Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer [0.03%]
获得性他莫昔芬抵抗过程中15-羟基前列腺素去氢酶的下调及与ERα阳性乳腺癌不良预后的关联关系研究
Milene Volpato,Michele Cummings,Abeer M Shaaban et al.
Milene Volpato et al.
Aim: Tamoxifen (TAM) resistance remains a clinical issue in breast cancer. The authors previously reported that 15-hydroxyprostaglandin dehydrogenase (HPGD) was significantly downregulated in tamoxifen-resistant (TAMr) br...
Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors [0.03%]
开发PROTACs以解决BTK激酶抑制剂相关的临床限制问题
Rachael Arthur,Beatriz Valle-Argos,Andrew J Steele et al.
Rachael Arthur et al.
Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell receptor signaling and the irreversible BT...
Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms [0.03%]
针对mRNA翻译起始因子的抑制作为成熟B细胞肿瘤的一种新型治疗策略
Joe Taylor,Alison M Yeomans,Graham Packham
Joe Taylor
Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, targeted inhibition of mRNA translation is ...
The development and applications of circulating tumour cells, circulating tumour DNA and other emerging biomarkers for early cancer detection [0.03%]
循环肿瘤细胞、循环肿瘤DNA及其他新兴生物标志物在癌症早期检测中的应用及发展展望
Despite major improvements in cancer treatment, detection, and health promotion, the mortality rates of late-stage cancer remain high. This is a critical issue because a large proportion of cancer mortality is experienced by patients who ha...