Synthesis and Modification of Cordycepin-Phosphoramidate ProTide Derivatives for Antiviral Activity and Metabolic Stability [0.03%]
虫草素-磷酰胺酯前药衍生物的合成及改性在抗病毒活性和代谢稳定性中的应用
Aticha Thiraporn,Thanat Tiyasakulchai,Thitiphong Khamkhenshorngphanuch et al.
Aticha Thiraporn et al.
In our study, Prodrug nucleoTide (ProTide) technology was applied to cordycepin to enhance its antiviral activities and metabolic stability. Using cordycepin as starting material, we developed a synthetic method to access a series of stereo...
Cation Pretreatment Enables the Saline Stability of a Near-Infrared Sensor for Dopamine [0.03%]
阳离子预处理实现了用于检测多巴胺的近红外传感器在盐水中的稳定性
Xuewen Liu,Jing Chen,Hanxuan Wang et al.
Xuewen Liu et al.
Single-walled carbon nanotubes (SWCNTs) are wrapped with single-stranded DNA (ssDNA) to create near-infrared (NIR-II) fluorescent sensors for diverse analytes. However, the interaction between the negatively charged backbone of ssDNA and ca...
Probing the Limits of Reactant Concentration and Volume in Primitive Polyphenyllactate Synthesis and Microdroplet Assembly Processes [0.03%]
探究原始聚苯乳酸合成及微液滴组装过程中反应物浓度和体积的极限条件
Mahendran Sithamparam,Rehana Afrin,Navaniswaran Tharumen et al.
Mahendran Sithamparam et al.
Polyester microdroplets have been investigated as primitive protocell models that can exhibit relevant primitive functions such as biomolecule segregation, coalescence, and salt uptake. Such microdroplets assemble after dehydration synthesi...
Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61 [0.03%]
探索SARS-CoV-2主蛋白酶(Mpro)的可能耐药变异体与非共价临床前候选药物Mpro61的关系
Jessica R Kenneson,Christina Papini,Su Tang et al.
Jessica R Kenneson et al.
SARS-CoV-2 Mpro inhibitors, such as nirmatrelvir, have proven efficacy in clinical use. Nirmatrelvir was developed in a target-based approach against wild-type Mpro, with the anticipation that prolonged usage may cause enrichment of drug-re...
Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context of in Vitro Bladder Epithelial Cell Infection [0.03%]
xylocaine对体外膀胱上皮细胞感染的抑菌和免疫调节作用研究
John Kerr White,Yundi Yin,Soumitra Mohanty et al.
John Kerr White et al.
The application of urinary catheters is associated with pain and discomfort. Several topical medications are available to ease catheter insertion, including xylocaine. Here we report that xylocaine, although not classified as an antibacteri...
Metabolic Probing of Sialylated Glycoconjugates with Fluorine-Selenol Displacement Reaction (FSeDR) [0.03%]
氟硒醇置换反应(FSeDR)对唾液酸化糖缀合物的代谢探针研究
Yue Zhao,Zhigang Lyu,Benjamin Prather et al.
Yue Zhao et al.
Dysregulated sialic acid biosynthesis is characteristic of the onset and progression of human diseases including hormone-sensitive prostate cancer and breast cancer. The sialylated glycoconjugates involved in this process are therefore impo...
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA [0.03%]
用于细胞内丙二酰辅酶A检测的基因编码荧光生物传感器
Brodie L Ranzau,Tiffany D Robinson,Jack M Scully et al.
Brodie L Ranzau et al.
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through protein malonylation and allosteric regulation of signaling networks. Accordingly, the production and use of malonyl-CoA is finely tuned by the c...
Antigenicity Extension: A Novel Concept Explained by the Immunogenicity of PEG [0.03%]
抗原扩展性：一个可以通过PEG的免疫原性来解释的新概念
Kouichi Shiraishi,Masayuki Yokoyama
Kouichi Shiraishi
Poly(ethylene glycol)-related immune responses have been a great concern regarding mRNA vaccination for the SARS-CoV2 virus, because PEG-lipids are an essential component for the lipid nanoparticles of mRNA vaccines. Meanwhile, no research ...
Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes [0.03%]
细胞色素P450酶催化C-N和C-S键构建的机制视角
Tai-Ping Zhou,Yakun Fan,Jinyan Zhang et al.
Tai-Ping Zhou et al.
Cytochrome P450 enzymes catalyze a large number of oxidative transformations that are responsible for natural product synthesis. Recent studies have revealed their unique ability to catalyze the formation of C-N and C-S bonds, broadening th...
Ex Vivo Delivery of mRNA to Immune Cells via a Nonendosomal Route Obviates the Need for Nucleoside Modification [0.03%]
无需核苷修饰通过非内体途径向免疫细胞递送mRNA
Bartika Ghoshal,Debajyoti Chakraborty,Manish Nag et al.
Bartika Ghoshal et al.
Base modification and the use of lipid nanoparticles are thought to be essential for efficient in vivo delivery and expression of mRNA. However, for ex vivo immune cell engineering, the need for either of the two is unclear. Previous report...