Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors [0.03%]
基于形状的虚拟筛选出一百亿化合物库中结核分枝杆菌硫胺素脱氢酶抑制剂
Mayako Michino,Alexandre Beautrait,Nicholas A Boyles et al.
Mayako Michino et al.
Lpd (lipoamide dehydrogenase) in Mycobacterium tuberculosis (Mtb) is required for virulence and is a genetically validated tuberculosis (TB) target. Numerous screens have been performed over the last decade, yet only two inhibitor series ha...
N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis [0.03%]
具有广谱活性和多种机制的N4-取代哌嗪诺氟沙星衍生物，作用于DNA回旋酶、拓扑异构酶IV及细菌细胞壁合成
Ahmed M Kamal El-Sagheir,Ireny Abdelmesseh Nekhala,Mohammed K Abd El-Gaber et al.
Ahmed M Kamal El-Sagheir et al.
Fluoroquinolones are an important class of antibiotics with broad-spectrum antibacterial and antitubercular activity. Here, we describe the design and synthesis of a series of 38 N4-substituted piperazinyl norfloxacin derivatives. Their act...
Biswanath Maity,Hariharan Moorthy,Thimmaiah Govindaraju
Biswanath Maity
Efficient delivery of bioactive ingredients into cells is a major challenge. Cell-penetrating peptides (CPPs) have emerged as promising vehicles for this purpose. We have developed novel CPPs derived from the flexible and disordered tail ex...
Size-Specific Modulation of a Multienzyme Glucosome Assembly during the Cell Cycle [0.03%]
细胞周期中多酶糖基组装体的尺寸特异性调节
Miji Jeon,Danielle L Schmitt,Minjoung Kyoung et al.
Miji Jeon et al.
Enzymes in glucose metabolism have been subjected to numerous studies, revealing the importance of their biological roles during the cell cycle. However, due to the lack of viable experimental strategies for measuring enzymatic activities p...
Macrocyclic Peptides Closed by a Thioether-Bipyridyl Unit That Grants Cell Membrane Permeability [0.03%]
用于细胞膜穿过的含有噻基-联吡啶单元的环肽
Hongxue Chen,Takayuki Katoh,Hiroaki Suga
Hongxue Chen
Membrane permeability is an important factor that determines the virtue of peptides targeting intracellular molecules. By introducing a membrane penetration motif, some peptides exhibit better membrane permeabilities. Previous choices for s...
Functional Diversity in Radiolabeled Nanoceramics and Related Biomaterials for the Multimodal Imaging of Tumors [0.03%]
放射标记纳米陶瓷及其相关生物材料的多功能性用于肿瘤多模态成像
David G Calatayud,Marina Lledos,Federico Casarsa et al.
David G Calatayud et al.
Nanotechnology advances have the potential to assist toward the earlier detection of diseases, giving increased accuracy for diagnosis and helping to personalize treatments, especially in the case of noncommunicative diseases (NCDs) such as...
Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes [0.03%]
靶向SHP2活性位点抑制剂阻断信号传导和乳腺癌细胞表型
Dhanaji M Lade,Yehenew M Agazie
Dhanaji M Lade
The Src homology phosphotyrosyl phosphatase 2 (SHP2) is an oncogenic protein for which targeted therapies are being sought. In line with this idea, we have previously reported the development of a specific active site inhibitor named CNBDA ...
Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents [0.03%]
研究结核分支杆菌鸟嘌呤磷酸核糖转移酶活化位点残基的作用及其作为抗结核药物靶点的潜力
David W Konas,Sarah Cho,Oshane D Thomas et al.
David W Konas et al.
Mycobacterium tuberculosis drug resistance is emerging and new drug targets are needed. Tryptophan biosynthesis is necessary for M. tuberculosis replication and virulence. Indole-3-glycerol phosphate synthase (IGPS) catalyzes a step in M. t...
Cytochromes P450 Associated with the Biosyntheses of Ribosomally Synthesized and Post-translationally Modified Peptides [0.03%]
与核糖体合成和翻译后修饰肽类生物合成相关联的细胞色素P450酶
Guannan Zhong
Guannan Zhong
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a class of exponentially increased natural products with characteristic chemical structures, topologies, and biosynthetic mechanisms as well as exceptional bioac...
Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide [0.03%]
硫代 mustard 衍生物乙基氯乙硫醚的高效中和剂甲巯咪唑
Albert Armoo,Tanner Diemer,Abigail Donkor et al.
Albert Armoo et al.
Sulfur mustard (SM), designated by the military as HD, is a highly toxic and dangerous vesicant that has been utilized as a chemical warfare agent since World War I. Despite SM's extensive history, an effective antidote does not exist. The ...