Synthesis of a Water-Soluble BODIPY for Targeting and Assessing the Function of Endoplasmic Reticulum [0.03%]
用于内质网靶向及功能评估的水溶性BODIPY染料的合成
Jacopo Tricomi,Giacomo Biagiotti,Tommy Chastel et al.
Jacopo Tricomi et al.
We report here on a straightforward methodology to synthesize a new water-soluble fluorescent probe Tris-BODIPY-OH 1 that contains three pH-independent hydrophilic arms. This probe has been prepared by exploiting a synthetic strategy that i...
Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook [0.03%]
靶向蛋白质降解在农业应用中的作用：原理、挑战与前景
Denis Fourches,Joseph Pilotte,Brian E Watts et al.
Denis Fourches et al.
Farmers urgently need novel technologies to ensure global food security for the rapidly expanding population, yet crop protection has seen little innovation in decades. Mounting regulatory pressures, pest resistance, and environmental conce...
Transition State Analysis of the Aldol-Like Reaction Catalyzed by NeuB, a Sialic Acid Synthase, Reveals a Stepwise Cationic Mechanism [0.03%]
神经氨酸合成酶NeuB催化的类似aldol反应的过渡态分析揭示了逐步阳离子机制
Pallavi Mukherjee,Chen Niu,Paul J Berti
Pallavi Mukherjee
The sialic acid synthase NeuB, and other α-carboxyketose synthases, are long-standing targets for inhibition by potential antimicrobial compounds. NeuB catalyzes an aldol-like reaction of phosphoenolpyruvate (PEP) and N-acetylmannosamine (...
Allosteric Modulation of Cannabinoid Type 1 Receptor by ZCZ011: Integration of In Vitro Pharmacology and Molecular Dynamics Simulation [0.03%]
allosteric调节剂ZCZ011对大麻素受体1的药理学及分子动力学研究
Tara Chand Yadav,Lakshmipriya Indira Swaminathan,Venkat R Chirasani et al.
Tara Chand Yadav et al.
Over the years, the cannabinoid type 1 receptor (CB1R) has emerged as a promising therapeutic target for addressing various neurodegenerative diseases including HIV-associated neurocognitive disorders (HAND). However, the therapeutic applic...
Selenium Exerts Antimicrobial Activity against the Perinatal Pathogen Streptococcus agalactiae and Perturbs Bacterial Interactions with Human Gestational Membranes [0.03%]
硒对围产期病原菌无乳链球菌具有抗菌作用并干扰细菌与人胎膜的相互作用
Riya Chinni,Kensley Horner,Walter Avila et al.
Riya Chinni et al.
Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a Gram-positive, encapsulated, pathogenic bacterium. GBS causes severe perinatal infections that lead to chorioamnionitis, funisitis, premature rupture of membranes, pret...
Local and Global Breathing Motions Prime the Access to Buried Binding Site in an Antibiotic-Sequestering Protein [0.03%]
局部和全局呼吸运动促进了抗生素结合蛋白中埋藏的配体结合位点的形成
Lawanya Natarajan,Dmitry Loginov,Alan Kadek et al.
Lawanya Natarajan et al.
Proteins frequently undergo large-scale conformational excursions in their native ensemble. Such structural transitions are particularly critical for enabling access to binding sites when they are buried in the protein interior. Here, we ma...
Correction " ACS Bio & Med Chem Au: Introducing the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry" [0.03%]
“ACS 生物与药物化学金：介绍 2024 年生物、医药和药学化学新星”
Squire J Booker
Squire J Booker
[This corrects the article DOI: 10.1021/acsbiomedchemau.5c00080.]. © 2025 American Chemical Society.
Published Erratum
ACS bio & med chem Au. 2025 Aug 25;5(5):920. DOI:10.1021/acsbiomedchemau.5c00147 2025
Ciprofloxacin Inhibits Angiotensin I‑Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket [0.03%]
环丙沙星通过与催化袋远处的表位结合抑制血管紧张素转化酶(ACE)活性
Kyle S Gregory,Vinasha Ramasamy,Edward D Sturrock et al.
Kyle S Gregory et al.
Human somatic angiotensin I-converting enzyme is a key zinc metallopeptidase in cardiovascular regulation that hydrolyzes angiotensin peptides (Ang I, Ang II), as well as other vasoactive peptides, including kinins (e.g., bradykinin), subst...
Machine Learning-Guided Design of Rhenium Tricarbonyl Complexes for Next-Generation Antibiotics [0.03%]
机器学习引导设计下一代抗生素的三羰基核苷酸配合物
Miroslava Nedyalkova,Gozde Demirci,Youri Cortat et al.
Miroslava Nedyalkova et al.
The escalating prevalence of antibiotic-resistant bacteria and the increasing complexity of managing severe infections emphasize the critical need for novel and effective antibiotics. Herein, we present a novel computational strategy focuse...
Bridging Viral Glycobiology and Lectin Biotechnology for Antiviral and Diagnostic Strategies [0.03%]
糖生物学和凝集素生物技术在抗病毒及诊断策略中的应用桥梁
Benildo Sousa Cavada,Vinicius Jose Silva Osterne,Messias Vital Oliveira et al.
Benildo Sousa Cavada et al.
Lectins, proteins that reversibly bind specific glycan motifs, offer dual utility as molecular probes or inhibitors of virus-host interactions. This review explores the molecular interactions between lectins and viral envelope glycoproteins...