Blue Fluorescent Siloxytecans Exhibit Potent Anticancer Activity and Enable Direct Real-Time Quantification of Intracellular Uptake [0.03%]
蓝色荧光硅氧杂茋化合物具有强大的抗肿瘤活性并能够直接实现实时量化细胞内摄取
Isabella Lo,Sanika Vaidya,Ashley Mo et al.
Isabella Lo et al.
Notwithstanding the natural abundance of silicon on Earth, silicon-containing compounds comprise relatively few pharmaceutical drugs, though several silylated natural products have demonstrated greater bioavailability and lipophilicity. Her...
Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification [0.03%]
甲醛作为活化剂和构建模块在固相肽修饰中发挥的益生作用
Jamie C Thuan,Anuja Koirala,James Pirez et al.
Jamie C Thuan et al.
Signal transduction by gaseous small molecules is an essential process in modern living systems, where the gasotransmitters relay cellular signals to bio-(macro)-molecules through covalent bond formation. However, the origin or a primordial...
A Tutorial Review on Surface Plasmon Resonance Biosensors: Applications in Biomedicine [0.03%]
基于表面等离子体共振生物传感器的生物医学应用进展及评述
Antony Chirco,Elisabetta Meacci,Giancarlo Margheri
Antony Chirco
Surface Plasmon Resonance (SPR) has proven to be one of the most effective technologies in terms of specificity, affinity, and determination of kinetic parameters for evaluating interactions between macromolecules. The focus of this tutoria...
Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G‑Quadruplexes and Their Protein Binding Partners [0.03%]
光活化生物模拟配体photoMultiTASQ捕获DNA/RNA G-四链体及其蛋白质结合伴侣
Sandy Raevens,Yehuda M Danino,Cécile Desingle et al.
Sandy Raevens et al.
The biological role of DNA and RNA G-quadruplexes (G4s) is relayed to the cellular circuitry by a plethora of proteins known as G4-binding proteins (G4PBs). It is thus critical to decipher the formation of the G4/G4BP complexes to accuratel...
1,2,4-Triazole-Based First-in-Class Non-Nucleoside Inhibitors of the Bacterial Enzyme MraY [0.03%]
一类新的非核苷类细菌MraY酶抑制剂——基于1,2,4-三唑的首创新药抑制剂
Tomayo Berida,Tzu-Yu Huang,Stefanie C Weck et al.
Tomayo Berida et al.
MraY is an essential bacterial enzyme for peptidoglycan synthesis in cell walls and serves as a promising but unrealized target for developing effective antibacterial drugs. Nature has provided a remarkable array of nucleoside inhibitors of...
Functional D- and L‑Naphthalenediimide-Peptides: Microwave-Driven Synthesis, Supramolecular Aggregation, and Multiphoton Fluorescence Lifetime Imaging Microscopy in Living Cells [0.03%]
功能性的D-和L-萘二酰亚胺肽：微波驱动合成、超分子聚集以及活细胞中的多光子荧光寿命成像 microscopy
Simone G Giuffrida,David G Calatayud,Fernando Cortezon-Tamarit et al.
Simone G Giuffrida et al.
We report the microwave-assisted synthesis of a novel family of peptide-linked optical imaging probes incorporating the L-[7,13] bombesin fragment (denoted L-[7,13]-BBN) as a functional building block currently used for targeting the gastri...
Leader-Independent C‑Terminal Modification by a Radical S‑Adenosyl‑l‑methionine Maturase Enables Macrocyclic GLP-1-Like Peptides [0.03%]
不含领导肽的环化GLP-1类似物前体肽的自由基SAM成熟酶介导的末端修饰
Jacob K Pedigo,Karsten A S Eastman,Vahe Bandarian
Jacob K Pedigo
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a rapidly expanding family of natural products in which biosynthetic maturase enzymes tailor ribosomal precursors into bioactive products. Classical RiPP maturat...
Manipulation of 7‑Finger Zinc Finger Nuclease Increases the Efficiency of Genome Editing in Human Cells [0.03%]
利用7指锌指核酸酶提高人类细胞的基因组编辑效率
Shota Katayama,Masahiro Watanabe,Wataru Nomura et al.
Shota Katayama et al.
Genome editing tools have great potential for medicinal use. Among them, zinc finger nucleases (ZFNs) are smaller in size than transcriptional activator-like effector nucleases and CRISPR-Cas9. Therefore, ZFNs are easily packed into a viral...
High-Throughput Microfluidic Technologies for Rapidly Screening Pollutant-Induced Cell Health Effects [0.03%]
高通量微流控技术快速筛查污染物引起的细胞健康效应
Blanca I Quiñones-Díaz,Niphattha Wongwiset,Pratik Kamat et al.
Blanca I Quiñones-Díaz et al.
Air pollution exposure is linked to diseases spanning multiple physiological systems. However, environmental stress is overwhelmingly associated with several lung diseases. Since the chemical composition of air pollutants varies widely acro...
Malkeet Kumar,Anees Ahmad,Anna Caroline Campos Aguiar et al.
Malkeet Kumar et al.
Malaria still stands out as one of the most devastating and prevalent diseases globally, where the rise of resistance to different antimalarial drugs in different regions has posed significant obstacles to global treatment and elimination. ...