Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma [0.03%]
多发性骨髓瘤的精准医疗多组学肿瘤检测技术
Sara Ovejero,Jerome Moreaux
Sara Ovejero
Multiple myeloma (MM), the second most common hematologic cancer, is caused by accumulation of aberrant plasma cells in the bone marrow. Its molecular causes are not fully understood and its great heterogeneity among patients complicates th...
Non-invasive detection of epithelial mesenchymal transition phenotype and metastatic dissemination of lung cancer by liquid biopsy [0.03%]
通过液体活检非侵入性检测肺癌上皮间质转化表型和转移播散
Viviana De Rosa,Rosa Fonti,Silvana Del Vecchio et al.
Viviana De Rosa et al.
The occurrence of phenotype switch from an epithelial to a mesenchymal cell state during the activation of the epithelial mesenchymal transition (EMT) program in cancer cells has been closely associated with the generation of invasive tumor...
Domenica Lorusso,Valentina Ceni,Gennaro Daniele et al.
Domenica Lorusso et al.
Immunotherapy has changed the natural history of several malignancies that, a decade ago, had a very poor prognosis, such as lung cancer and melanoma. Consequently, many attempts have been done to expand the indications of immunotherapy age...
Old but gold: the role of drug combinations in improving response to immune check-point inhibitors in thoracic malignancies beyond NSCLC [0.03%]
老药新用：药物联合使用可改善免疫检查点抑制剂治疗非小细胞肺癌之外的胸部恶性肿瘤的有效性及其机制分析
Luca Cantini,Federica Pecci,Filippo Merloni et al.
Luca Cantini et al.
The introduction of immune checkpoint inhibitors (ICIs) in non-oncogene addicted non-small cell lung cancer (NSCLC) has revolutionized the treatment scenario and led to a meaningful improvement in patient prognosis. Disappointingly, the suc...
Emerging role of pioneer transcription factors in targeted ERα positive breast cancer [0.03%]
先驱转录因子在雌激素受体α阳性乳腺癌中的作用不容小觑
Honey Pavithran,Ranjith Kumavath
Honey Pavithran
Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, "pioneer factors" are an emerging class of TFs that specifically in...
Aptamers and antibodies: rivals or allies in cancer targeted therapy? [0.03%]
适配体和抗体在癌症靶向治疗中的角色：竞争对手还是盟友？
Lisa Agnello,Simona Camorani,Monica Fedele et al.
Lisa Agnello et al.
The goal of an efficacious cancer therapy is to specifically target diseased cells at high accuracy while sparing normal, healthy cells. Over the past three decades, immunotherapy, based on the use of monoclonal antibodies (mAbs) directed a...
Implementation of an NGS panel for clinical practice in paraffin-embedded tissue samples from locally advanced and metastatic melanoma patients [0.03%]
一种NGS检测panel在局部晚期和转移性黑色素瘤石蜡样本中的临床应用实施
Paola Castillo,Marta Marginet,Pedro Jares et al.
Paola Castillo et al.
Aim: Single biomarker diagnostic test of BRAFV600 locus in metastatic melanoma is mandatory for treatment decision; however, multiple-gene based techniques, such as targeted next-generation sequencing (NGS) are being used...
Multiple adverse drug reactions during all-trans retinoic acid treatment for acute promyelocytic leukemia: differentiation syndrome, bradycardia, intestinal necrosis [0.03%]
全反式维甲酸治疗急性早幼粒细胞白血病的多种不良反应：分化综合征、心动过缓及肠坏死
Valeria Ferla,Mariarita Sciumé,Umberto Gianelli et al.
Valeria Ferla et al.
All-trans retinoic acid (ATRA) induces complete remission in a high proportion of acute promyelocytic leukemia (APL). Nevertheless it is be associated with adverse drug reactions that might be life-threatening including differentiation synd...
The impact of tumour pH on cancer progression: strategies for clinical intervention [0.03%]
肿瘤pH值对癌症进展的影响及临床干预策略
Carol Ward,James Meehan,Mark E Gray et al.
Carol Ward et al.
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through ...
Angiogenesis and epidermal growth factor receptor inhibitors in non-small cell lung cancer [0.03%]
非小细胞肺癌的血管生成及表皮生长因子受体抑制剂疗法
Giuliano Palumbo,Giovanna Esposito,Guido Carillio et al.
Giuliano Palumbo et al.
Several preclinical studies suggested a potential benefit from combined treatment with inhibitors of epidermal growth factor receptor (EGFR) and angiogenesis, both effective in patients with advanced non-small-cell lung cancer (NSCLC). In p...