Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity [0.03%]
MET、PD-1/PD-L1和mTOR通路在肾细胞癌原发灶及肺转移灶中的免疫表型回顾性分析：RIVELATOR研究揭示生物标志物异质性问题
Melissa Bersanelli,Letizia Gnetti,Francesco Paolo Pilato et al.
Melissa Bersanelli et al.
Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistance. This study aimed to as...
Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer [0.03%]
aspirin和癌症代谢标志：治疗结直肠癌的新机遇
Ashley J Hoskin,Amy K Holt,Danny N Legge et al.
Ashley J Hoskin et al.
Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as an adjuvant for cancer treatment. Importantly there has been an increasing number ...
Nanomedicine strategies to counteract cancer stemness and chemoresistance [0.03%]
用于抑制癌症干细胞属性和化学抗性的纳米医学策略
Huayu Liu,Mingqi Liu,Yanan Zhao et al.
Huayu Liu et al.
Cancer stem-like cells (CSCs) identified by self-renewal ability and tumor-initiating potential are responsible for tumor recurrence and metastasis in many cancers. Conventional chemotherapy fails to eradicate CSCs that hold a state of dorm...
Benjamin Atwell,Pavani Chalasani,Joyce Schroeder
Benjamin Atwell
Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance. This intense study has led to the development of a range of targeted therapeutics...
Current role of machine learning and radiogenomics in precision neuro-oncology [0.03%]
精准神经肿瘤学中机器学习和影像基因组学的当前作用
Teresa Perillo,Marco de Giorgi,Umberto Maria Papace et al.
Teresa Perillo et al.
In the past few years, artificial intelligence (AI) has been increasingly used to create tools that can enhance workflow in medicine. In particular, neuro-oncology has benefited from the use of AI and especially machine learning (ML) and ra...
Anticancer action of naturally occurring emodin for the controlling of cervical cancer [0.03%]
天然产物大黄酚的抗宫颈癌作用研究
Priyanka S Lande,Vaibhav S Adhao,Jaya P Ambhore et al.
Priyanka S Lande et al.
One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notab...
Artificial intelligence ethics in precision oncology: balancing advancements in technology with patient privacy and autonomy [0.03%]
精准肿瘤学中的人工智能伦理：在技术进步与患者隐私和自主权之间取得平衡
Bahareh Farasati Far
Bahareh Farasati Far
Precision oncology is a rapidly evolving field that uses advanced technologies to deliver personalized cancer care based on a patient's unique genetic and clinical profile. The use of artificial intelligence (AI) in precision oncology has s...
Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma [0.03%]
特定肠道菌群治疗不可切除肝细胞癌的潜在策略
Sayuri Yoshikawa,Kurumi Taniguchi,Haruka Sawamura et al.
Sayuri Yoshikawa et al.
Hepatocellular carcinoma (HCC) constitutes an extremely malignant form of primary liver cancer. Intricate connections linking to the immune system might be associated with the pathogenesis of HCC. Meanwhile, immunotherapy with immune checkp...
B-cell lymphoma 2 family members and sarcomas: a promising target in a heterogeneous disease [0.03%]
B细胞淋巴瘤2家族成员与软组织肉瘤：一种异质性疾病中的潜在治疗靶点
Rui Caetano Oliveira,João Gama,José Casanova
Rui Caetano Oliveira
Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements. The Bcl-2 family is a major player in apoptosis regulation and, has captured the researcher's i...
Medicinal chemistry advances in targeting class I histone deacetylases [0.03%]
表观遗传药物研发中组蛋白脱乙酰酶I类异构酶抑制剂的研究进展
Diaaeldin I Abdallah,Elvin D de Araujo,Naman H Patel et al.
Diaaeldin I Abdallah et al.
Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight ...