Future directions and management of liquid biopsy in non-small cell lung cancer [0.03%]
液体活检在非小细胞肺癌中的应用展望与挑战
Alessia Maria Cossu,Marianna Scrima,Angela Lombardi et al.
Alessia Maria Cossu et al.
Lung cancer represents the world's most common cause of cancer death. In recent years, we moved from a generic therapeutic strategy to a personalized approach, based on the molecular characterization of the tumor. In this view, liquid biops...
Zi Wayne Sin,Vipul Bhardwaj,Amit Kumar Pandey et al.
Zi Wayne Sin et al.
Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that ...
The effect of iron on the expression levels of calcium related gene in cisplatin resistant epithelial ovarian cancer cells [0.03%]
铁对顺铂耐药的卵巢癌细胞中钙离子相关基因表达的影响研究
Bahire Kucukkaya,Demet Erdag,Fahri Akbas et al.
Bahire Kucukkaya et al.
Aim: Anticancer drugs (chemotherapeutics) used in cancer treatment (chemotherapy) lead to drug resistance. This study was conducted to investigate the possible effect of iron on calcium homeostasis in epithelial ovarian c...
The promising potential of piperlongumine as an emerging therapeutics for cancer [0.03%]
长角豆碱在癌症治疗中的前景及其作为新兴抗癌药物的潜力研究进展
Dey Parama,Varsha Rana,Sosmitha Girisa et al.
Dey Parama et al.
In spite of the immense advancement in the diagnostic and treatment modalities, cancer continues to be one of the leading causes of mortality across the globe, responsible for the death of around 10 million patients every year. The foremost...
Does the gut microbiome environment influence response to systemic breast cancer treatment? [0.03%]
肠道微生物环境是否会影响系统性乳腺癌治疗的反应？
Eilidh Bruce,Stanislau Makaranka,Gordon Urquhart et al.
Eilidh Bruce et al.
The gut microbiome is a novel player in the pathogenesis and treatment of breast cancer. The term "microbiome" is used to describe the diverse community of micro-organisms existing within the gastrointestinal tract. The gut microbiome plays...
The evolving role and utility of off-label drug use in multiple myeloma [0.03%]
免疫抑制剂类药物在多发性骨髓瘤中的超适应症使用及其效用和作用机制的演变
James H Stoeckle,Faith E Davies,Louis Williams et al.
James H Stoeckle et al.
The treatment landscape for multiple myeloma (MM) has dramatically changed over the last three decades, moving from no US Food and Drug Administration approvals and two active drug classes to over 19 drug approvals and at least eight differ...
Giulia Meoni,Nicola Libertà Decarli,Maurizio Benucci et al.
Giulia Meoni et al.
Immunotherapy dramatically changed the management of several malignancies including non-small cell lung cancer (NSCLC). Since immune checkpoint inhibitors have a different mechanism of action from cytotoxic agents or small molecules against...
Almaz Zagidullin,Vasili Milyukov,Albert Rizvanov et al.
Almaz Zagidullin et al.
Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together both the E3 enzyme and the target. These co...
Diagnostic and prognostic role of liquid biopsy in non-small cell lung cancer: evaluation of circulating biomarkers [0.03%]
液体活检在非小细胞肺癌诊断和预后中的作用：循环生物标志物的评估
Giovanni Vicidomini,Roberto Cascone,Annalisa Carlucci et al.
Giovanni Vicidomini et al.
Lung cancer is still one of the main causes of cancer-related death, together with prostate and colorectal cancers in males and breast and colorectal cancers in females. The prognosis for non-small cell lung cancer (NSCLC) is strictly depen...
Current strategies for the design of PROTAC linkers: a critical review [0.03%]
用于设计PROTAC连接器的当前策略：批判性评论
Robert I Troup,Charlene Fallan,Matthias G J Baud
Robert I Troup
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an "anchor" to bind to an E3 ubiquitin ligase and a "warhead" to bind to a protein of interest, connected by a chemical linker. Targeted pr...