Hidden β-γ Dehydrogenation Products in Long-Chain Fatty Acid Oxidation Unveiled by NMR: Implications on Lipid Metabolism [0.03%]
揭开长链脂肪酸氧化中间体β-γ脱氢化产物的真面目：核磁共振一阶段代谢流分析法的建立及应用
Simone Fabbian,Beatrice Masciovecchio,Elisabetta Schievano et al.
Simone Fabbian et al.
We present a comprehensive analysis of the initial α,β-dehydrogenation step in long-chain fatty acid β-oxidation (FAO). We focused on palmitoyl-CoA oxidized by two mitochondrial acyl-CoA dehydrogenases, very-long-chain acyl-CoA dehydroge...
Kang Lu,Yixian Wang,Chenhang Wang et al.
Kang Lu et al.
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that regulates various physiological functions, and its abnormal levels have been closely linked to the onset and progression of numerous diseases including renal cell carci...
Antimicrobial Efficacy of 1,2,3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis [0.03%]
含有1,2,3-三氮唑的吲哚-吡唑酮对耐药ESKAPE病原体的抗菌功效：设计与合成
Dipti B Upadhyay,Jaydeep A Mokariya,Paras J Patel et al.
Dipti B Upadhyay et al.
In the current study, we report the synthesis of novel 4-((1-((1H-1,2,3-triazole-4-yl)methyl)-1H-indol-3-yl)methylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazole-3-one derivatives 5a-o. The compounds were prepared through a Knoevenagel conde...
A Reverse Transcription Nucleic-Acid-Based Barcoding System for In Vivo Measurement of Lipid Nanoparticle mRNA Delivery [0.03%]
用于测量脂质纳米颗粒mRNA递送的反向转录核酸条形码系统
Kevin C Wang,Tiana L Young,Jingan Chen et al.
Kevin C Wang et al.
Lipid nanoparticles (LNPs) are the most extensively validated clinical delivery vehicles for mRNA therapeutics, exemplified by their widespread use in the mRNA COVID-19 vaccines. The pace of lipid nanoparticle (LNP) development for mRNA the...
Disha Kashyap,Michael J Booth
Disha Kashyap
Nucleic acids have emerged as a powerful class of therapeutics. Through simple base pair complementarity, nucleic acids allow the targeting of a variety of pathologically relevant proteins and RNA molecules. However, despite the preliminary...
Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment [0.03%]
麦酚酸类似物的设计与合成在骨肉瘤癌症治疗中的应用
Patamawadee Silalai,Pimpisa Teeyakasem,Dumnoensun Pruksakorn et al.
Patamawadee Silalai et al.
Mycophenolic acid (MPA), a natural compound, was modified to new MPA analogues via the classical method of silylation and esterification. Their cytotoxicity was evaluated in vitro on four osteosarcoma cancer cell lines (MNNG/HOS, U2OS, 143B...
Simulations Reveal Unique Roles for the FXR Hinge in the FXR-RXR Nuclear Receptor Heterodimer [0.03%]
模拟揭示FXR连接区在FXR-RXR核受体异二聚体中的独特作用
Tracy Yu,Arumay Biswas,Namita Dube et al.
Tracy Yu et al.
Nuclear receptors are multidomain transcription factors whose full-length quaternary architecture is poorly described and understood. Most nuclear receptors bind DNA as heterodimers or homodimers, which could encompass a variety of arrangem...
Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression [0.03%]
用于治疗具有高水平的甲胎蛋白表达的肝癌的小干扰RNA负载阳离子脂质纳米粒的发展
Kongpop Duangchan,Nathachit Limjunyawong,Kamonlatth Rodponthukwaji et al.
Kongpop Duangchan et al.
α-Fetoprotein (AFP) is an oncogenic glycoprotein that is overexpressed in most patients with liver cancer. Moreover, it significantly affects tumorigenesis and progression, particularly by inhibiting programmed cell death or apoptosis. The...
Terminator: A Software Package for Fast and Local Optimization of His-Tag Placement for Protein Affinity Purification [0.03%]
终结者：一个用于蛋白质亲和纯化中组氨酸标签定位的快速局部优化软件包
Rokas Gerulskis,Shelley D Minteer
Rokas Gerulskis
Although the use of affinity tags can greatly improve purification of expressed enzymes, the placement of affinity tags can significantly impact the expression, solubility, and function of recombinant proteins. To facilitate the optimal des...
NIR-Responsive Black Phosphorus Nanosheet-Integrated Niosomes for Combinatorial Chemo-phototherapy of Cancers [0.03%]
NIR响应的黑磷纳米片整合而成的尼奥斯体用于癌症的化学光疗组合治疗
Rahul Kumar,Shubham Kumar Singh,Rishabh Kumar Srivastava et al.
Rahul Kumar et al.
Cancer remains one of the major challenges in the field of clinical biomedicine. There is a great deal of scope for the development of various innovative therapies. To advance in the field of cancer therapeutics, the research trend has grad...