Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response [0.03%]
结合聚焦超声热疗、pFAR4-IL-12转染和类脂佐剂产生远隔免疫效应
Hai Doan Do,Corinne Marie,Stéphanie Bessoles et al.
Hai Doan Do et al.
Aim: Gene-based immunotherapy against cancer is limited by low gene transfer efficiency. In the literature, interleukin-12 (IL-12) encoding plasmid associated with sonoporation has been shown to enhance antitumoral activi...
Liquid biopsy in biliary tract cancer from blood and bile samples: current knowledge and future perspectives [0.03%]
胆管癌血液和胆汁样本的液体活检：现状与未来展望
Gianluca Arrichiello,Valeria Nacca,Fernando Paragliola et al.
Gianluca Arrichiello et al.
Biliary tract cancer (BTC) is an aggressive tumor characterized by a poor prognosis. In the latest years, targetable genetic alterations have been discovered in BTC patients, leading to the approval of new targeted therapies. Liquid biopsy,...
Advanced metastatic pancreatic neuroendocrine tumor treated successfully with peptide receptor radionuclide therapy: a case report [0.03%]
肽受体放射性核素治疗成功治疗晚期胰腺神经内分泌肿瘤1例报告
Amit Kumar,Shweta Tanwar,Sudhish Gupta et al.
Amit Kumar et al.
Neuroendocrine tumor (NET) is a rare tumor that has been observed in different sites such as lungs and throughout the gastrointestinal tract. Clinical features are usually non-specific and vary considerably depending upon the location of th...
Inês Soares de Pinho,Catarina Abreu,Inês Gomes et al.
Inês Soares de Pinho et al.
The most common breast cancer (BC) subtypes are hormone-dependent, being either estrogen receptor-positive (ER+), progesterone receptor-positive (PR+), or both, and altogether comprise the luminal subtype. The mainstay of treatment for lumi...
In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy [0.03%]
体外乳腺癌模型用于研究内分泌治疗耐药机制
Gary J Cheng,Euphemia Y Leung,Dean C Singleton
Gary J Cheng
The development of endocrine resistance is a common reason for the failure of endocrine therapies in hormone receptor-positive breast cancer. This review provides an overview of the different types of in vitro models that have been develope...
Management of lung cancer patients during COVID-19 pandemic: dos, don'ts and don't knows [0.03%]
新冠肺炎疫情期间肺癌患者的诊治：是、非与未知
Mariangela Torniai,Veronica Agostinelli,Luca Cantini et al.
Mariangela Torniai et al.
Aim: During the coronavirus disease 2019 (COVID-19) pandemic two needs have overlapped: on one hand continuing to provide the best care for patients with lung cancer and preventing the spread of the virus between patients...
Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity [0.03%]
Bcl-2疏水裂隙和BH4结构域之间的别构相互作用调节IP3受体活性
George Shapovalov,Abigaël Ritaine,Nadege Charlene Essonghe et al.
George Shapovalov et al.
Aim: Inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitous calcium (Ca2+) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays a...
Myeloid cell leukemia-1: a formidable barrier to anticancer therapeutics and the quest of targeting it [0.03%]
髓系细胞白血病-1：抗癌治疗的严峻障碍及其靶向策略的研究任务
Prasad Sulkshane,Tanuja Teni
Prasad Sulkshane
The antiapoptotic B cell lymphoma-2 (Bcl-2) family members are apical regulators of the intrinsic pathway of apoptosis that orchestrate mitochondrial outer membrane permeabilization (MOMP) through interactions with their proapoptotic counte...
A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression [0.03%]
一种新颖的癌症治疗方法：理解痛觉TRP通道介导的Ca2+信号在调控癌症发展中的作用
Wen-Li Hsu,Mami Noda,Tohru Yoshioka et al.
Wen-Li Hsu et al.
Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, reactive oxygen species (ROS) accumulation, DNA damage r...
Padma-Sheela Jayaraman,Kevin Gaston
Padma-Sheela Jayaraman
Cholangiocarcinoma (CCA) is a disease with a very poor prognosis and limited treatment options. Although targeted therapies directed towards specific mutations found in CCA are becoming available and are showing great potential, many tumors...