Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling [0.03%]
扎非卢克斯特可作为选择性抑制TNFR1信号的有前途的支架
Nagamani Vunnam,Mu Yang,Chih Hung Lo et al.
Nagamani Vunnam et al.
Tumor necrosis factor (TNF) plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease. The biological effects of TNF are mediated by binding to TNF receptors, TNF re...
Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage [0.03%]
PACIFIC：通过反复切割实现光活化免疫荧光多重蛋白成像
Fei Ji,Moises Hur,Sungwon Hur et al.
Fei Ji et al.
Multiplex protein imaging technologies enable deep phenotyping and provide rich spatial information about biological samples. Existing methods have shown great success but also harbored trade-offs between various pros and cons, underscoring...
Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis [0.03%]
耐d-环丝氨酸变异体D322N的丙氨酸消旋酶的空间结构（来源于结核杆菌）
Cesira de Chiara,Gareth A Prosser,Roksana Ogrodowicz et al.
Cesira de Chiara et al.
Alanine racemase (Alr) is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes the racemization of l-alanine to d-alanine. Alr is one of the two targets of the broad-spectrum antibiotic d-cycloserine (DCS), a structural analogue of d-al...
Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes [0.03%]
用于序列多样性莱基宁S-腺苷甲硫氨酸酶的功能统一的催化位点接近度谱分析
Timothy W Precord,Sangeetha Ramesh,Shravan R Dommaraju et al.
Timothy W Precord et al.
The radical S-adenosylmethionine (rSAM) superfamily has become a wellspring for discovering new enzyme chemistry, especially regarding ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we report a compendium ...
Activity-Based Photoacoustic Probes for Detection of Disease Biomarkers beyond Oncology [0.03%]
基于活性的光声探针用于检测肿瘤以外疾病的生物标志物
Michael C Lee,Kayla Landers,Jefferson Chan
Michael C Lee
The earliest activity-based photoacoustic (PA) probes were developed as diagnostic agents for cancer. Since this seminal work over a decade ago that specifically targeted matrix metalloproteinase-2, PA instrumentation, dye platforms, and pr...
Pre-Existing Oxidative Stress Creates a Docking-Ready Conformation of the SARS-CoV-2 Receptor-Binding Domain [0.03%]
既存的氧化应激使SARS-CoV-2刺突蛋白受体结构域处于“待机结合”构象
Carl J Fossum,Bethany F Laatsch,Harrison R Lowater et al.
Carl J Fossum et al.
The redox-dependent changes on the binding between the receptor-binding domain of the severe acute respiratory syndrome-coronavirus-2 spike protein and the peptidase domain of the human cell surface receptor angiotensin-converting enzyme II...
Correction to "Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation" [0.03%]
Correction of “参与厌氧血红素降解的SAM-E结合甲基转移酶C亚类”
Liju G Mathew,Marley Brimberry,William N Lanzilotta
Liju G Mathew
[This corrects the article DOI: 10.1021/acsbiomedchemau.1c00047.]. © 2022 The Authors. Published by American Chemical Society.
Published Erratum
ACS bio & med chem Au. 2022 May 9;2(6):655. DOI:10.1021/acsbiomedchemau.2c00025 2022
How a Subfamily of Radical S-Adenosylmethionine Enzymes Became a Mainstay of Ribosomally Synthesized and Post-translationally Modified Peptide Discovery [0.03%]
一个激进S-腺苷甲硫氨酸酶亚家族如何成为核糖体合成和翻译后修饰肽发现的基石
Aigera Mendauletova,Anastasiia Kostenko,Yi Lien et al.
Aigera Mendauletova et al.
Radical S-adenosylmethionine (rSAM) enzymes are a large and diverse superfamily of enzymes, some of which are known to participate in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). Specifical...
Amphiphilic Membrane Environments Regulate Enzymatic Behaviors of Salmonella Outer Membrane Protease [0.03%]
两亲性膜环境调控沙门氏菌外膜蛋白酶的酶学行为
Siau Ling Kum,James C S Ho,Atul N Parikh et al.
Siau Ling Kum et al.
The role of an amphiphilic environment in the functional regulation of integral membrane proteins is well appreciated but how specific amphiphilic surrounding influences the conformational plasticity and function of a protein is less obviou...
Squire J Booker
Squire J Booker