Philip Barrett,Ke&#x;ale W Louie,Jean-Baptiste Dupont et al.
Philip Barrett et al.
Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by mutations in the DMD gene, which encodes dystrophin. Despite its initial description in the late 19th century by French neurologist Guillaume Duchenne de Bo...
The noncanonical NFκB pathway: Regulatory mechanisms in health and disease [0.03%]
非经典的NF-κB信号转导途径：调控机制及其在健康和疾病中的作用
Benancio N Rodriguez,Helen Huang,Jennifer J Chia et al.
Benancio N Rodriguez et al.
The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell survival, growth, maturation, and differentiation factors that are important for the development and maintenance of hematopoietic cells and immune or...
Paul Jerard Layug,Harman Vats,Kamali Kannan et al.
Paul Jerard Layug et al.
Biological sex is an important variable that influences the immune system's susceptibility to infectious and non-infectious diseases and their outcomes. Sex dimorphic features in innate and adaptive immune cells and their activities may hel...
SLC40A1 in iron metabolism, ferroptosis, and disease: A review [0.03%]
铁代谢、铁依赖性细胞死亡和疾病的SLC40A1调控机制：综述
Yan Zhang,Liyi Zou,Xiaodan Li et al.
Yan Zhang et al.
Solute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an o...
Advances in understanding immune homeostasis in latent tuberculosis infection [0.03%]
潜伏性结核感染中免疫稳态的理解进展
Liangfei Niu,Hao Wang,Geyang Luo et al.
Liangfei Niu et al.
Nearly one-fourth of the global population is infected by Mycobacterium tuberculosis (Mtb), and approximately 90%-95% remain asymptomatic as latent tuberculosis infection (LTBI), an estimated 5%-10% of those with latent infections will even...
Review of cardiac-coronary interaction and insights from mathematical modeling [0.03%]
心脏-冠状动脉相互作用的回顾及数学模型提供的见解
Lei Fan,Haifeng Wang,Ghassan S Kassab et al.
Lei Fan et al.
Cardiac-coronary interaction is fundamental to the function of the heart. As one of the highest metabolic organs in the body, the cardiac oxygen demand is met by blood perfusion through the coronary vasculature. The coronary vasculature is ...
The intersection of virus infection and liver disease: A comprehensive review of pathogenesis, diagnosis, and treatment [0.03%]
病毒感染与肝病的交叉：发病机制、诊断和治疗的全面回顾
Meng Ren,Chenxia Lu,Mingwei Zhou et al.
Meng Ren et al.
Liver disease represents a significant global burden, placing individuals at a heightened risk of developing cirrhosis and liver cancer. Viral infections act as a primary cause of liver diseases on a worldwide scale. Infections involving he...
Stefano Nenciarini,Sonia Renzi,Monica di Paola et al.
Stefano Nenciarini et al.
The fungal component of the microbiota, the mycobiota, has been neglected for a long time due to its poor richness compared to bacteria. Limitations in fungal detection and taxonomic identification arise from using metagenomic approaches, o...
Let's talk about sex: Mechanisms of neural sexual differentiation in Bilateria [0.03%]
谈谈性：双胚层动物神经性别分化的机制
Emma C Roggenbuck,Elijah A Hall,Isabel B Hanson et al.
Emma C Roggenbuck et al.
In multicellular organisms, sexed gonads have evolved that facilitate release of sperm versus eggs, and bilaterian animals purposefully combine their gametes via mating behaviors. Distinct neural circuits have evolved that control these phy...
Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin [0.03%]
与巨人同行：在巨型肌丝蛋白--titin中变异影响评估的挑战
Timir G R Weston,Martin Rees,Mathias Gautel et al.
Timir G R Weston et al.
Titin, the so-called "third filament" of the sarcomere, represents a difficult challenge for the determination of damaging genetic variants. A single titin molecule extends across half the length of a sarcomere in striated muscle, fulfillin...