Disha Kashyap,Michael J Booth
Disha Kashyap
Nucleic acids have emerged as a powerful class of therapeutics. Through simple base pair complementarity, nucleic acids allow the targeting of a variety of pathologically relevant proteins and RNA molecules. However, despite the preliminary...
Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment [0.03%]
麦酚酸类似物的设计与合成在骨肉瘤癌症治疗中的应用
Patamawadee Silalai,Pimpisa Teeyakasem,Dumnoensun Pruksakorn et al.
Patamawadee Silalai et al.
Mycophenolic acid (MPA), a natural compound, was modified to new MPA analogues via the classical method of silylation and esterification. Their cytotoxicity was evaluated in vitro on four osteosarcoma cancer cell lines (MNNG/HOS, U2OS, 143B...
Simulations Reveal Unique Roles for the FXR Hinge in the FXR-RXR Nuclear Receptor Heterodimer [0.03%]
模拟揭示FXR连接区在FXR-RXR核受体异二聚体中的独特作用
Tracy Yu,Arumay Biswas,Namita Dube et al.
Tracy Yu et al.
Nuclear receptors are multidomain transcription factors whose full-length quaternary architecture is poorly described and understood. Most nuclear receptors bind DNA as heterodimers or homodimers, which could encompass a variety of arrangem...
Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression [0.03%]
用于治疗具有高水平的甲胎蛋白表达的肝癌的小干扰RNA负载阳离子脂质纳米粒的发展
Kongpop Duangchan,Nathachit Limjunyawong,Kamonlatth Rodponthukwaji et al.
Kongpop Duangchan et al.
α-Fetoprotein (AFP) is an oncogenic glycoprotein that is overexpressed in most patients with liver cancer. Moreover, it significantly affects tumorigenesis and progression, particularly by inhibiting programmed cell death or apoptosis. The...
Terminator: A Software Package for Fast and Local Optimization of His-Tag Placement for Protein Affinity Purification [0.03%]
终结者：一个用于蛋白质亲和纯化中组氨酸标签定位的快速局部优化软件包
Rokas Gerulskis,Shelley D Minteer
Rokas Gerulskis
Although the use of affinity tags can greatly improve purification of expressed enzymes, the placement of affinity tags can significantly impact the expression, solubility, and function of recombinant proteins. To facilitate the optimal des...
NIR-Responsive Black Phosphorus Nanosheet-Integrated Niosomes for Combinatorial Chemo-phototherapy of Cancers [0.03%]
NIR响应的黑磷纳米片整合而成的尼奥斯体用于癌症的化学光疗组合治疗
Rahul Kumar,Shubham Kumar Singh,Rishabh Kumar Srivastava et al.
Rahul Kumar et al.
Cancer remains one of the major challenges in the field of clinical biomedicine. There is a great deal of scope for the development of various innovative therapies. To advance in the field of cancer therapeutics, the research trend has grad...
Synthesis and Modification of Cordycepin-Phosphoramidate ProTide Derivatives for Antiviral Activity and Metabolic Stability [0.03%]
虫草素-磷酰胺酯前药衍生物的合成及改性在抗病毒活性和代谢稳定性中的应用
Aticha Thiraporn,Thanat Tiyasakulchai,Thitiphong Khamkhenshorngphanuch et al.
Aticha Thiraporn et al.
In our study, Prodrug nucleoTide (ProTide) technology was applied to cordycepin to enhance its antiviral activities and metabolic stability. Using cordycepin as starting material, we developed a synthetic method to access a series of stereo...
Cation Pretreatment Enables the Saline Stability of a Near-Infrared Sensor for Dopamine [0.03%]
阳离子预处理实现了用于检测多巴胺的近红外传感器在盐水中的稳定性
Xuewen Liu,Jing Chen,Hanxuan Wang et al.
Xuewen Liu et al.
Single-walled carbon nanotubes (SWCNTs) are wrapped with single-stranded DNA (ssDNA) to create near-infrared (NIR-II) fluorescent sensors for diverse analytes. However, the interaction between the negatively charged backbone of ssDNA and ca...
Probing the Limits of Reactant Concentration and Volume in Primitive Polyphenyllactate Synthesis and Microdroplet Assembly Processes [0.03%]
探究原始聚苯乳酸合成及微液滴组装过程中反应物浓度和体积的极限条件
Mahendran Sithamparam,Rehana Afrin,Navaniswaran Tharumen et al.
Mahendran Sithamparam et al.
Polyester microdroplets have been investigated as primitive protocell models that can exhibit relevant primitive functions such as biomolecule segregation, coalescence, and salt uptake. Such microdroplets assemble after dehydration synthesi...
Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61 [0.03%]
探索SARS-CoV-2主蛋白酶(Mpro)的可能耐药变异体与非共价临床前候选药物Mpro61的关系
Jessica R Kenneson,Christina Papini,Su Tang et al.
Jessica R Kenneson et al.
SARS-CoV-2 Mpro inhibitors, such as nirmatrelvir, have proven efficacy in clinical use. Nirmatrelvir was developed in a target-based approach against wild-type Mpro, with the anticipation that prolonged usage may cause enrichment of drug-re...