Mitochondria-Targeting Biquaternary Ammonium Compounds: Pancreatic Anticancer Activity and Synergistic Interaction with Metformin [0.03%]
线粒体靶向双季铵盐：抗胰腺癌活性及其与二甲双胍的协同作用
Maude Petit,Eugénie Daubas Prade,Andreea R Schmitzer
Maude Petit
Challenges in pancreatic cancer treatment primarily arise from chemotherapy resistance, cancer cell metastasis, and frequent late-stage diagnoses. These issues significantly compromise the effectiveness of standard treatments and highlight ...
5'-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously [0.03%]
当皮下给药时，具有内S-CDN的5'-硫磷酰胺环二核苷酸在体内表现出出色的抗肿瘤活性
Simpa K Yeboah,Sagarika Meher,Haley Anne Harper et al.
Simpa K Yeboah et al.
Cyclic dinucleotides (CDNs) have become popular as immunotherapies triggering an immune response achieved via their activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. Many analogs of 2'3'-cGAMP, c...
Thermodynamic Coupling between Folding Correctors and the First of Dimerized Nucleotide Binding Domains in CFTR [0.03%]
校正器与囊性纤维化跨膜转导调节因子二聚化核苷酸结合结构域之间的热力学耦合机制研究
Guangyu Wang
Guangyu Wang
The most common cystic fibrosis mutation is the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (hCFTR), which causes misfolding of the first of two nucleotide binding domains (NBD1/2), preventing Mg/ATP-de...
A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases [0.03%]
一个基于白细胞介素-18四肽序列的强效Caspase-8抑制剂揭示了炎性caspase和凋亡启动型caspase具有共同特异性
Christopher M Bourne,Nicole R Raniszewski,Ashutosh B Mahale et al.
Christopher M Bourne et al.
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes, such as programmed cell death and inflammation. Extensive efforts have been made to identify caspase substrat...
Mitigating Antimicrobial Resistance through Strategic Design of Multimodal Antibacterial Agents Based on 1,2,3-Triazole with Click Chemistry [0.03%]
基于点击化学的1,2,3-三唑多模式抗菌剂的设计合成及其抗耐药性研究
Shabin N Chathangad,Vishnu N Vijayan,Jissy Anna George et al.
Shabin N Chathangad et al.
Drug-resistant bacterial infections impose a major threat to human health, as current antibiotic treatments are becoming increasingly ineffective. Priority has been given to the development of alternative medications to curb the development...
Solomon K Attionu,Lukasz T Olenginski,Frances P Stump et al.
Solomon K Attionu et al.
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-specific isotopic labeling technologies ...
Application of Rational Design and Molecular Metadynamics for the Estimation of Changes in Trans-Splicing Efficiency during the Mutagenesis of Ssp DnaE Intein [0.03%]
有理设计和分子元动力学在Ssp DNAE intein诱变过程中反式剪接效率变化评估中的应用研究
Matvei O Sabantsev,Andrew N Brovin,Maxim A Gureev et al.
Matvei O Sabantsev et al.
Currently, inteins are some of the most popular multifunctional tools in the fields of molecular biology and biotechnology. In this study, we used the surface analysis method to identify the sites of intermolecular interactions between the ...
Squire J Booker,Tamra C Blue-Lahom
Squire J Booker
Brett Virgin-Downey,Luting Fang,Charles R Nosal et al.
Brett Virgin-Downey et al.
The 3-hydroxy-β-lactam (3-HβL) group derived from the natural product tabtoxinine-β-lactam (TβL), an inhibitor of glutamine synthetase, was repurposed to develop an inhibitor of dihydrofolate synthetase (DHFS). We show that replacement ...
A Click Chemistry-Based Biorthogonal Approach for the Detection and Identification of Protein Lysine Malonylation for Osteoarthritis Research [0.03%]
基于点击化学的生物正交方法在骨关节炎研究中用于蛋白质赖氨酸丙二酰化修饰的检测与鉴定
Anupama Binoy,Pandurangan Nanjan,Kavya Chellamuthu et al.
Anupama Binoy et al.
Lysine malonylation is a post-translational modification in which a malonyl group, characterized by a negatively charged carboxylate, is covalently attached to the ε-amino side chain of lysine, influencing protein structure and function. O...