Mutually Exclusive Interactions of Rifabutin with Spatially Distinct Mycobacterial Cell Envelope Membrane Layers Offer Insights into Membrane-Centric Therapy of Infectious Diseases [0.03%]
利福布汀与空间上不同的麻风分枝杆菌细胞包膜不同膜层相互作用的互斥性为抗菌膜靶点理论提供了新思路
Anjana P Menon,Wanqian Dong,Tzong-Hsien Lee et al.
Anjana P Menon et al.
The mycobacterial cell envelope has spatially resolved inner and outer membrane layers with distinct compositions and membrane properties. However, the functional implication and relevance of this organization remain unknown. Using membrane...
Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules [0.03%]
克霉唑偶联一氧化碳释放剂的协同抗菌活性及作用机制研究
Sofia S Mendes,Joana Marques,Edit Mesterházy et al.
Sofia S Mendes et al.
Several metal-based carbon monoxide-releasing molecules (CORMs) are active CO donors with established antibacterial activity. Among them, CORM conjugates with azole antibiotics of type [Mn(CO)3(2,2'-bipyridyl)(azole)]+ display important syn...
Identification of Natural Product Sulfuretin Derivatives as Inhibitors for the Endoplasmic Reticulum Redox Protein ERO1α [0.03%]
鉴定天然产物硫黄素衍生物作为内质网氧化还原蛋白ERO1α的抑制剂
Brennan D Johnson,Sridhar Kaulagari,Wei-Chih Chen et al.
Brennan D Johnson et al.
The flavin adenine dinucleotide containing Endoplasmic Reticulum Oxidoreductase-1 α (ERO1α) catalyzes the formation of de novo disulfide bond formation of secretory and transmembrane proteins and contributes towards proper protein folding...
Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance [0.03%]
新型选择性雌激素受体α激动剂JND003可改善非酒精性脂肪肝和胰岛素抵抗
Liufeng Mao,Lijie Peng,Xiaomei Ren et al.
Liufeng Mao et al.
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver diseases and is causally linked to hepatic insulin resistance and reduced fatty acid oxidation. Therapeutic treatments targeting both hepatic insul...
Sambashiva Banala,Ariana N Tkachuk,Ronak Patel et al.
Sambashiva Banala et al.
Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This ...
Vahe Bandarian
Vahe Bandarian
Radical S-adenosyl-l-methionine (SAM) enzymes catalyze a diverse group of complex transformations in all aspects of cellular physiology. These metalloenzymes bind SAM to a 4Fe-4S cluster and reductively cleave SAM to generate a 5'-deoxyaden...
Cobalamin-Dependent Radical S-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions [0.03%]
钴胺素依赖性游离基S-腺苷甲硫氨酸酶：利用旧有模式产生新的功能
Jennifer Bridwell-Rabb,Bin Li,Catherine L Drennan
Jennifer Bridwell-Rabb
The members of the radical S-adenosylmethionine (SAM) enzyme superfamily are responsible for catalyzing a diverse set of reactions in a multitude of biosynthetic pathways. Many members of this superfamily accomplish their transformations us...
Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity [0.03%]
一种外泌体封装核酸支架化疗药物用于增强抗肿瘤和抑制血管生成作用
Ryan P McNamara,Anthony B Eason,Yijun Zhou et al.
Ryan P McNamara et al.
Extracellular vesicles (EVs), or exosomes, play a pivotal role in tumor growth and metastasis, such as in the case of Kaposi Sarcoma. By loading tumor-derived EVs with chemotherapeutic drugs, we noted that their pro-tumor/pro-angiogenic phe...
Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems [0.03%]
揭秘莫亚A类Radical SAM酶数十年之谜发现解决人类健康问题的新机遇
Kenichi Yokoyama,Di Li,Haoran Pang
Kenichi Yokoyama
MoaA is one of the most conserved radical S-adenosyl-l-methionine (SAM) enzymes, and is found in most organisms in all three kingdoms of life. MoaA contributes to the biosynthesis of molybdenum cofactor (Moco), a redox enzyme cofactor used ...
Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes [0.03%]
钴胺素依赖的Radical SAM酶研究方法的发展变迁
Erica K Sinner,Daniel R Marous,Craig A Townsend
Erica K Sinner
While bioinformatic evidence of cobalamin-dependent radical S-adenosylmethionine (SAM) enzymes has existed since the naming of the radical SAM superfamily in 2001, none were biochemically characterized until 2011. In the past decade, the fi...