Mass Spectrometry-Based Protein Footprinting Defines the Binding Pocket of Crotonylated H3K14 in the PHD1 Domain of BAF45D within the BAF Chromatin Remodeling Complex [0.03%]
基于质量谱的蛋白质印记定义了BAF染色质重塑复合物中的BAF45D的PHD1域内丙酰化H3K14结合袋
Marissa R Martinez,Janna Kiselar,Benlian Wang et al.
Marissa R Martinez et al.
The BRG-/BRM-associated factor (BAF) chromatin remodeling complex is a central actor in transcription. One mechanism by which BAF affects gene expression is via its various histone mark readers, including double plant homeodomains (DPF), lo...
Triblock Glycopolymers with Two 10-mer Blocks of Activating Sugars Enhance the Activation of Acrosomal Exocytosis in Mouse Sperm [0.03%]
两种活化糖十聚体嵌段的三嵌段甘露聚糖可增强小鼠精子顶体反应
Luz C Mendez,Mitchell Kennedy,Surita R Bhatia et al.
Luz C Mendez et al.
Carbohydrate recognition is imperative for the induction of sperm acrosomal exocytosis (AE), an essential phenomenon in mammalian fertilization. In mouse sperm, polynorbornene 100-mers displaying fucose or mannose moieties were effective at...
Effects of Strigolactones on NLRP3 Activation, Nitrosative Stress, and Antioxidant Mox Phenotype: In Vitro and In Silico Evidence [0.03%]
独脚金内酯对NLRP3激活、硝化应激和抗氧化Mox表型的影响：体外和分子证据
Gizem Antika,Zeynep Özlem Cinar,Serhat Dönmez et al.
Gizem Antika et al.
Phytohormones have significant roles in redox metabolism, inflammatory responses, and cellular survival mechanisms within the microenvironment of the mammalian brain. Herein, we identified the mammalian molecular targets of three representa...
Genetic Targets and Applications of Iron Chelators for Neurodegeneration with Brain Iron Accumulation [0.03%]
针对脑铁沉积神经退行性疾病的遗传靶点与铁螯合剂的应用
Neharika Marupudi,May P Xiong
Neharika Marupudi
Neurodegeneration with brain iron accumulation (NBIA) is a group of neurodegenerative diseases that are typically caused by a monogenetic mutation, leading to development of disordered movement symptoms such as dystonia, hyperreflexia, etc....
Enhanced Sequence-Specific DNA Recognition Using Oligodeoxynucleotide-Benzimidazole Conjugates [0.03%]
利用寡脱氧核糖核酸-苯并咪唑缀合物增强序列特异性DNA识别能力
Souvik Sur,Suresh Pujari,Nihar Ranjan et al.
Souvik Sur et al.
Synthetic modification of oligodeoxynucleotides (ODNs) via conjugation to nucleic acid binding small molecules can improve hybridization and pharmacokinetic properties. In the present study, five Hoechst 33258 derived benzimidazoles were co...
Differences in the Membrane-Binding Properties of Flaviviral Nonstructural 1 (NS1) Protein: Comparative Simulations of Zika and Dengue Virus NS1 Proteins in Explicit Bilayers [0.03%]
黄病毒非结构1（NS1）蛋白膜结合性质的差异：寨卡和登革热病毒NS1在显式双层膜上的比较模拟研究
Rajagopalan Muthukumaran,Ramasubbu Sankararamakrishnan
Rajagopalan Muthukumaran
NS1 in flaviviruses is the only nonstructural protein that is secretory and interacts with different cellular components of the host cell membrane. NS1 is localized in the ER as a dimer to facilitate viral replication. Crystal structures of...
Advancing In Situ Analysis of Biomolecular Corona: Opportunities and Challenges in Utilizing Field-Flow Fractionation [0.03%]
原位分析生物分子冠的新机遇和挑战——利用场流分离技术的前景与挑战
Soheyl Tadjiki,Shahriar Sharifi,Afsaneh Lavasanifar et al.
Soheyl Tadjiki et al.
The biomolecular corona, a complex layer of biological molecules, envelops nanoparticles (NPs) upon exposure to biological fluids including blood. This dynamic interface is pivotal for the advancement of nanomedicine, particularly in areas ...
High-Fidelity Assay Based on Turn-Off Fluorescence to Detect the Perturbations of Cellular Proteostasis [0.03%]
一种基于荧光淬灭的检测细胞蛋白质稳态紊乱的高保真分析法
Conner Hoelzel,Yulong Bai,Mengdie Wang et al.
Conner Hoelzel et al.
The persistence of neurodegenerative diseases has necessitated the development of new strategies to monitor protein homeostasis (proteostasis). Previous efforts in our laboratory have focused on the development of fluorogenic strategies to ...
Francesco Nai,Maria Paula Flores Espinoza,Annalisa Invernizzi et al.
Francesco Nai et al.
We discovered the first inhibitors of the m7G-RNA writer METTL1 by high-throughput docking and an enzymatic assay based on luminescence. Eleven compounds, which belong to three different chemotypes, show inhibitory activity in the range 40-...
Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins [0.03%]
用于万古霉素结合蛋白鉴定的重氮化合物光探针
Photis Rotsides,Paula J Lee,Nakoa Webber et al.
Photis Rotsides et al.
Vancomycin's interactions with cellular targets drive its antimicrobial activity and also trigger expression of resistance against the antibiotic. Interaction partners for vancomycin have previously been identified using photoaffinity probe...