Beyond the classical amyloid hypothesis in Alzheimer's disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models [0.03%]
超越阿尔茨海默病的古典淀粉样蛋白假说：对目前发病机制概念、治疗靶点和研究模型的分子见解
Atsadang Theerasri,Sakawrat Janpaijit,Tewin Tencomnao et al.
Atsadang Theerasri et al.
Alzheimer's disease (AD) is one of the progressive neurodegenerative disorders and the most common cause of dementia in the elderly worldwide causing difficulties in the daily life of the patient. AD is characterized by the aberrant accumul...
Human globozoospermia-related genes and their role in acrosome biogenesis [0.03%]
人类全精子症相关基因及其在顶体形成中的作用
Ricardo D Moreno
Ricardo D Moreno
The mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire pro...
Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research [0.03%]
男性生殖系统的类器官：挑战、机遇及其在生育研究中的潜在应用
Daniela Patrício,Joana Santiago,João F Mano et al.
Daniela Patrício et al.
Organoids are units of function of a given organ able to reproduce, in culture, a biological structure similar in architecture and function to its counterpart in vivo. Today, it is possible to develop an organoid from a fragment of tissue, ...
Determination of the Salmonella intracellular lifestyle by the diversified interaction of Type III secretion system effectors and host GTPases [0.03%]
II型分泌系统效应蛋白与宿主GTP酶的多样互作决定沙门氏菌胞内生存方式
Kun Meng,Ping Zhu,Liuliu Shi et al.
Kun Meng et al.
Intracellular bacteria have developed sophisticated strategies to subvert the host endomembrane system to establish a stable replication niche. Small GTPases are critical players in regulating each step of membrane trafficking events, such ...
Insights into the sperm chromatin and implications for male infertility from a protein perspective [0.03%]
从蛋白质角度探讨精子染色质的奥秘及其对男性不育的影响
Alberto de la Iglesia,Meritxell Jodar,Rafael Oliva et al.
Alberto de la Iglesia et al.
Male germ cells undergo an extreme but fascinating process of chromatin remodeling that begins in the testis during the last phase of spermatogenesis and continues through epididymal sperm maturation. Most of the histones are replaced by sm...
Ramanuj DasGupta,Aixin Yap,Elena Yong Yaqing et al.
Ramanuj DasGupta et al.
Cancer treatment is gradually evolving from the classical use of nonspecific cytotoxic drugs targeting generic mechanisms of cell growth and proliferation. Instead, new "patient-specific treatment paradigms" that are based on an individual ...
In silico modeling for the hepatic circulation and transport: From the liver organ to lobules [0.03%]
肝脏血液循环和转运的计算机模拟：从肝到肝小叶
Harvey Ho,Shawn Means,Soroush Safaei et al.
Harvey Ho et al.
The function of the liver depends critically on its blood supply. Numerous in silico models have been developed to study various aspects of the hepatic circulation, including not only the macro-hemodynamics at the organ level, but also the ...
Regenerative mesenchymal stem cell-derived extracellular vesicles: A potential alternative to cell-based therapy in viral infection and disease damage control [0.03%]
具有再生能力的间充质干细胞来源的外泌体：作为细胞治疗在病毒感染及疾病损伤控制中的潜在替代品
Ayodeji O Ipinmoroti,Rachana Pandit,Qiana L Matthews
Ayodeji O Ipinmoroti
Extracellular vesicles (EVs) released by regenerative cells such as mesenchymal stem cells are effective facilitators of healing, therapy, and repair. Conversely, EVs released from infected and/or diseased cells could be useful as markers i...
Aditi Agrawal,Ken Wang,Liudmila Polonchuk et al.
Aditi Agrawal et al.
The L-type calcium current ( I CaL ) plays a critical role in cardiac electrophysiology, and models of I CaL are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling I CaL have res...
Peng Jin,Jennifer M Munson
Peng Jin
Interstitial fluid (IF) and cerebrospinal fluid (CSF) are an integral part of the brain, serving to cushion and protect the brain parenchymal cells against damage and aid in their function. The brain IF contains various ions, nutrients, was...