Facing the conundrum: which first-line therapy should be used for patients with metastatic triple-negative breast cancer carrying germline BRCA mutation? [0.03%]
面对困境：应采用哪种一线治疗用于携带种系BRCA突变的转移性三阴性乳腺癌患者？
Sabah Alaklabi,Arya Mariam Roy,Lubna N Chaudhary et al.
Sabah Alaklabi et al.
Pembrolizumab combined with chemotherapy has been established as the preferred first-line therapy for treating metastatic triple-negative breast cancer (mTNBC) with programmed cell death ligand-1 (PD-L1)-positive disease since its approval ...
Receptor tyrosine kinase-like orphan receptor 1 inhibitor strictinin exhibits anti-cancer properties against highly aggressive androgen-independent prostate cancer [0.03%]
受体酪氨酸激酶样孤儿受体1抑制剂strictinin对高度侵袭性的雄激素非依赖性前列腺癌具有抗肿瘤作用
Vignesh Sivaganesh,Bela Peethambaran
Vignesh Sivaganesh
Aim: It is important to identify anti-cancer compounds that can inhibit specific molecular targets to eradicate androgen-receptor negative (ARneg), androgen-independent (AI) prostate cancer, which is an aggressive form of...
Cola rostrata K. Schum. constituents induce cytotoxicity through reactive oxygen species generation and mitochondrial membrane depolarisation [0.03%]
可引致反应性氧物种产生及线粒体膜去极化的Cola rostrata K. Schum.成分具细胞毒性效应
Babatunde E Ajayi,Bola Oboh,Joseph B Minari et al.
Babatunde E Ajayi et al.
Aim: While the traditional use of Cola rostrata in treating illnesses and diseases has not been reported, the presence of cytotoxic principles has been reported in phylogenetically and biogeographically related species wi...
Current implications and challenges of artificial intelligence technologies in therapeutic intervention of colorectal cancer [0.03%]
人工智能技术在结肠癌治疗干预中的现行意义与挑战
Kriti Das,Maanvi Paltani,Pankaj Kumar Tripathi et al.
Kriti Das et al.
Irrespective of men and women, colorectal cancer (CRC), is the third most common cancer in the population with more than 1.85 million cases annually. Fewer than 20% of patients only survive beyond five years from diagnosis. CRC is a highly ...
Therapeutic significance of tumor microenvironment in cholangiocarcinoma: focus on tumor-infiltrating T lymphocytes [0.03%]
胆管癌治疗意义中的肿瘤微环境：关注肿瘤浸润T淋巴细胞
Chaoqun Li,Lei Bie,Muhua Chen et al.
Chaoqun Li et al.
Cholangiocarcinoma (CCA) is a highly aggressive type of adenocarcinoma distinguished by its invasiveness. Depending on specific anatomical positioning within the biliary tree, CCA can be categorized into intrahepatic CCA (ICCA), perihilar C...
Telehealth in breast cancer following the coronavirus disease 2019 pandemic [0.03%]
新型冠状病毒肺炎疫情后的乳腺癌远程医疗
Jean Zeghondy,Elie Rassy,Pietro Lapidari et al.
Jean Zeghondy et al.
Breast cancer (BC) is the second most diagnosed cancer in 2018 with around 2.3 million cases globally in 2020. In March 2020 and after its worldwide spread, the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19...
Zhengwang Guo,Shuyan Han
Zhengwang Guo
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Cancer stem cells (CSCs) are thought to play a crucial role in TNBC progression and resistance to therapy. CSCs are a small su...
Post-translational modulation of cell signalling through protein succinylation [0.03%]
通过蛋白质丁酰化对细胞信号转导的翻译后调节
Katharina F Kubatzky,Yue Gao,Dayoung Yu
Katharina F Kubatzky
Cells need to adapt their activities to extra- and intracellular signalling cues. To translate a received extracellular signal, cells have specific receptors that transmit the signal to downstream proteins so that it can reach the nucleus t...
Impact of coronavirus disease 2019 pandemic on good clinical practice trials in oncology [0.03%]
新冠肺炎疫情对肿瘤学良好临床规范试验的影响
Veronica Agostinelli,Zelmira Ballatore,Giulia Ricci et al.
Veronica Agostinelli et al.
Aim: Coronavirus disease 2019 (COVID-19) became pandemic on 11th March 2020 and it deeply stressed the healthcare system. Cancer patients represent a vulnerable population, so many recommendations have been approved to en...
Youjun Li,Michael Karin,Edward V Prochownik
Youjun Li
Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53's product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the ...