Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 E5, E6, and E7 oncogene expression in breast cancer [0.03%]
人乳头瘤病毒16型E5、E6和E7癌基因在乳腺癌中对PI3K/AKT/mTOR信号通路转录调控的调节作用
Beatriz Eda de Oliveira Isídio,Pedro Henrique Bezerra Fontes,Gabriel Rômulo Parente da Silva et al.
Beatriz Eda de Oliveira Isídio et al.
Aim: Breast cancer is the most prevalent malignant tumor among women. Human papillomavirus (HPV) has been detected in breast tumors since the 1990s, and beyond its oncogenic potential, therapy resistance driven by viral i...
Consensus statements on the definition, diagnosis, and management of oligoprogressive disease: results of an expert survey of Kazakhstan Cancer Society [0.03%]
关于寡进展性疾病定义、诊断和管理的共识声明：哈萨克斯坦肿瘤协会专家调查结果
Dilyara Kaidarova,Indira Omarova,Samat Kaldarbekov et al.
Dilyara Kaidarova et al.
Aim: Oligoprogressive disease (OPD) has emerged as a clinically relevant and common scenario in oncology, reflecting progression in a limited number of metastatic sites while systemic therapy continues to control the majo...
Dendritic cell-based immunotherapy modulates the systemic inflammatory profile in a 4T1 breast cancer model [0.03%]
基于树突状细胞的免疫治疗可调节4T1乳腺癌模型的小鼠全身性炎症反应
Tauana Christina Dias,Jéssica Ferreira Vieira,Katiane Tostes et al.
Tauana Christina Dias et al.
Aim: Breast cancer remains a major cause of cancer-related mortality in women, particularly in advanced stages where therapeutic options are limited. While immune checkpoint inhibitors (ICIs) have improved outcomes in a s...
Liquid biopsy in breast cancer: current biomarker platforms and clinical applications [0.03%]
循环液体活检技术在乳腺癌中的临床应用及面临的问题
Pritam Saha Podder,Debasree Bhadra,Canio Martinelli et al.
Pritam Saha Podder et al.
Breast cancer remains one of the leading causes of cancer-related mortality worldwide, and despite considerable advances in therapeutic strategies, the absence of reliable, minimally invasive diagnostic tools continues to limit early detect...
FGFR3 gene alteration and protein expression in upper urinary tract carcinoma: unsuitability of ureteroscopic biopsy specimens for FGFR3 RNA testing [0.03%]
上尿路癌中FGFR3基因改变及蛋白表达：内窥镜活检标本不适于FGFR3RNA检测
Makito Miyake,Yuki Oda,Nobutaka Nishimura et al.
Makito Miyake et al.
We aimed to evaluate the suitability of archival ureteroscopic (URS) biopsy specimens for fibroblast growth factor receptor 3 (FGFR3) biomarker analysis in upper urinary tract urothelial carcinoma. Thirty-six patients with upper urinary tra...
Paclitaxel and carboplatin after disease progression on immune checkpoint inhibitor for patients with metastatic urothelial carcinoma [0.03%]
免疫检查点抑制剂治疗后进展的转移性尿路上皮癌患者的紫杉醇和卡铂治疗
Albert Jang,Miguel Muniz,Megan Spychalla et al.
Albert Jang et al.
Aim: Despite advances with immune checkpoint inhibitor (ICI)-based regimens in the past decade, patients with metastatic urothelial cancer (mUC) face a poor prognosis with few approved options. Platinum-based chemotherapy...
Comparative outcomes of open, laparoscopic, and robot-assisted radical cystectomy using IPTW-adjusted trifecta and pentafecta metrics [0.03%]
使用IPTW调整的三重奏和五重奏指标进行开放手术、腹腔镜和机器人辅助根治性膀胱切除术的比较结果分析
Nobutaka Nishimura,Makito Miyake,Yuki Oda et al.
Nobutaka Nishimura et al.
Aim: Minimally invasive approaches for radical cystectomy (RC) have been increasingly adopted; however, comparative evidence regarding surgical quality and perioperative outcomes among open (ORC), laparoscopic (LRC), and ...
Distinct transcriptomic features of tumor and stromal cells in direct contact in luminal and triple-negative breast cancers [0.03%]
与管腔型和三阴性乳腺癌肿瘤细胞直接接触的间质细胞具有不同的转录组特征
Anna Yu Kalinchuk,Ivan A Patskan,Evgeniya S Grigorieva et al.
Anna Yu Kalinchuk et al.
Aim: The aim was to determine the transcriptomic features of tumor and stromal cells in direct contact within tumor nodules in luminal and triple-negative breast cancer. ...
Transurethral laser ablation using 980-nm diode laser for recurrent non-muscle invasive bladder cancer [0.03%]
980纳米半导体激光尿道内膀胱肿瘤切除术治疗复发性非肌层浸润性膀胱癌
Hideo Fukuhara,Syo Shimasaki,Erika Yamashita et al.
Hideo Fukuhara et al.
Aim: Transurethral laser ablation (TULA) for recurrent bladder cancer is a less invasive treatment method for patients. We report here our initial clinical experience with TULA for recurrent bladder cancer. ...
Can we now save the neck of OSCC T1-T2 patients? A narrative review of whether experimental techniques are on the way to clinical application [0.03%]
保存早期舌癌患者喉功能的手术治疗进展述评
Vincenzo Cuccurullo,Graziella Di Grezia,Gianluca Gatta et al.
Vincenzo Cuccurullo et al.
The molecular pathogenesis of oral squamous cell carcinoma (OSCC) is a complex process involving genetic alterations that accumulate over time. The clinical presentation and management of patients vary according to several pathological fact...