Problematic Attributions of Entropic and Hydrophobic Effects in Drug Interactions [0.03%]
药物相互作用中熵和疏水效应归属的问题分析
Hans-Jörg Schneider
Hans-Jörg Schneider
The ΔG affinity of drugs with biopolymers and the underling noncovalent interactions play an essential role in drug discovery. Supramolecular complexes can be designed for the identification and quantification of specific interactions, inc...
Augmentation of Antimicrobial Activity of Spiniferin by Introducing an Arginine Residue Toward Its Amino Terminus: A Possible Role of Cation-π Interaction [0.03%]
在Spiniferin氨基末端引入精氨酸残基增强其抗菌活性：阳离子-π作用的可能角色
Jyotshana Saroj,Rahul Dev Verma,Sariyah Akhtar et al.
Jyotshana Saroj et al.
Spiniferin is a 13-mer scorpion-origin antimicrobial peptide having poor antimicrobial activity. To augment Spiniferin's antimicrobial activity, we enhanced its net positive charge by replacing a glutamic acid residue with an arginine resid...
Unlocking the Potential of Brazilian Plant Terpenes to Combat Antimicrobial Resistance [0.03%]
巴西植物单萜类化合物对抗微生物耐药性的潜力探究
Danae K R Bardaji,Nagela B S Silva,Renata R Miranda et al.
Danae K R Bardaji et al.
The group of bacteria known as ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. are well recognized for their high virulence and pathogenicity...
Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways [0.03%]
参与生物合成途径中C-C和C-N键形成的非经典铁和α-酮戊二酸依赖性酶的发现
Yaoyao Shen,Anyi Sun,Yisong Guo et al.
Yaoyao Shen et al.
Iron and 2-oxoglutarate dependent (Fe/2OG) enzymes utilize an FeIV=O species to catalyze the functionalization of otherwise chemically inert C-H bonds. In addition to the more familiar canonical reactions of hydroxylation and chlorination, ...
Biosynthetic Pathways of Alaremycin and Its Derivative: Inhibitors of Porphobilinogen Synthase in Porphyrin Biosynthesis from Streptomyces sp. A012304 [0.03%]
来自链霉菌A012304的血红素生物合成途径中分枝杆菌素及衍生物抑制原卟啉原合成酶的生物合成途径研究
Mio Okui,Yuki Noto,Jun Kawaguchi et al.
Mio Okui et al.
The antibiotic alaremycin (5-acetamido-4-oxo-5-hexenoic acid, 1), isolated from Streptomyces sp. A012304, structurally resembles 5-aminolevulinic acid (ALA), a precursor in porphyrin biosynthesis, and inhibits porphobilinogen synthase, the ...
Paul D Goring,Amelia Newman,Christopher W Jones et al.
Paul D Goring et al.
Engineering Cell-Specific Protein Delivery Vehicles for Erythroid Lineage Cells [0.03%]
靶向红系细胞的细胞特异性蛋白递送载体工程学
Mekedlawit T Setegne,Aidan T Cabral,Anushri Tiwari et al.
Mekedlawit T Setegne et al.
Biologics such as proteins, peptides, and oligonucleotides are powerful ligands to modulate challenging drug targets that lack readily accessible and "ligandable" pockets. However, the limited membrane permeance of biologics severely restri...
ACS Bio & Med Chem Au: Introducing the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry [0.03%]
ACS生化与医药化学Au：介绍2024年生物、药物和制药化学新星奖得主
Squire J. Booker
Squire J. Booker
Nagaraju Mulpuri,Xin-Qiu Yao,Donald Hamelberg
Nagaraju Mulpuri
Allosteric regulation is a pivotal mechanism governing a wide array of cellular functions. Essential to this process is a flexible biomolecule allowing distant sites to interact through coordinated or sequential conformational shifts. Phosp...
Chromatin Immunoprecipitation Reveals p53 Binding to G-Quadruplex DNA Sequences in Myeloid Leukemia Cell Lines [0.03%]
染色质免疫沉淀显示p53结合到髓样白血病细胞系中的G四链体DNA序列中
Libuše Kratochvilová,Alessandra Dinová,Natália Valková et al.
Libuše Kratochvilová et al.
Clarifying functions of the p53 protein is a crucial aspect of cancer research. We analyzed the binding sites of p53 wild-type (WT) protein and its oncologically significant mutants and evaluated their transactivation properties using a fun...