Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer [0.03%]
乳腺癌激素治疗诱发脱发的临床特征、发病机制及治疗选择
Alfredo Rossi,Gemma Caro,Francesca Magri et al.
Alfredo Rossi et al.
Adjuvant hormonal therapy is one of the most important treatments of hormone-receptor-positive breast cancer and includes selective estrogen receptor modulators, aromatase inhibitors, and luteinizing hormone-releasing hormone analogs. In pa...
Performing oncological procedures during COVID-19 outbreak: a picture from an Italian cancer center [0.03%]
意大利癌症中心COVID-19疫情期间的肿瘤手术应对措施及经验总结
Maristella Bungaro,Valentina Bertaglia,Marco Audisio et al.
Maristella Bungaro et al.
Aim: Since SARS-CoV-2 infection rapidly spread around the world, Italy has quickly become one of the most affected countries. Healthcare systems introduced strict infection control measures to ensure optimal care, especia...
A review of molecularly targeted therapy in biliary tract carcinoma: what is the next step? [0.03%]
分子靶向治疗胆道癌的现状及未来展望：我们下一步该做什么？
Giacomo Aimar,Chiara Paratore,Clizia Zichi et al.
Giacomo Aimar et al.
Patients with unresectable biliary tract carcinomas (BTCs) have a poor prognosis with a median overall survival of fewer than 12 months following systemic chemotherapy. In recent years, the identification of distinct molecular alterations w...
Current options and future directions of systemic therapy for advanced biliary tract cancer [0.03%]
Advanced Biliary Tract Cancer系统治疗的现状和未来方向
Maria Giuseppina Prete,Antonella Cammarota,Antonio D&#x;Alessio et al.
Maria Giuseppina Prete et al.
Biliary tract cancers (BTCs) are aggressive tumors arising from different portions of the biliary tree and classified according to the anatomical location in intrahepatic (i) cholangiocarcinoma (CCA, iCCA), perihilar CCA (pCCA), and distal ...
Shan Zhou,Renxi Wang
Shan Zhou
Multiple myeloma (MM) is a malignant proliferative disease of monoclonal plasma cells (PCs) and is characterized by uncontrolled proliferation of PCs and excessive production of specific types of immunoglobulins. Since PCs are terminally di...
The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer [0.03%]
靶向抑制锌离子转运蛋白SLC39A信号通路以治疗内分泌耐药性乳腺癌的重要性
Samuel Jones,Georgia Farr,Thirayost Nimmanon et al.
Samuel Jones et al.
Aim: Zinc is a key secondary messenger that can regulate multiple signalling pathways within cancer cells, thus its levels need to be strictly controlled. The Zrt, Irt-like protein (ZIP, SLC39A) family of zinc transporter...
Matthew Willman,Jonathan Willman,Brandon Lucke-Wold
Matthew Willman
Endocrine resistant breast cancer metastasis continues to serve as a significant clinical challenge with high morbidity and mortality for patients. As the number of breast cancer cases continues to rise, the rate of brain metastasis has als...
Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model [0.03%]
乳腺癌模型中与AKT、ERα和细胞周期信号修饰相关的雌激素和HER激活增殖的伴随抵抗性
Kate M Moore,Vera Cerqueira,Kenneth G MacLeod et al.
Kate M Moore et al.
Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation. ...
B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells [0.03%]
慢性淋巴细胞白血病细胞依赖B细胞受体的颗粒抗原吞噬和呈递
Annabel R Minton,Lindsay D Smith,Dean J Bryant et al.
Annabel R Minton et al.
Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble antigens targeted from the B-cell receptor to T-...
Role of estrogen receptor coregulators in endocrine resistant breast cancer [0.03%]
雌激素受体共调节因子在内分泌抵抗性乳腺癌中的作用
Kristin A Altwegg,Ratna K Vadlamudi
Kristin A Altwegg
Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70-80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα). The steroid hormone estrogen [17β-estradiol (E2)] plays a vital role both in the initiati...