Federica Miglietta,Maria Silvia Cona,Maria Vittoria Dieci et al.
Federica Miglietta et al.
Although breast cancer is not traditionally considered an immunogenic type of tumor, the combination of immunotherapy and chemotherapy has recently emerged as a novel treatment option in triple-negative subtype in the advanced setting and o...
Partha Mitra
Partha Mitra
Cancer drug discovery is currently dominated by clinical trials or clinical research. Several potential drug candidates have been brought into the pipeline of drug discovery after showing very promising results at the pre-clinical level and...
Antibody-drug conjugate therapies in multiple myeloma-what's next on the horizon? [0.03%]
抗体偶联物在多发性骨髓瘤治疗中的应用——前景如何？
Monique Hartley-Brown,Paul Richardson
Monique Hartley-Brown
Targeted immunotherapy has arisen over the past decade to the forefront of cancer care. Notably, targeted therapies such as antibody-drug conjugates (ADCs) are becoming more recognized for a novel approach in cancer treatment. The mechanism...
Liver venous deprivation for resection of advanced hilar cholangiocarcinoma-a case report and review of the literature [0.03%]
肝静脉隔离在无法切除的肝门部胆管癌中的应用-一例报告及文献回顾
Radoslava Stoyanova,Helmut Kopf,Wolfgang Schima et al.
Radoslava Stoyanova et al.
Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with...
New antibody-drug conjugates (ADCs) in breast cancer-an overview of ADCs recently approved and in later stages of development [0.03%]
乳腺癌领域的新抗体药物偶联物（ADC）——近期获批和后期开发阶段的ADC概览
Kira-Lee Koster,Jens Huober,Markus Joerger
Kira-Lee Koster
Antibody-drug conjugates (ADCs) have changed the treatment of breast cancer (BC) in more recent years. BC is a heterogenous group of malignancies with a broad range of histopathological characteristics. ADCs represent a class of therapeutic...
Targeting the two-pore channel 2 in cancer progression and metastasis [0.03%]
针对肿瘤进展和转移中的两孔通道蛋白2的靶向作用
Kathryn A Skelding,Daniel L Barry,Danielle Z Theron et al.
Kathryn A Skelding et al.
The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore cha...
Engineered phosphorus dendrimers as powerful non-viral nanoplatforms for gene delivery: a great hope for the future of cancer therapeutics [0.03%]
工程化磷树枝状分子作为有力的非病毒基因传递纳米平台：未来癌症治疗的新希望
Serge Mignani,Xiangyang Shi,Maria Bryszewska et al.
Serge Mignani et al.
During the past two decades, tremendous progress has been made in the dendrimer-based delivery of therapeutic molecules including, for instance, small molecules, macromolecules, and genes. This review deals with recent successes in the deve...
Bcl-2-like protein-10 increases aggressive features of melanoma cells [0.03%]
Bcl-2样蛋白-10增加黑色素瘤细胞的侵袭性特征
Donatella Del Bufalo,Marta Di Martile,Elisabetta Valentini et al.
Donatella Del Bufalo et al.
Aim: B-cell lymphoma-2 (Bcl-2)-like protein-10 (Bcl2L10) is the less studied member of Bcl-2 family proteins, with the controversial role in different cancer histotypes. Very recently, Bcl2L10 expression in melanoma tumor...
Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma [0.03%]
基因生物标志物在转移性结直肠癌患者临床管理中的作用
Anna Maria Rachiglio,Alessandra Sacco,Laura Forgione et al.
Anna Maria Rachiglio et al.
Colorectal carcinoma (CRC) is an heterogeneous disease in which different genetic alterations play a role in its pathogenesis and progression and offer potential for therapeutic intervention. The research on predictive biomarkers in metasta...
Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer [0.03%]
法尼科贫血途径抑制剂可能用于卵巢癌的抗肿瘤药物
Sarah J Taylor,Mark J Arends,Simon P Langdon
Sarah J Taylor
The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of ovarian and other cancers which rely exte...