Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology [0.03%]
铁蛋白：极具潜力的纳米反应器和生物纳米技术载体
Abhinav Mohanty,Akankshika Parida,Rohit Kumar Raut et al.
Abhinav Mohanty et al.
The essence of bionanotechnology lies in the application of nanotechnology/nanomaterials to solve the biological problems. Quantum dots and nanoparticles hold potential biomedical applications, but their inherent problems such as low solubi...
Molecular Aspects of Insulin Aggregation and Various Therapeutic Interventions [0.03%]
胰岛素聚集的分子机制及各种治疗干预措施
Anirban Das,Mosami Shah,Ishu Saraogi
Anirban Das
Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on human health ranging from fatigue and numbness to organ failure and death in extreme cases. Insulin, a peptide hormone commonly used to treat dia...
Importance of Extracellular Vesicle Derived RNAs as Critical Colorectal Cancer Biomarkers [0.03%]
外泌体衍生RNA作为关键结直肠癌生物标志物的重要性
Brateen Datta,Debashish Paul,Tina Dey et al.
Brateen Datta et al.
Colorectal cancer typically begins from a nonmalignant polyp formation in the large intestine that, over time, develops into colorectal cancer. The growth of benign polyps can be checked if detected in the early stages of the disease. Docto...
Yunfei Zuo,Hanchen Shen,Feiyi Sun et al.
Yunfei Zuo et al.
Cell death is closely related to various diseases, and monitoring and controlling cell death is a promising strategy to develop efficient therapy. Aggregation-induced emission luminogens (AIEgens) are ideal candidates for developing novel t...
Continuous Flow Synthesis of A2E Guided by Design of Experiments and High-Throughput Studies [0.03%]
基于试验设计和高通量研究的A2E连续流动合成法
Giulia Murbach-Oliveira,Kalpita Banerjee,Marcelo M Nociari et al.
Giulia Murbach-Oliveira et al.
N-Retinylidene-N-retinylethanolamine (A2E) is the most studied lipid bisretinoid. It forms lipofuscin deposits in the retinal pigment epithelium (RPE), causing vision impairment and blindness in eye conditions, such as Stargardt's disease, ...
Practical Synthesis of Antimicrobial Long Linear Polyamine Succinamides [0.03%]
抗菌长链聚胺琥珀酰亚胺的合成方法及其应用
Abdulaziz H Alkhzem,Shuxian Li,Toska Wonfor et al.
Abdulaziz H Alkhzem et al.
There are many severe bacterial infections notorious for their ability to become resistant to clinically relevant antibiotics. Indeed, antibiotic resistance is a growing threat to human health, further exacerbated by the lack of new antibio...
KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement [0.03%]
一种同时抑制鸟苷三磷酸交换活性和效应物结合的KARS抑制剂
Cynthia V Pagba,Amit K Gupta,Ali K Naji et al.
Cynthia V Pagba et al.
We describe a small molecule ligand ACA-14 (2-hydroxy-5-{[(2-phenylcyclopropyl) carbonyl] amino} benzoic acid) as an initial lead for the development of direct inhibitors of KRAS, a notoriously difficult anticancer drug target. We show that...
Squire J Booker,Cody T Lloyd
Squire J Booker
Pedro Salas-Ambrosio,Shelby Vexler,Rajalakshmi P S et al.
Pedro Salas-Ambrosio et al.
One of the primary global health concerns is the increase in antimicrobial resistance. Polymer chemistry enables the preparation of macromolecules with hydrophobic and cationic side chains that kill bacteria by destabilizing their membranes...
Synthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors [0.03%]
甲基莲碱类似物的合成及其对人α7烟碱型乙酰胆碱受体的拮抗活性研究
Ashraf M A Qasem,Michael G Rowan,Victoria R Sanders et al.
Ashraf M A Qasem et al.
Methyllycaconitine (MLA), 1, is a naturally occurring norditerpenoid alkaloid that is a highly potent (IC50 = 2 nM) selective antagonist of α7 nicotinic acetylcholine receptors (nAChRs). Several structural factors affect its activity such ...