Biosynthetic Pathways of Alaremycin and Its Derivative: Inhibitors of Porphobilinogen Synthase in Porphyrin Biosynthesis from Streptomyces sp. A012304 [0.03%]
来自链霉菌A012304的血红素生物合成途径中分枝杆菌素及衍生物抑制原卟啉原合成酶的生物合成途径研究
Mio Okui,Yuki Noto,Jun Kawaguchi et al.
Mio Okui et al.
The antibiotic alaremycin (5-acetamido-4-oxo-5-hexenoic acid, 1), isolated from Streptomyces sp. A012304, structurally resembles 5-aminolevulinic acid (ALA), a precursor in porphyrin biosynthesis, and inhibits porphobilinogen synthase, the ...
Paul D Goring,Amelia Newman,Christopher W Jones et al.
Paul D Goring et al.
Engineering Cell-Specific Protein Delivery Vehicles for Erythroid Lineage Cells [0.03%]
靶向红系细胞的细胞特异性蛋白递送载体工程学
Mekedlawit T Setegne,Aidan T Cabral,Anushri Tiwari et al.
Mekedlawit T Setegne et al.
Biologics such as proteins, peptides, and oligonucleotides are powerful ligands to modulate challenging drug targets that lack readily accessible and "ligandable" pockets. However, the limited membrane permeance of biologics severely restri...
ACS Bio & Med Chem Au: Introducing the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry [0.03%]
ACS生化与医药化学Au：介绍2024年生物、药物和制药化学新星奖得主
Squire J. Booker
Squire J. Booker
Nagaraju Mulpuri,Xin-Qiu Yao,Donald Hamelberg
Nagaraju Mulpuri
Allosteric regulation is a pivotal mechanism governing a wide array of cellular functions. Essential to this process is a flexible biomolecule allowing distant sites to interact through coordinated or sequential conformational shifts. Phosp...
Chromatin Immunoprecipitation Reveals p53 Binding to G-Quadruplex DNA Sequences in Myeloid Leukemia Cell Lines [0.03%]
染色质免疫沉淀显示p53结合到髓样白血病细胞系中的G四链体DNA序列中
Libuše Kratochvilová,Alessandra Dinová,Natália Valková et al.
Libuše Kratochvilová et al.
Clarifying functions of the p53 protein is a crucial aspect of cancer research. We analyzed the binding sites of p53 wild-type (WT) protein and its oncologically significant mutants and evaluated their transactivation properties using a fun...
Hidden β-γ Dehydrogenation Products in Long-Chain Fatty Acid Oxidation Unveiled by NMR: Implications on Lipid Metabolism [0.03%]
揭开长链脂肪酸氧化中间体β-γ脱氢化产物的真面目：核磁共振一阶段代谢流分析法的建立及应用
Simone Fabbian,Beatrice Masciovecchio,Elisabetta Schievano et al.
Simone Fabbian et al.
We present a comprehensive analysis of the initial α,β-dehydrogenation step in long-chain fatty acid β-oxidation (FAO). We focused on palmitoyl-CoA oxidized by two mitochondrial acyl-CoA dehydrogenases, very-long-chain acyl-CoA dehydroge...
Kang Lu,Yixian Wang,Chenhang Wang et al.
Kang Lu et al.
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that regulates various physiological functions, and its abnormal levels have been closely linked to the onset and progression of numerous diseases including renal cell carci...
Antimicrobial Efficacy of 1,2,3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis [0.03%]
含有1,2,3-三氮唑的吲哚-吡唑酮对耐药ESKAPE病原体的抗菌功效：设计与合成
Dipti B Upadhyay,Jaydeep A Mokariya,Paras J Patel et al.
Dipti B Upadhyay et al.
In the current study, we report the synthesis of novel 4-((1-((1H-1,2,3-triazole-4-yl)methyl)-1H-indol-3-yl)methylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazole-3-one derivatives 5a-o. The compounds were prepared through a Knoevenagel conde...
A Reverse Transcription Nucleic-Acid-Based Barcoding System for In Vivo Measurement of Lipid Nanoparticle mRNA Delivery [0.03%]
用于测量脂质纳米颗粒mRNA递送的反向转录核酸条形码系统
Kevin C Wang,Tiana L Young,Jingan Chen et al.
Kevin C Wang et al.
Lipid nanoparticles (LNPs) are the most extensively validated clinical delivery vehicles for mRNA therapeutics, exemplified by their widespread use in the mRNA COVID-19 vaccines. The pace of lipid nanoparticle (LNP) development for mRNA the...