactions appears as a suitable strategy in organic synthesis, especially for the preparation of chiral compounds under metal and organocatalytic...
Expeditive Synthesis of Potent C20- epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells [0.03%]
高效构建一类具有抗肿瘤干细胞活性的新型.salynmycin.C20氨基衍生物化合物库
Dominika Czerwonka,Sebastian Müller,Tatiana Cañeque et al.
Dominika Czerwonka et al.
As a continuation of our studies toward the development of small molecules to selectively target cancer stem cells (CSCs), a library of 18 novel derivatives of salinomycin (Sal), a naturally occurring polyether ionophore, was synthesized wi...
Enantioselective Catalytic Synthesis of α-Halogenated α-Aryl-β2,2-amino Acid Derivatives [0.03%]
不对称催化合成α-卤代α-芳基-β2，2-氨基酸衍生物
Paul Zebrowski,Isabella Eder,Andreas Eitzinger et al.
Paul Zebrowski et al.
The enantioselective synthesis of a broad variety of novel differently functionalized α-halogenated α-aryl-β2,2-amino acid derivatives by means of an ammonium-salt-catalyzed asymmetric α-halogenation of isoxazolidin-5-ones was accomplis...
Covalent [2]Catenane and [2]Rotaxane Synthesis via a δ-Amino Acid Template [0.03%]
通过δ-氨基酸模板合成共价[2]索烃和[2]轮烷
Simone Pilon,Steen Ingemann Jørgensen,Jan H van Maarseveen
Simone Pilon
Despite the advances in the synthesis of mechanically interlocked molecules, a generally applicable approach to interlocked natural products, such as lasso peptides, is yet to be formulated. While amino acid sequences have been introduced i...
Substituent Effects Provide Access to Tetrasubstituted Ring-Opening Olefin Metathesis of Bicyclo[4.2.0]oct-6-enes [0.03%]
取代基效应可用于合成四取代环开环烯烃复分解反应的双环[4.2.0]辛-6-烯
Gyusaang Youn,Nicole S Sampson
Gyusaang Youn
Herein, we report the origin of unexpected reactivity of bicyclo[4.2.0]oct-6-ene substrates containing an α,β-unsaturated amide moiety in ruthenium-catalyzed alternating ring-opening metathesis polymerization reactions. Specifically, comp...
Sulfinamides constitute adaptable S(IV) intermediates with a sulfur stereocenter, having emerging interest in divergent synthesis of high-valent S(VI) functional bioisosteres. Recent years have witnessed the strategic development of mild an...