The yeast-human coevolution: Fungal transition from passengers, colonizers, and invaders [0.03%]
酵母与人的协同进化：从乘客、殖民者到入侵者的真菌转变
Stefano Nenciarini,Sonia Renzi,Monica di Paola et al.
Stefano Nenciarini et al.
Fungi are the cause of more than a billion infections in humans every year, although their interactions with the host are still neglected compared to bacteria. Major systemic fungal infections are very unusual in the healthy population, due...
Appropriate patient population for future visual system axon regeneration therapies [0.03%]
视觉系统轴突再生疗法的适宜患者人群
Sanjoy K Bhattacharya,Chrisfouad Raif Alabiad,Krishna Kishor
Sanjoy K Bhattacharya
A number of blinding diseases caused by damage to the optic nerve result in progressive vision loss or loss of visual acuity. Secondary glaucoma results from traumatic injuries, pseudoexfoliation or pigmentary dispersion syndrome. Progressi...
Computational modeling of angiogenesis: The importance of cell rearrangements during vascular growth [0.03%]
血管生长过程中血管生成计算模型的研究：细胞重组的重要性
Daria Stepanova,Helen M Byrne,Philip K Maini et al.
Daria Stepanova et al.
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from the pre-existing vasculature to create new vascular networks. In addition to its essential role in normal development, angiogenesis plays a vital ro...
A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices [0.03%]
从基因组发现到脑机接口和深部大脑刺激装置靶点的展望
Wander L Valentim,Daniel S Tylee,Renato Polimanti
Wander L Valentim
Mental illnesses have a huge impact on individuals, families, and society, so there is a growing need for more efficient treatments. In this context, brain-computer interface (BCI) technology has the potential to revolutionize the options f...
Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment [0.03%]
大麻素与当前黑色素瘤治疗药物疗法耦合效应的前瞻性研究
Ava Bachari,Nazim Nassar,Ellen Schanknecht et al.
Ava Bachari et al.
Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted a...
Synaptic plasticity and the role of astrocytes in central metabolic circuits [0.03%]
突触可塑性与星形胶质细胞在中枢代谢回路中的作用
Dominique Ameroso,Maribel Rios
Dominique Ameroso
Neural circuits in the brain, primarily in the hypothalamus, are paramount to the homeostatic control of feeding and energy utilization. They integrate hunger, satiety, and body adiposity cues from the periphery and mediate the appropriate ...
MHC class III lymphocyte antigens 6 as endogenous immunotoxins: Unlocking immunotherapy in proficient mismatch repair colorectal cancer [0.03%]
MHC类III淋巴细胞抗原6作为内源性免疫毒素：在熟练的错配修复型结直肠癌中解锁免疫治疗
Guido Giordano,Massimo Pancione
Guido Giordano
A majority of cancers, including colorectal cancer (CRC) with intact DNA mismatch repair, exhibit a paralyzed antitumor immune response and resistance to immune checkpoint inhibitors. Members of MHC class III lymphocyte antigen 6G (LY6G) en...
iPSCs as a groundbreaking tool for the study of adverse drug reactions: A new avenue for personalized therapy [0.03%]
诱导多能干细胞在药物不良反应研究中的开创性应用及个性化治疗的新途径
Paola Rispoli,Tatiana Scandiuzzi Piovesan,Giuliana Decorti et al.
Paola Rispoli et al.
Induced pluripotent stem cells (iPSCs), obtained by reprogramming different somatic cell types, represent a promising tool for the study of drug toxicities, especially in the context of personalized medicine. Indeed, these cells retain the ...
Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond [0.03%]
二十年的心脏再生研究：心肌细胞增殖及其它方向
Herman Huang,Guo N Huang,Alexander Y Payumo
Herman Huang
Interest in vertebrate cardiac regeneration has exploded over the past two decades since the discovery that adult zebrafish are capable of complete heart regeneration, contrasting the limited regenerative potential typically observed in adu...
Secondary glaucoma: Toward interventions based on molecular underpinnings [0.03%]
继发性青光眼：基于分子机制的干预措施研究
Anna Mueller,Isabel Lam,Krishna Kishor et al.
Anna Mueller et al.
Glaucoma is a heterogeneous group of progressive diseases that leads to irreversible blindness. Secondary glaucoma refers to glaucoma caused by a known underlying condition. Pseudoexfoliation and pigment dispersion syndromes are common caus...