Genetic and epigenetic landscape of O6-methylguanine-DNA methyltransferase (MGMT): implications for DNA repair and cancer therapeutics [0.03%]
O6-甲基鸟嘌呤-DNA-甲基转移酶(MGMT)的基因和表观遗传学图谱：对DNA修复及癌症治疗的意义
Shishir Singh,Rajeev Nema,Monisha Banerjee et al.
Shishir Singh et al.
O6-Methylguanine-DNA methyltransferase (MGMT) acts as a genomic custodian, reversing alkylation damage to preserve DNA integrity. However, when its regulatory balance tips via promoter methylation, polymorphisms, or epigenetic silencing, MG...
Inflammatory signatures across four photon radiotherapy and proton radiotherapy: mechanisms, mitigation, and quality of life impact [0.03%]
光子放射治疗和质子放射治疗的四种炎症标志物：机制、缓解和生活质量影响
Yuting Sheng,Daniel M Han,Mark R Wakefield et al.
Yuting Sheng et al.
Cancer is the second leading cause of death globally and in the United States, second only to cardiovascular disease. Unlike many cardiovascular conditions, cancer is often less preventable, manageable, and curable-even with ongoing technol...
Improvement of the sensitivity of circulating tumor DNA-based liquid biopsy: current approaches and future perspectives [0.03%]
基于循环肿瘤DNA的液体活检灵敏度改进：当前方法和未来前景
Ekaterina S Kuligina,Grigoriy A Yanus,Evgeny N Imyanitov
Ekaterina S Kuligina
Liquid biopsy (LB) is a complex of procedures aimed at the detection of tumor-derived fragments (nucleic acids, proteins, cells, etc.) persisting in the blood or other body fluids. It can be utilized for early cancer diagnosis, analysis of ...
Anti-angiogenic effects of Moringa oleifera silver nanoparticles on endothelial cells: in vitro and ex vivo studies [0.03%]
用体外和离体模型研究银摩雷迦油树纳米颗粒对内皮细胞的抗血管生成作用
Rolla Al-Shalabi,Vuanghao Lim,Ibrahim Al-Deeb et al.
Rolla Al-Shalabi et al.
Aim: Angiogenesis, invasion, and tube formation are critical processes in tumor progression and metastasis. The use of nanoparticles derived from natural products presents a promising approach for targeted cancer therapy....
Correlation between histopathological features and recurrence score according to menopausal status in HR+/HER2- breast cancer patients: a retrospective study [0.03%]
绝经状态与HR+/HER2-乳腺癌患者复发评分的病理组织学特征相关性研究：一项回顾性研究
Federica Martorana,Sabrina Nucera,Gianmarco Motta et al.
Federica Martorana et al.
Aim: Clinico-pathological features have traditionally guided prognosis and adjuvant therapy for breast cancer (BC) patients. In the past decade, genomic tests such as Oncotype DX entered clinical practice to refine risk s...
Elena V Preobrazhenskaya,Rimma S Mulkidjan,Fyodor A Zagrebin et al.
Elena V Preobrazhenskaya et al.
Aim: This study aimed at the identification of new druggable alterations in non-small cell lung carcinomas (NSCLCs). Methods: RNA next ...
Dysbiosis and colorectal cancer: conducive factors, biological and molecular role, and therapeutic prospectives [0.03%]
肠癌与菌群失调：促成因素、生物学和分子机制及其治疗前景
Gurkaranjot Singh,Zuhair Chaudhry,Anik Boyadzhyan et al.
Gurkaranjot Singh et al.
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States. Emerging evidence highlights the significant role of gut microbiota dysbiosis, characterized by a reduction in beneficial bacteria and an incre...
James Gutmans,Hiba Mechahougui
James Gutmans
Biliary tract cancers (BTCs) are aggressive malignancies associated with poor prognosis and limited treatment options. Advances in precision oncology, notably the identification of recurrent molecular alterations such as fibroblast growth f...
Comparison of outcomes of neoadjuvant chemotherapy in BRCA1- versus BRCA2-associated breast and ovarian cancers [0.03%]
BRCA1和BRCA2相关乳腺癌和卵巢癌新辅助化疗效果的比较分析
Anna Sokolenko,Tatiana Gorodnova,Diana Enaldieva et al.
Anna Sokolenko et al.
Aim: BRCA1/2-associated breast and ovarian carcinomas are often regarded as a single entity, assuming that BRCA1 and BRCA2 genes are almost equivalent with regard to their clinical significance. However, BRCA1 and BRCA2 g...
Guraustin S Brar,Aidan A Schmidt,Logan R Willams et al.
Guraustin S Brar et al.
Osteosarcoma is the most prevalent primary malignant bone tumor affecting adolescents and young adults. Despite advancements in cancer therapies, its prognosis remains poor due to its aggressive nature and early propensity for metastasis-of...