Jinduo Cheng,Wan-Qiu Liu,Xiaoyu Zhu et al.
Jinduo Cheng et al.
HemN is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the anaerobic oxidative decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, a key intermediate in heme biosynthesis. Proteins homologous to HemN (Hem...
Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation [0.03%]
参与厌氧血红素降解的SAM结合甲基转移酶C亚家族成员
Liju G Mathew,Marley Brimberry,William N Lanzilotta
Liju G Mathew
Class C radical SAM methyltransferases catalyze a diverse array of difficult chemical transformations in the biosynthesis of a range of compounds of biomedical importance. Phylogenetic analysis suggests that all of these enzymes are related...
Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity [0.03%]
具有输送反义吗啉寡聚物活性的穿膜d-肽保留了其生物活性
Carly K Schissel,Charlotte E Farquhar,Annika B Malmberg et al.
Carly K Schissel et al.
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant macromolecules such as proteins and oligonucleotides. For example, recent clinical trials have shown that a CPP attached to...
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery [0.03%]
靶向蛋白降解在传染病研究中的应用：从基础生物学研究到药物发现
Rocío Marisol Espinoza-Chávez,Alessandra Salerno,Anastasia Liuzzi et al.
Rocío Marisol Espinoza-Chávez et al.
Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated protein degradation may offer several benefits over classic...
Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides [0.03%]
核糖体合成和翻译后修饰肽的发现、生物工程及活性评价最新研究进展
Guannan Zhong,Zong-Jie Wang,Fu Yan et al.
Guannan Zhong et al.
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are of increasing interest in natural products as well as drug discovery. This empowers not only the unique chemical structures and topologies in natural products bu...
A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells [0.03%]
一种基于荧光的检测GLUT5抑制剂的方法及应用研究_fructose mimics对乳腺癌细胞GLUT5转运的影响
Natasha Rana,Marwa A Aziz,Rabah A T Serya et al.
Natasha Rana et al.
Rapid cell division and reprogramming of energy metabolism are two crucial hallmarks of cancer cells. In humans, hexose trafficking into cancer cells is mainly mediated through a family of glucose transporters (GLUTs), which are facilitativ...
Modeling the Effect of Cooperativity in Ternary Complex Formation and Targeted Protein Degradation Mediated by Heterobifunctional Degraders [0.03%]
合作效应在三元复合物形成和异双功能降解剂介导的目标蛋白质降解中的作用建模
Daniel Park,Jesus Izaguirre,Rory Coffey et al.
Daniel Park et al.
Chemically induced proximity between certain endogenous enzymes and a protein of interest (POI) inside cells may cause post-translational modifications to the POI with biological consequences and potential therapeutic effects. Heterobifunct...
TLR4 Blockade Using Docosahexaenoic Acid Restores Vulnerability of Drug-Tolerant Tumor Cells and Prevents Breast Cancer Metastasis and Postsurgical Relapse [0.03%]
使用二十二碳六烯酸阻断 toll 样受体 4 可恢复药物耐受性肿瘤细胞的脆弱性并预防乳腺癌转移和术后复发
Mou Wang,Yuejing Wang,Renhe Liu et al.
Mou Wang et al.
Nonmutational mechanisms were recently discovered leading to reversible drug tolerance. Despite the rapid elimination of a majority of tumor cells, a small subpopulation of "'drug-tolerant"' cells remain viable with lethal drug exposure, wh...
Radical SAM Enzymes Involved in Tetrapyrrole Biosynthesis and Insertion [0.03%]
参与四吡咯生物合成和插入的 Radical SAM 酶
Gunhild Layer,Martina Jahn,Jürgen Moser et al.
Gunhild Layer et al.
The anaerobic biosyntheses of heme, heme d 1, and bacteriochlorophyll all require the action of radical SAM enzymes. During heme biosynthesis in some bacteria, coproporphyrinogen III dehydrogenase (CgdH) catalyzes the decarboxylation of two...
No Limits: Using Art to Inspire and Encourage Minorities to Pursue Careers in STEAM (STEM + Art) [0.03%]
没有极限：用艺术激励和鼓励少数族裔从事STE(A)M职业
Jayde Frederick
Jayde Frederick