Poly-Arginine Tails and Helical Segments of Natural Antimicrobial Peptides Display Concerted Action at Membranes for Enhanced Antimicrobial Effects [0.03%]
聚精氨酸尾部和天然抗菌肽中的螺旋片段在膜上协同作用以增强抗菌活性
Navleen Kaur,Kinjal Mondal,Megan E Mitchell et al.
Navleen Kaur et al.
Sequence motifs or patterns found in natural antimicrobial peptides (AMPs) have a great impact on their microbicidal activities. Here, through database inquiries and biological assays, we explore the enhanced antibacterial function associat...
Toward a Beautiful Amalgam: The Necessity of Heterogeneity in RNA Science and Research Culture [0.03%]
兼收并蓄：RNA科学研究文化异质性的必要性
Sudeshi M Abedeera,Mary Donnelly,James Hagerty et al.
Sudeshi M Abedeera et al.
RNA biology exemplifies functional heterogeneitydistinct RNA classes are expressed in tissue- and development-specific contexts, adopt dynamic conformational ensembles, and form intricate, context-dependent interactions with proteins and ...
Morpholinoethoxy-Substituted Cationic Metal-Free and Metallo Phthalocyanines: In Vitro Photodynamic Therapy Activities, PDT-Induced ROS Level Measurements, and Cellular Death Mechanism [0.03%]
N-甲氧基乙基化形态金属自由和金属洛通：体内光动力治疗活性，PDT引起的ROS水平测量和细胞死亡机制
Muge Serhatli,Seyma Isik,Ayfer Kalkan et al.
Muge Serhatli et al.
In this study, morpholinoethoxy-attached cationic tetra-substituted phthalocyanines (Pcs), including metal-free (HQH 2 Pc), zinc (HQZnPc), and indium (HQInPc) derivatives, were synthesized following established protocols. Their structures w...
Bridging Health Disparity Gaps in Alzheimer's Disease among Marginalized Populations: Clinical Proteomics as a Case Study [0.03%]
临床蛋白质组学为例探究阿尔茨海默病患者中的边缘群体的健康差距问题
Henry A Adeola,Renã A S Robinson
Henry A Adeola
Alzheimer's disease (AD) and AD-related dementias (ADRD) represent a significant health challenge, with a growing impact on marginalized populations who often experience inequities in overall healthcare access and outcomes. Many factors con...
Introducing the Tutorial Manuscript Type at the ACS Au Community Journals [0.03%]
美国化学学会Au社区期刊教程手稿类型的介绍
Squire J Booker,Stephanie L Brock,Xiangdong Li et al.
Squire J Booker et al.
In Vitro and In Vivo Antifungal Efficacy and Safety of the Ca Def2.1G27‑K44 Peptide against the Neglected and Drug-Resistant Pathogen [0.03%]
Ca Def2.1G27-K44肽对被忽视和耐药真菌的体内外抗真菌活性及安全性评估
Thomas Z A Guimarães,Érica O Mello,Douglas R Lucas et al.
Thomas Z A Guimarães et al.
The growing threat of fungal infections, driven by increasing drug resistance, has become a major global health concern. Candidiasis, a common human infection, is associated with high mortality, particularly in invasive cases. Among non- (N...
Mitochondria-Targeting Biquaternary Ammonium Compounds: Pancreatic Anticancer Activity and Synergistic Interaction with Metformin [0.03%]
线粒体靶向双季铵盐：抗胰腺癌活性及其与二甲双胍的协同作用
Maude Petit,Eugénie Daubas Prade,Andreea R Schmitzer
Maude Petit
Challenges in pancreatic cancer treatment primarily arise from chemotherapy resistance, cancer cell metastasis, and frequent late-stage diagnoses. These issues significantly compromise the effectiveness of standard treatments and highlight ...
5'-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously [0.03%]
当皮下给药时，具有内S-CDN的5'-硫磷酰胺环二核苷酸在体内表现出出色的抗肿瘤活性
Simpa K Yeboah,Sagarika Meher,Haley Anne Harper et al.
Simpa K Yeboah et al.
Cyclic dinucleotides (CDNs) have become popular as immunotherapies triggering an immune response achieved via their activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. Many analogs of 2'3'-cGAMP, c...
Thermodynamic Coupling between Folding Correctors and the First of Dimerized Nucleotide Binding Domains in CFTR [0.03%]
校正器与囊性纤维化跨膜转导调节因子二聚化核苷酸结合结构域之间的热力学耦合机制研究
Guangyu Wang
Guangyu Wang
The most common cystic fibrosis mutation is the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (hCFTR), which causes misfolding of the first of two nucleotide binding domains (NBD1/2), preventing Mg/ATP-de...
A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases [0.03%]
一个基于白细胞介素-18四肽序列的强效Caspase-8抑制剂揭示了炎性caspase和凋亡启动型caspase具有共同特异性
Christopher M Bourne,Nicole R Raniszewski,Ashutosh B Mahale et al.
Christopher M Bourne et al.
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes, such as programmed cell death and inflammation. Extensive efforts have been made to identify caspase substrat...