Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer [0.03%]
评估法尼醇X受体拮抗剂吐根碱治疗癌症的潜在作用
Sosmitha Girisa,Dey Parama,Choudhary Harsha et al.
Sosmitha Girisa et al.
Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations ...
Lynch syndrome-associated lung cancer: pitfalls of an immunotherapy-based treatment strategy in an unusual tumor type [0.03%]
林奇综合征相关性肺癌：一种罕见肿瘤类型免疫治疗策略的陷阱
Elena Maccaroni,Edoardo Lenci,Veronica Agostinelli et al.
Elena Maccaroni et al.
Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline alterations in mismatch repair (MMR) genes leading to increased risk of colon cancer as well as other cancer types. Non-small cell lung cancer (NSCLC) is not a...
Tumor burden as possible biomarker of outcome in advanced NSCLC patients treated with immunotherapy: a single center, retrospective, real-world analysis [0.03%]
肿瘤负担有可能成为免疫治疗疗效的生物标志物：一项单中心回顾性真实世界分析-晚期NSCLC患者的疗效观察
Edoardo Lenci,Giulia Marcantognini,Valeria Cognigni et al.
Edoardo Lenci et al.
Aim: The role of tumor burden (TB) for patients with non-small cell lung cancer (NSCLC) receiving immunotherapy is still unknown. The aim of this analysis was to analyze the prognostic value of TB in a real-world sample o...
Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis [0.03%]
肺癌进展和骨转移性肺癌中的Ca2+信号通路综述
Manh Tien Tran
Manh Tien Tran
Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of fundamental cellular physiology such as gene expression, ce...
Clara Llorente-González,Marta González-Rodríguez,Miguel Vicente-Manzanares
Clara Llorente-González
Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide. Mutations and alteratio...
Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets [0.03%]
癌症转移和钙信号传导研究进展及治疗潜力
Chaochu Cui,Yongxi Zhang,Gang Liu et al.
Chaochu Cui et al.
Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell int...
Giuseppe Viscardi,Davide Di Natale,Morena Fasano et al.
Giuseppe Viscardi et al.
Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have not proven to be effective and also pathol...
Marta Brambilla,Giuseppe Lo Russo,Roberto Ferrara et al.
Marta Brambilla et al.
Hyperprogressive disease (HPD) is a novel pattern of response during immunotherapy treatment. Several retrospective studies have evaluated its prevalence among various cancer types and, in particular, in non-small cell lung cancer patients,...
Use of liquid biopsy in monitoring therapeutic resistance in EGFR oncogene addicted NSCLC [0.03%]
液体活检在EGFR原癌基因依赖型非小细胞肺癌治疗抵抗监测中的应用
Marialucia Iacovino,Vincenza Ciaramella,Fernando Paragliola et al.
Marialucia Iacovino et al.
Liquid biopsy has emerged as a minimally invasive alternative to tumor tissue analysis for the management of lung cancer patients, especially for epidermal growth factor receptor (EGFR) oncogene addicted tumor. In these patients, despite th...
Shanaya Ramchandani,Irum Naz,Namrata Dhudha et al.
Shanaya Ramchandani et al.
Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effects and high toxicities, leaving room for ...