Selenium Exerts Antimicrobial Activity against the Perinatal Pathogen Streptococcus agalactiae and Perturbs Bacterial Interactions with Human Gestational Membranes [0.03%]
硒对围产期病原菌无乳链球菌具有抗菌作用并干扰细菌与人胎膜的相互作用
Riya Chinni,Kensley Horner,Walter Avila et al.
Riya Chinni et al.
Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a Gram-positive, encapsulated, pathogenic bacterium. GBS causes severe perinatal infections that lead to chorioamnionitis, funisitis, premature rupture of membranes, pret...
Local and Global Breathing Motions Prime the Access to Buried Binding Site in an Antibiotic-Sequestering Protein [0.03%]
局部和全局呼吸运动促进了抗生素结合蛋白中埋藏的配体结合位点的形成
Lawanya Natarajan,Dmitry Loginov,Alan Kadek et al.
Lawanya Natarajan et al.
Proteins frequently undergo large-scale conformational excursions in their native ensemble. Such structural transitions are particularly critical for enabling access to binding sites when they are buried in the protein interior. Here, we ma...
Correction " ACS Bio & Med Chem Au: Introducing the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry" [0.03%]
“ACS 生物与药物化学金：介绍 2024 年生物、医药和药学化学新星”
Squire J Booker
Squire J Booker
[This corrects the article DOI: 10.1021/acsbiomedchemau.5c00080.]. © 2025 American Chemical Society.
Published Erratum
ACS bio & med chem Au. 2025 Aug 25;5(5):920. DOI:10.1021/acsbiomedchemau.5c00147 2025
Ciprofloxacin Inhibits Angiotensin I‑Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket [0.03%]
环丙沙星通过与催化袋远处的表位结合抑制血管紧张素转化酶(ACE)活性
Kyle S Gregory,Vinasha Ramasamy,Edward D Sturrock et al.
Kyle S Gregory et al.
Human somatic angiotensin I-converting enzyme is a key zinc metallopeptidase in cardiovascular regulation that hydrolyzes angiotensin peptides (Ang I, Ang II), as well as other vasoactive peptides, including kinins (e.g., bradykinin), subst...
Machine Learning-Guided Design of Rhenium Tricarbonyl Complexes for Next-Generation Antibiotics [0.03%]
机器学习引导设计下一代抗生素的三羰基核苷酸配合物
Miroslava Nedyalkova,Gozde Demirci,Youri Cortat et al.
Miroslava Nedyalkova et al.
The escalating prevalence of antibiotic-resistant bacteria and the increasing complexity of managing severe infections emphasize the critical need for novel and effective antibiotics. Herein, we present a novel computational strategy focuse...
Bridging Viral Glycobiology and Lectin Biotechnology for Antiviral and Diagnostic Strategies [0.03%]
糖生物学和凝集素生物技术在抗病毒及诊断策略中的应用桥梁
Benildo Sousa Cavada,Vinicius Jose Silva Osterne,Messias Vital Oliveira et al.
Benildo Sousa Cavada et al.
Lectins, proteins that reversibly bind specific glycan motifs, offer dual utility as molecular probes or inhibitors of virus-host interactions. This review explores the molecular interactions between lectins and viral envelope glycoproteins...
Kinetic Characterization of F 420-Dependent Sugar-6-Phosphate Dehydrogenase from Cryptosporangium arvum [0.03%]
来源于Cryptosporangium arvum的F420依赖型糖磷酸脱氢酶的动力学性质研究
Alaa Aziz,Desiree R Czapski,Ravi Ramkissoon et al.
Alaa Aziz et al.
F 420-dependent glucose-6-phosphate dehydrogenase (FGD) catalyzes the oxidation of glucose-6-phosphate (G6P) to 6-phosphogluconolactone (6PG). Recent phylogenetic analyses have identified a new subclass of these enzymes, F 420-dependent sug...
Annalisa Invernizzi,Francesco Nai,Rajiv Kumar Bedi et al.
Annalisa Invernizzi et al.
N 6-Adenosine methylation is the most abundant modification of mRNA. The three members of the YTH domain family proteins (YTHDF1-3) recognize in the cytoplasm the m6A-RNA modification. We screened a library of about 500,000 fragments (i.e.,...
Overcoming Global Antifungal Challenges: Medical and Agricultural Aspects [0.03%]
全球抗真菌挑战：医学和农业方面面临的难题及应对策略
László Galgóczy
László Galgóczy
The prevalence of fungal infections and contamination has increased alarmingly over the past decade, posing a significant threat to human health and the food supply and negatively affecting welfare. This escalating concern is primarily attr...
Phenylalkyl Acetophenones and Anacardic Acids from Knema oblongifolia with Synthetic Analogues as Anti-infectives and Antibacterial Agents [0.03%]
来源于拟卫矛长果种的苯基丙酮和山胡椒酸及其抗感染和抗菌活性类似物的研究
Olivier Auguste Kirchhoffer,Jahn Nitschke,Alexandre Luscher et al.
Olivier Auguste Kirchhoffer et al.
The present study investigates the potential anti-infective and antibacterial properties of phenylalkyl acetophenones and anacardic acids isolated from the ethyl acetate extract of the leaves of Knema oblongifolia, along with synthetic deri...