Targeting HER2 in breast cancer: new drugs and paradigms on the horizon [0.03%]
乳腺癌中的HER2靶向治疗：新药和新模式的展望
Paolo Tarantino,Stefania Morganti,Giuseppe Curigliano
Paolo Tarantino
About 15-20% of all breast cancers (BCs) are defined human epidermal growth factor receptor 2 (HER2)-positive, based on the overexpression of HER2 protein and/or amplification of ERBB2 gene. Such alterations lead to a more aggressive behavi...
Annarita Perillo,Mohamed Vincenzo Agbaje Olufemi,Jacopo De Robbio et al.
Annarita Perillo et al.
Lung cancer is the most common cancer and the leading cause of cancer mortality worldwide. To date, tissue biopsy has been the gold standard for the diagnosis and the identification of specific molecular mutations, to guide choice of therap...
Nuclear factor erythroid 2-related factor 2 modulates HER4 receptor in ovarian cancer cells to influence their sensitivity to tyrosine kinase inhibitors [0.03%]
核因子红细胞生成素-2相关因子2通过调节卵巢癌细胞HER4受体的影响来影响其对酪氨酸激酶抑制剂的敏感性
Ibrahim H Kankia,Poornima Paramasivan,Matthew Elcombe et al.
Ibrahim H Kankia et al.
Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell's response to oxidative and electrophilic stress and is a transcription factor regulating the expression of a collection of anti-oxida...
Alana L Cutliffe,Sharon L McKenna,Darshan S Chandrashekar et al.
Alana L Cutliffe et al.
Aim: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor grade, nodal-metastatic stage, and p...
Interface between obesity with dysfunctional metabolism and inflammation, and the triple-negative breast cancer in African American women [0.03%]
肥胖代谢功能障碍与炎症和非裔美国女性三阴性乳腺癌之间的界面关系
Katarzyna Rygiel
Katarzyna Rygiel
Obesity has dramatically increased over the past fifty years. In the last decade, it has been noted that augmented body mass, metabolic abnormalities, and the relevant "obese" tumor microenvironment (TME) are connected with signaling molecu...
Immunotherapy in head and neck squamous cell carcinoma and rare head and neck malignancies [0.03%]
头颈部鳞状细胞癌和其他罕见头颈恶性肿瘤的免疫治疗
Stefano Cavalieri,Daria Maria Filippini,Arianna Ottini et al.
Stefano Cavalieri et al.
The dismal prognosis of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) prompted recent advances in the field of therapeutic approaches beyond cytotoxic cancer therapy. In recent years, the deeper and increasing kno...
Proteolysis-targeting chimeras and their implications in breast cancer [0.03%]
蛋白酶体靶向嵌合体及其在乳腺癌中的应用展望
Angeles C Tecalco-Cruz,Jesús Zepeda-Cervantes,Josué O Ramírez-Jarquín et al.
Angeles C Tecalco-Cruz et al.
Breast cancer (BC) is a highly heterogeneous neoplasm of the mammary tissue, causing the deaths of a large number of women worldwide. Nearly 70% and 20% of BC cases are estrogen receptor alpha positive (ERα+) and human epidermal growth fac...
Hao Xie,Junjia Liu,Diego M Alem Glison et al.
Hao Xie et al.
Proteolysis targeting chimeras (PROTACs) are a class of small molecules designed to target proteins for degradation. Their novel and unique modes of action provide PROTACs with the potential for their application in the management of both s...
The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type [0.03%]
BET降解剂MZ1在活化B细胞样弥漫性大B细胞淋巴瘤中表现出抗肿瘤作用
Chiara Tarantelli,Eleonora Cannas,Hillarie Ekeh et al.
Chiara Tarantelli et al.
Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical and early clinical evidence sustain BET targeting as an anti-cancer ap...
Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates [0.03%]
美登素衍生物与奥雷斯坦衍生抗肿瘤抗体偶联物的物理性质比较研究
Tomohiro Fujii,Calliste Reiling,Colette Quinn et al.
Tomohiro Fujii et al.
Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four dif...