Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 [0.03%]
基于结构的m6A RNA书写酶METTL3抑制剂的设计
Rajiv Kumar Bedi,Danzhi Huang,Yaozong Li et al.
Rajiv Kumar Bedi et al.
Methyltransferase-like 3 (METTL3) and METTL14 form a heterodimeric complex that catalyzes the most abundant internal mRNA modification, N6-methyladenosine (m6A). METTL3 is the catalytic subunit that binds the co-substrate S-adenosyl methion...
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity [0.03%]
噻唑烷二酮酯类前药及其衍生肽的合成与活性研究
Andrew V Stachulski,Jean-Francois Rossignol,Sophie Pate et al.
Andrew V Stachulski et al.
Amino acid ester prodrugs of the thiazolides, introduced to improve the pharmacokinetic parameters of the parent drugs, proved to be stable as their salts but were unstable at pH > 5. Although some of the instability was due to simple hydro...
Design and Synthesis of Copper Nanobiomaterials with Antimicrobial Properties [0.03%]
具有抗菌性能的铜纳米生物材料的设计与合成
Clara Ortega-Nieto,Noelia Losada-Garcia,Benevides C Pessela et al.
Clara Ortega-Nieto et al.
In this work, nanostructured copper materials have been designed, synthetized, and evaluated in order to produce a more efficient and sustainable copper bionanohybrid with catalytical and antimicrobial properties. Thus, conditions are sough...
Irene Y Lee,Piyapa Tantisirivat,Laura E Edgington-Mitchell
Irene Y Lee
Protease-activated receptors (PARs) comprise a family of four G protein-coupled receptors (GPCRs) that have broad functions in health and disease. Unlike most GPCRs, PARs are uniquely activated by proteolytic cleavage of their extracellular...
Chemoenzymatic Synthesis of 3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP) [0.03%]
3'-脱氧-3'，4'-去氢胞苷三磷酸(ddhCTP)的化学生物合成法
James H Lee,James M Wood,Steven C Almo et al.
James H Lee et al.
3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin during the early stages of the innate immune response. ddhCTP has been shown to act as a chain terminator of flavivirus RNA...
Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications [0.03%]
响应氢硫酸的光疗剂：设计策略与生物应用
Musa Dirak,Sarp E Turan,Safacan Kolemen
Musa Dirak
Hydrogen sulfide (H2S) is one of the critical gasotransmitters, which play important roles in regular physiological processes, especially in vital signaling pathways. However, fluctuations in endogenous H2S concentration can be linked to se...
X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences [0.03%]
AT碱基对序列选择性识别的X射线结构特征分析
Edwin N Ogbonna,Ananya Paul,Abdelbasset A Farahat et al.
Edwin N Ogbonna et al.
The rational design of small molecules that target specific DNA sequences is a promising strategy to modulate gene expression. This report focuses on a diamidinobenzimidazole compound, whose selective binding to the minor groove of AT DNA s...
Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: In Silico and In Vitro Studies [0.03%]
对于desine和Riboprine表现出强大的抗SARS-CoV-2再利用潜力：基于计算机和体外研究
Amgad M Rabie,Mohnad Abdalla
Amgad M Rabie
Lately, nucleos(t)ide antivirals topped the scene as top options for the treatment of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Targeting the two broadly conser...
Riley B Hargreaves,Sam Duwé,Ashley M Rozario et al.
Riley B Hargreaves et al.
Standard optical imaging is diffraction-limited and lacks the resolving power to visualize many of the organelles and proteins found within the cell. The advent of super-resolution techniques overcame this barrier, enabling observation of s...
Template-Based Porous Hydrogel Microparticles as Carriers for Therapeutic Proteins [0.03%]
基于模板的多孔水凝胶微粒作为治疗蛋白载体
Philippe Delbreil,Xavier Banquy,Davide Brambilla
Philippe Delbreil
Hydrogels have been extensively researched for over 60 years for their limitless applications in biomedical research. In this study, porous hydrogel microparticles (PHMPs) made of poly(ethylene glycol) diacrylamide were investigated for the...