Next-generation nanocarriers for precision antitumor therapy: from passive targeting to intelligent response [0.03%]
下一代智能抗肿瘤治疗纳米载药系统：从被动靶向到主动响应
Dilpreet Singh,Akshay Kumar
Dilpreet Singh
The evolution of nanocarrier-based drug delivery systems has transformed the paradigm of cancer therapeutics, advancing from conventional cytotoxic formulations to intelligent, adaptive nanosystems capable of precision targeting. Early-gene...
Emily Kay,Mahnaz Kazi,Jeremy Burton et al.
Emily Kay et al.
Immune checkpoint inhibitor (ICI) therapy has revolutionized metastatic melanoma treatment, yet only a subset of patients respond effectively, and the treatment can induce a variety of immune-related adverse events (irAEs), including coliti...
Conceptualization of fibroblast growth factor receptor 1 targeting nanomedicines [0.03%]
靶向成纤维细胞生长因子受体1的纳米药物的概念化
Yilin Ma,Mengqin Guo,Yang Liu et al.
Yilin Ma et al.
Fibroblast growth factor receptor 1 (FGFR1) is crucial in the progression of various cancers, participating in the processes of cell proliferation, survival, and differentiation. FGFR1 plays a role in the resistance to immune checkpoint inh...
Optimizing procedures for ocular radiation injury studies in the tree shrew [0.03%]
用于研究树鼩眼部放射损伤的优化方法
Lauren A Dalvin,Kjersten J Anderson,Tommy A Rinkoski et al.
Lauren A Dalvin et al.
Radiation exposure to the eye during cancer treatment can lead to ocular radiation injury (ORI), a devastating condition that can have a profound and permanent impact on vision-related quality of life. Rodent models do not have adequate ocu...
Unmasking the microbiome: the hidden role of gut bacteria in the pathogenesis of colorectal cancer and its prevention strategies [0.03%]
揭秘微生物组：肠道菌群在结直肠癌发病机制中的隐秘作用及其预防策略
Tallha W Khawaja,Lei Zhao,Raiq Siddiq et al.
Tallha W Khawaja et al.
Colorectal cancer (CRC) is a significant global health problem, ranking as the third most common cancer and the second leading cause of cancer deaths in the world. The highest incidence of CRC is found in developed regions, thus underlining...
Panagiotis J Vlachostergios
Panagiotis J Vlachostergios
Therapeutic cancer vaccines harness the adaptive immune system to eradicate malignancies by targeting tumor-specific antigens. This review charts the evolution of cancer vaccine platforms-from shared tumor-associated antigens (TAAs) and den...
Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer [0.03%]
微生物群在免疫检查点抑制癌症治疗中的作用
Ger T Rijkers,Yonah Langcauon,Pippe van Leersum et al.
Ger T Rijkers et al.
The realization that the composition and functionality of gut microbiota have an impact on the outcome of immune checkpoint inhibition (ICI) therapy of cancer has initiated research into the potential of microbiota management as adjunctive ...
Smart nanofluidic systems powered by DNA origami for targeted intracellular delivery: a newer approach [0.03%]
一种新的细胞内靶向递送方法：利用DNA折纸技术驱动的纳米流体系统
Dilpreet Singh,Satvir Singh,Nitin Tandon et al.
Dilpreet Singh et al.
The convergence of DNA nanotechnology with nanofluidics has catalyzed a transformative shift in precision drug delivery. DNA origami, a self-assembled nanoscale architecture constructed via programmable base pairing, offers atomically preci...
Metal grafted graphene-based nanomaterials towards cancer theranostic efficacy [0.03%]
金属修饰的石墨烯纳米材料用于癌症诊疗效果的研究
Prashant H Gohil,Gopal Avashthi
Prashant H Gohil
Cancer is one of the leading global causes of mortality and morbidity, so it needs early diagnosis and therapies. Traditional diagnostic and therapeutic strategies are inadequate due to several limitations, such as poor specificity, systemi...
Immune checkpoint inhibitor-induced hemophagocytic lymphohistiocytosis in lung cancer: a case series [0.03%]
免疫检查点抑制剂诱导的肺癌患者的噬血细胞综合征病例系列研究
Abdul Wali Khan,Simran Chandra,Himil Mahadevia et al.
Abdul Wali Khan et al.
Immune checkpoint inhibitors (ICIs) are established treatments for various malignancies, including lung, kidney, and colorectal cancers. However, their broad use has led to an increase in immune-related adverse events (irAEs), with thyroidi...