Galectin-9 Modulates Autoimmunity: Roles in Tissue Inflammation and Organ Involvement [0.03%]
半乳糖凝集素9调节自身免疫：在组织炎症和脏器受累中的作用
Fangyu Liu,Xuanyi Zhou,Jing Luo et al.
Fangyu Liu et al.
Galectin-9 (Gal9) is a type of animal lectin that binds terminal β-galactosides and is involved in immunoregulatory functions. Clinically, Gal9 levels are positively correlated with disease activity in systemic autoimmune diseases, and it ...
Friend or Foe? The Dual Role of Ferroptosis in Tumor Immunity and Immunotherapy [0.03%]
双刃剑：铁死亡在肿瘤免疫和免疫治疗中的双重作用
Fangyu Liu,Mairepaiti Halimulati,Jing Luo et al.
Fangyu Liu et al.
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, plays a context-dependent dual role in tumor immunity and immunotherapy. On one hand, it can act as an immunogenic cell death mechanism, releasing dam...
Nager Syndrome Revisited: Integrating In Vivo and In Vitro Models to Decipher SF3B4-Dependent Tissue Coordination [0.03%]
纳格综合征再探：整合体内和体外模型以解析SF3B4依赖性组织协调作用
Jingru Qin,Zulvikar Syambani Ulhaq,William Ka Fai Tse
Jingru Qin
Nager syndrome (NS) is a rare congenital disorder primarily characterized by mandibulofacial dysostosis and upper limb anomalies. Pathogenic variants in SF3B4, which encodes a core spliceosomal component, represent the primary known genetic...
Anna Karenina Principle, Immune-Oncology-Microbiome Trio and Cancer Microbiome Therapy [0.03%]
安娜卡列尼娜原则、免疫-肿瘤-微生物组三联体与癌症微生物疗法
Zhanshan Sam Ma
Zhanshan Sam Ma
The immune-oncology-microbiome (IOM) trio highlights the significant role of microbiomes in cancer progression by modulating immune evasion, genomic instability, and inflammation-key hallmarks of cancer. While microbiomes can exert both pro...
Youness Limami,Hicham Wahnou,Martin Ndayambaje et al.
Youness Limami et al.
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has revealed the virus's ability to induce multi-organ damage, including significant liver injury. The molecular m...
Marvin J Menjivar-Vallecillo,Nadia V Padilla-Claros,Pilar Gavarrete-Garrido et al.
Marvin J Menjivar-Vallecillo et al.
The nucleolus, traditionally known for its role in ribosome biogenesis, is now recognized for its broader functions, including cellular stress adaptation and its involvement in various pathological processes, such as ribosomal alterations, ...
Biomedical Models: Use of Zebrafish as a Multi-Utility In Vivo Tool Box [0.03%]
斑马鱼作为多效性整体实验工具箱在生物医学模型中的应用
Barsha Mohanty,Masmarika Mohan,Dechamma Pandyanda Nanjappa et al.
Barsha Mohanty et al.
Molecular research has gradually revealed the biological significance of genetically encoded information and how this information is transmitted and utilized in a cell. The scientific advances of the last few decades have brought about para...
Harnessing Noncanonical Proteins for Next-Generation Drug Discovery and Diagnosis [0.03%]
非 canonical 蛋白在下一代药物发现和诊断中的应用
Nachiket Rajinikanth,Ruchi Chauhan,Sudhakaran Prabakaran
Nachiket Rajinikanth
Noncanonical proteins, encoded by previously overlooked genomic regions (part of the "dark genome"), are emerging as crucial players in human health and disease, expanding our understanding of the "dark proteome." This review explores their...
Mechanical Forces in Tumor Growth and Treatment: Perspectives From Biology, Physics, Engineering, and Mathematical Modeling [0.03%]
肿瘤生长和治疗中的机械力：来自生物学、物理学、工程学和数学建模的视角
Farshad Moradi Kashkooli,Fatemeh Mirala,Masoud H H Tehrani et al.
Farshad Moradi Kashkooli et al.
The progression of tumors is influenced by mechanical forces and biological elements, such as hypoxia and angiogenesis. Mechanical factors, including stress, pressure, interstitial fluid pressure, and cellular traction forces, compromise no...
Host-Pathogen Interaction Databases: Tools for Rapid Understanding of Microbial Pathogenesis [0.03%]
宿主病原交互数据库：快速理解微生物致病机制的工具
Abdul Arif Khan,Pooja Wakchoure,Fozia Farooq et al.
Abdul Arif Khan et al.
Understanding of microbial pathogenesis has greatly revolutionized after conventional culture-based techniques are replaced by molecular methods. This technological shift is generating huge host-pathogen interactions (HPIs) data. Moreover, ...