Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context of in Vitro Bladder Epithelial Cell Infection [0.03%]
xylocaine对体外膀胱上皮细胞感染的抑菌和免疫调节作用研究
John Kerr White,Yundi Yin,Soumitra Mohanty et al.
John Kerr White et al.
The application of urinary catheters is associated with pain and discomfort. Several topical medications are available to ease catheter insertion, including xylocaine. Here we report that xylocaine, although not classified as an antibacteri...
Metabolic Probing of Sialylated Glycoconjugates with Fluorine-Selenol Displacement Reaction (FSeDR) [0.03%]
氟硒醇置换反应(FSeDR)对唾液酸化糖缀合物的代谢探针研究
Yue Zhao,Zhigang Lyu,Benjamin Prather et al.
Yue Zhao et al.
Dysregulated sialic acid biosynthesis is characteristic of the onset and progression of human diseases including hormone-sensitive prostate cancer and breast cancer. The sialylated glycoconjugates involved in this process are therefore impo...
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA [0.03%]
用于细胞内丙二酰辅酶A检测的基因编码荧光生物传感器
Brodie L Ranzau,Tiffany D Robinson,Jack M Scully et al.
Brodie L Ranzau et al.
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through protein malonylation and allosteric regulation of signaling networks. Accordingly, the production and use of malonyl-CoA is finely tuned by the c...
Antigenicity Extension: A Novel Concept Explained by the Immunogenicity of PEG [0.03%]
抗原扩展性：一个可以通过PEG的免疫原性来解释的新概念
Kouichi Shiraishi,Masayuki Yokoyama
Kouichi Shiraishi
Poly(ethylene glycol)-related immune responses have been a great concern regarding mRNA vaccination for the SARS-CoV2 virus, because PEG-lipids are an essential component for the lipid nanoparticles of mRNA vaccines. Meanwhile, no research ...
Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes [0.03%]
细胞色素P450酶催化C-N和C-S键构建的机制视角
Tai-Ping Zhou,Yakun Fan,Jinyan Zhang et al.
Tai-Ping Zhou et al.
Cytochrome P450 enzymes catalyze a large number of oxidative transformations that are responsible for natural product synthesis. Recent studies have revealed their unique ability to catalyze the formation of C-N and C-S bonds, broadening th...
Ex Vivo Delivery of mRNA to Immune Cells via a Nonendosomal Route Obviates the Need for Nucleoside Modification [0.03%]
无需核苷修饰通过非内体途径向免疫细胞递送mRNA
Bartika Ghoshal,Debajyoti Chakraborty,Manish Nag et al.
Bartika Ghoshal et al.
Base modification and the use of lipid nanoparticles are thought to be essential for efficient in vivo delivery and expression of mRNA. However, for ex vivo immune cell engineering, the need for either of the two is unclear. Previous report...
Design, Synthesis, and Evaluation of Trihalomethyl Ketone Derivatives of Neocarzilin A as Improved Antimetastatic Agents [0.03%]
设计、合成及评估 neocearlincin A 的三卤甲基酮衍生物作为改善的抗转移剂及评价
Noah M Moriarty,Annaleigh M Benton,Lauren E Gartenhaus et al.
Noah M Moriarty et al.
Vesicle Amine Transport-1 (VAT1) is a protein that is overexpressed in many cancers, including breast cancer, glioblastoma, and angiosarcoma. High VAT1 expression correlates with poor overall survival, and genetic knockout models of VAT1 in...
Innovative Dual Combination Cospray-Dried Rock Inhibitor/l-Carnitine Inhalable Dry Powder Aerosols [0.03%]
创新复方抑岩素/左旋肉碱吸入干粉气溶胶研究
Maria F Acosta,David Encinas-Basurto,Michael D Abrahamson et al.
Maria F Acosta et al.
This study introduces novel cospray-dried (Co-SD) formulations of simvastatin, a Nrf2 activator ROCK inhibitor, with l-carnitine as molecular mixtures in various molar ratios for targeted pulmonary inhalation aerosol delivery in pulmonary h...
Structural Evidence for DUF512 as a Radical S-Adenosylmethionine Cobalamin-Binding Domain [0.03%]
DUF512作为 radicalsaderadenosylmethioniner钴胺素结合域的结构证据
Bo Wang,Amy E Solinski,Matthew I Radle et al.
Bo Wang et al.
Cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) enzymes constitute a large subclass of radical SAM (RS) enzymes that use Cbl to catalyze various types of reactions, the most common of which are methylations. Most Cbl-dependent ...
An Investigation of Nirmatrelvir (Paxlovid) Resistance in SARS-CoV-2 Mpro [0.03%]
针对SARS-CoV-2 Mpro中帕克斯洛维德(Nirmatrelvir)耐药性的研究
Rasha M Yaghi,Dennis C Wylie,Collin L Andrews et al.
Rasha M Yaghi et al.
The high throughput YESS 2.0 platform was used to screen a large library of SARS-CoV-2 Mpro variants in the presence of nirmatrelvir. Of the 100 individual most prevalent mutations identified in the screen and reported here, the most common...