Mitigating Antimicrobial Resistance through Strategic Design of Multimodal Antibacterial Agents Based on 1,2,3-Triazole with Click Chemistry [0.03%]
基于点击化学的1,2,3-三唑多模式抗菌剂的设计合成及其抗耐药性研究
Shabin N Chathangad,Vishnu N Vijayan,Jissy Anna George et al.
Shabin N Chathangad et al.
Drug-resistant bacterial infections impose a major threat to human health, as current antibiotic treatments are becoming increasingly ineffective. Priority has been given to the development of alternative medications to curb the development...
Solomon K Attionu,Lukasz T Olenginski,Frances P Stump et al.
Solomon K Attionu et al.
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-specific isotopic labeling technologies ...
Application of Rational Design and Molecular Metadynamics for the Estimation of Changes in Trans-Splicing Efficiency during the Mutagenesis of Ssp DnaE Intein [0.03%]
有理设计和分子元动力学在Ssp DNAE intein诱变过程中反式剪接效率变化评估中的应用研究
Matvei O Sabantsev,Andrew N Brovin,Maxim A Gureev et al.
Matvei O Sabantsev et al.
Currently, inteins are some of the most popular multifunctional tools in the fields of molecular biology and biotechnology. In this study, we used the surface analysis method to identify the sites of intermolecular interactions between the ...
Squire J Booker,Tamra C Blue-Lahom
Squire J Booker
Brett Virgin-Downey,Luting Fang,Charles R Nosal et al.
Brett Virgin-Downey et al.
The 3-hydroxy-β-lactam (3-HβL) group derived from the natural product tabtoxinine-β-lactam (TβL), an inhibitor of glutamine synthetase, was repurposed to develop an inhibitor of dihydrofolate synthetase (DHFS). We show that replacement ...
A Click Chemistry-Based Biorthogonal Approach for the Detection and Identification of Protein Lysine Malonylation for Osteoarthritis Research [0.03%]
基于点击化学的生物正交方法在骨关节炎研究中用于蛋白质赖氨酸丙二酰化修饰的检测与鉴定
Anupama Binoy,Pandurangan Nanjan,Kavya Chellamuthu et al.
Anupama Binoy et al.
Lysine malonylation is a post-translational modification in which a malonyl group, characterized by a negatively charged carboxylate, is covalently attached to the ε-amino side chain of lysine, influencing protein structure and function. O...
Glycosylated N‑Acyl Phosphoethanolamines as Bacterial Food-Dependent Signaling Molecules in Caenorhabditis Nematodes [0.03%]
细菌糖基化-N酰磷脂醇胺：作为秀丽隐杆线虫中的食物依赖型信号分子
Siva Bandi,Marie-Désirée Schlemper-Scheidt,Rocío Rivera Sánchez et al.
Siva Bandi et al.
N-acyl ethanolamines represent conserved lipophilic signaling molecules that function as endogenous ligands at G-protein-coupled receptors, ion channels, and nuclear receptors. Using a combination of comparative ultrahigh-performance liquid...
Leveraging the Capsular Polysaccharide Synthesis Pathway in Streptococcus pneumoniae as a Genetic Glycoengineering Platform [0.03%]
利用肺炎链球菌帽多糖合成途径作为基因型糖工程平台
Cheryl Kang-Rou Wong,Ye-Yu Chun,Tong Su et al.
Cheryl Kang-Rou Wong et al.
Engineering carbohydrates in living cells is one of the overarching goals of biology. In this Perspective, we discuss recent work in response to this challenge. Compared with eukaryotic cells, bacteria are fast-growing and genetically tract...
Radical Fluoromethylation Enabled by Cobalamin-Dependent Radical SAM Enzymes [0.03%]
依赖维生素B12的SAM radicals酶的激进型氟甲基化反应
Syam Sundar Neti,Bo Wang,Jiayuan Cui et al.
Syam Sundar Neti et al.
Fluorine is an important atom in many drugs because it can improve the efficacy and metabolic stability of many molecules. Strategies to incorporate monofluoromethyl groups in drugs have been limited and have received less attention than st...
Mechanism of Forced-Copy-Choice RNA Recombination by Enteroviral RNA-Dependent RNA Polymerases [0.03%]
肠道病毒RNA依赖性RNA聚合酶的强制复制选择型RNA重组机制研究
Jamie J Arnold,Alexandre Martinez,Abha Jain et al.
Jamie J Arnold et al.
Forced-copy-choice recombination occurs at the end of a template, differing from copy-choice recombination, which happens at internal positions. This mechanism may produce full-length genomes from fragments created by host antiviral respons...