Elucidating the Eradication Mechanism of Perillyl Alcohol against Candida glabrata Biofilms: Insights into the Synergistic Effect with Azole Drugs [0.03%]
阐明_PERillyl_醇清除_Candida_glabrata_生物被膜机制：与唑类药物协同增效作用的启示
Payal Gupta,Krishna Mohan Poluri
Payal Gupta
Increased incidences of fungal infections and associated mortality have accelerated the need for effective and alternative therapeutics. Perillyl alcohol (PA) is a terpene produced by the hydroxylation of limonene via the mevalonate pathway...
Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View [0.03%]
从结构角度浅谈RADICAL SAM酶及金属辅因子簇的组装
Yvain Nicolet,Mickael V Cherrier,Patricia Amara
Yvain Nicolet
This Review focuses on the structure-function relationship of radical S-adenosyl-l-methionine (SAM) enzymes involved in the assembly of metallocofactors corresponding to the active sites of [FeFe]-hydrogenase and nitrogenase [MoFe]-protein....
A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery [0.03%]
作为药物发现中颇有前景的先导化合物的甾体生物缀合物综述
Ranju Bansal,Amruta Suryan
Ranju Bansal
Ever increasing unmet medical requirements of the human race and the continuous fight for survival against variety of diseases give birth to novel molecules through research. As diseases evolve, different strategies are employed to counter ...
Shedding Light on the Elephant in a Dark Room in the Discovery of New Medicine: Highlighting Molecular Pharmaceutics within ACS Bio & Med Chem Au [0.03%]
拨开黑暗房间里的大象——论ACS Bio & Med Chem Au上药物发现中分子药剂学的重要性
Afsaneh Lavasanifar,Lynne S Taylor
Afsaneh Lavasanifar
Efficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease [0.03%]
高效设计蛋白酶抑制剂的策略：手足口病毒71型2A蛋白酶应用示例
Ting Chen,Cédric Grauffel,Wei-Zen Yang et al.
Ting Chen et al.
One strategy to counter viruses that persistently cause outbreaks is to design molecules that can specifically inhibit an essential multifunctional viral protease. Herein, we present such a strategy using well-established methods to first i...
Katarzyna Ożga,Łukasz Berlicki
Katarzyna Ożga
The potential of miniproteins in the biological and chemical sciences is constantly increasing. Significant progress in the design methodologies has been achieved over the last 30 years. Early approaches based on propensities of individual ...
Discovery of a New Chemoeffector for Escherichia coli Chemoreceptor Tsr and Identification of a Molecular Mechanism of Repellent Sensing [0.03%]
结肠炎志贺菌鞭毛蛋白介导的宿主细胞毒力作用及其诱导的肠道炎症反应研究
Xi Chen,Shuangyu Bi,Xiaomin Ma et al.
Xi Chen et al.
Motile bacteria use chemotaxis to search for nutrients and escape from harmful chemicals. While the sensing mechanisms for chemical attractants are well established, the molecular details of chemorepellent detection are poorly understood. H...
Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist [0.03%]
高选择性 neuromedin U 体2激动剂的意外特性研究
Suneet Mehrotra,Sebastian Lam,Elizabeth Glenn et al.
Suneet Mehrotra et al.
Neuromedin-U (NMU) mediates several physiological functions via its two cognate receptors, NMUR1 and NMUR2. Disentangling the individual roles of each receptor has largely been undertaken through the use of transgenic mice bearing a deletio...
Iso-α-acids in Nonalcoholic and Alcoholic Beer Stimulate Growth of Neuron-like SH-SY5Y Cells and Neuroepithelial Stem Cells [0.03%]
异α酸对神经样SH-SY5Y细胞和神经上皮干细胞的增殖作用研究：无醇啤酒和酒精啤酒中的异α酸的区别研究
Agneta J Laurent,Niels Bindslev,Vladana Vukojević et al.
Agneta J Laurent et al.
With the increasing popularity of nonalcoholic beer, the association between beer drinking and alcohol intake is lost. In the present study, we show that nonalcoholic beer can stimulate the expansion of neuron-like cell lines and neuroepith...
Funding Mandates and the Launch of Nine Fully Open Access ACS Au Journals [0.03%]
资助要求与九种完全开放获取的ACS Au期刊的发布
Shelley Minteer
Shelley Minteer