Glycosylated N‑Acyl Phosphoethanolamines as Bacterial Food-Dependent Signaling Molecules in Caenorhabditis Nematodes [0.03%]
细菌糖基化-N酰磷脂醇胺：作为秀丽隐杆线虫中的食物依赖型信号分子
Siva Bandi,Marie-Désirée Schlemper-Scheidt,Rocío Rivera Sánchez et al.
Siva Bandi et al.
N-acyl ethanolamines represent conserved lipophilic signaling molecules that function as endogenous ligands at G-protein-coupled receptors, ion channels, and nuclear receptors. Using a combination of comparative ultrahigh-performance liquid...
Leveraging the Capsular Polysaccharide Synthesis Pathway in Streptococcus pneumoniae as a Genetic Glycoengineering Platform [0.03%]
利用肺炎链球菌帽多糖合成途径作为基因型糖工程平台
Cheryl Kang-Rou Wong,Ye-Yu Chun,Tong Su et al.
Cheryl Kang-Rou Wong et al.
Engineering carbohydrates in living cells is one of the overarching goals of biology. In this Perspective, we discuss recent work in response to this challenge. Compared with eukaryotic cells, bacteria are fast-growing and genetically tract...
Radical Fluoromethylation Enabled by Cobalamin-Dependent Radical SAM Enzymes [0.03%]
依赖维生素B12的SAM radicals酶的激进型氟甲基化反应
Syam Sundar Neti,Bo Wang,Jiayuan Cui et al.
Syam Sundar Neti et al.
Fluorine is an important atom in many drugs because it can improve the efficacy and metabolic stability of many molecules. Strategies to incorporate monofluoromethyl groups in drugs have been limited and have received less attention than st...
Mechanism of Forced-Copy-Choice RNA Recombination by Enteroviral RNA-Dependent RNA Polymerases [0.03%]
肠道病毒RNA依赖性RNA聚合酶的强制复制选择型RNA重组机制研究
Jamie J Arnold,Alexandre Martinez,Abha Jain et al.
Jamie J Arnold et al.
Forced-copy-choice recombination occurs at the end of a template, differing from copy-choice recombination, which happens at internal positions. This mechanism may produce full-length genomes from fragments created by host antiviral respons...
PLAIG: Protein-Ligand Binding Affinity Prediction Using a Novel Interaction-Based Graph Neural Network Framework [0.03%]
基于新型相互作用图神经网络框架的蛋白质-配体结合亲和力预测模型
Madhav V Samudrala,Somanath Dandibhotla,Arjun Kaneriya et al.
Madhav V Samudrala et al.
Rapid prediction of protein-ligand binding affinity is important in the drug discovery process. The advent of machine learning methods has increased the speed of these predictions. Previous machine learning models based on structural, seque...
Alexander J Hughes,Julie A Talbert,Steven D Townsend
Alexander J Hughes
Substance use disorder (SUD) is a mental condition that affects a person's brain and behavior, leading to a lack of control with alcohol, drug, and medication use. The lack of efficacious and novel treatments for SUD is a growing concern. A...
Unraveling the GM1 Specificity of Galectin‑1 Binding to Lipid Membranes [0.03%]
galectin‑1与脂质膜结合的GM1特异性的研究解锁
Federica Scollo,Waldemar Kulig,Gabriele Nicita et al.
Federica Scollo et al.
Galectin-1 (Gal-1) is a galactose-binding protein involved in various cellular functions. Gal-1's activity has been suggested to be connected to two molecular concepts, which are, however, lacking experimental proof: a) enhanced binding aff...
Karim Almahayni,Jana Bachir Salvador,Dijo Moonnukandathil Jospeh et al.
Karim Almahayni et al.
The intersection of physics and medicine has long been a fertile ground for innovation, with advances in one field driving breakthroughs in the other. In recent years, the emergence of modern biophysical techniques has provided a toolbox fo...
Graphene Oxide in Bone Regenerative Engineering: Current Challenges and Future Perspectives [0.03%]
用于骨组织修复与再生的氧化石墨烯及其衍生物：现状、机遇与挑战
Fatemeh S Hosseini,Ho-Man Kan,Taraje Whitfield et al.
Fatemeh S Hosseini et al.
Owing to its exceptional physicochemical and biological properties, graphene oxide (GO), the oxidized form of graphene, has attracted considerable interest in bone regenerative engineering. The oxygen-functional groups on the backbone of GO...
RNA G‑Quadruplex Reprogramming with Guanine-Rich Antisense Oligonucleotides Inhibits Monoamine Oxidase B's Translation [0.03%]
富含鸟嘌呤的反义寡核苷酸介导的RNA G-四链体重构抑制单胺氧化酶B翻译
Marc-Antoine Turcotte,Jean-Pierre Perreault
Marc-Antoine Turcotte
The human transcriptome contains secondary RNA structures like RNA G-quadruplexes (rG4s) which regulate biological processes such as translation by ribosome stalling. Canonical rG4s, which are stabilized by both Hoogsteen hydrogen bonds and...