Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions [0.03%]
肿瘤相关成纤维细胞对抗肿瘤免疫反应的调节：机制及抑制其免疫抑制功能的策略
Jerome Thiery
Jerome Thiery
Cancer-associated fibroblasts (CAFs) are highly heterogeneous players that shape the tumor microenvironment and influence tumor progression, metastasis formation, and response to conventional therapies. During the past years, some CAFs subs...
Targeted RNA-sequencing analysis for fusion transcripts detection in tumor diagnostics: assessment of bioinformatic tools reliability in FFPE samples [0.03%]
用于肿瘤诊断中融合转录本检测的目标RNA序列分析：评估在FFPE样本中生物信息工具的可靠性
Iolanda Capone,Fabio Bozzi,Gian Paolo Dagrada et al.
Iolanda Capone et al.
Aim: Diagnostic laboratories are progressively introducing next-generation sequencing (NGS) technologies in the routine workflow to meet the increasing clinical need for comprehensive molecular characterization in cancer ...
A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options [0.03%]
肿瘤相关性铁死亡中的xCT角色为新型治疗方法提供了思路
Daniela Criscuolo,Francesco Morra,Angela Celetti
Daniela Criscuolo
Solute carrier family 7 member 11 (SLC7A11; also known as xCT), a key component of the cystine/glutamate antiporter, is essential for the maintenance of cellular redox status and the regulation of tumor-associated ferroptosis. Accumulating ...
The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors [0.03%]
前列腺癌的肿瘤固有免疫微环境：可溶因素和细胞效应物概览
Maria Teresa Palano,Matteo Gallazzi,Martina Cucchiara et al.
Maria Teresa Palano et al.
Prostate cancer (PCa) accounts as the most common non-cutaneous disease affecting males, and as the first cancer, for incidence, in male. With the introduction of the concept of immunoscore, PCa has been classified as a cold tumor, thus dri...
N6-methyladenosine-related microRNAs risk model trumps the isocitrate dehydrogenase mutation status as a predictive biomarker for the prognosis and immunotherapy in lower grade gliomas [0.03%]
N6-甲基腺苷相关性微小RNA风险模型在低级别胶质瘤预后和免疫治疗中的预测标志物方面优于异柠檬酸脱氢酶突变状态
Feng Yuan,Yingshuai Wang,Xiangming Cai et al.
Feng Yuan et al.
Aim: Lower grade gliomas [LGGs; World Health Organization (WHO) grades 2 and 3], owing to the heterogeneity of their clinical behavior, present a therapeutic challenge to neurosurgeons. The aim of this study was to explor...
Myeloid-derived suppressor cells in colorectal cancer: prognostic biomarkers and therapeutic targets [0.03%]
髓源性抑制细胞在结直肠癌中的预后价值及治疗意义
Mohammad A Al-Mterin,Eyad Elkord
Mohammad A Al-Mterin
Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid cells, which are expanded in most cancer patients. MDSCs suppress host immune responses, leading to cancer growth and progression. Several studies demonstrated that th...
Clinical applications of liquid biopsy in HPV-negative and HPV-positive head and neck squamous cell carcinoma: advances and challenges [0.03%]
液态活检在HPV阴性和HPV阳性头颈鳞癌的临床应用：进展与挑战
Mariana Chantre-Justino,Gilda Alves,Lucas Delmonico
Mariana Chantre-Justino
Head and neck squamous cell carcinomas (HNSCCs) represent the most common epithelial tumors that arise from mucosa of the oral cavity, pharynx, and larynx. The development of HNSCCs is usually associated with tobacco use, alcohol consumptio...
Tianying Xie,Sitong Chen,Jiang Hao et al.
Tianying Xie et al.
Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal c...
David Musheyev,Anya Alayev
David Musheyev
Endocrine resistance is a major hurdle in the treatment of estrogen receptor (ER)-positive breast cancer. When abnormally regulated, molecular signals responsible for cellular proliferation, as well as ER itself, allow for cellular evasion ...
Huapan Fang,Qian Chen
Huapan Fang
With the rapid development of gene therapy technology and the outbreak of coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) therapeutics have attracted more and more attention, and the COVID-19 mRNA vaccine has been approved by the ...