Evgeny N Imyanitov,Elena V Preobrazhenskaya,Sergey V Orlov
Evgeny N Imyanitov
The management of lung cancer (LC) requires the analysis of a diverse spectrum of molecular targets, including kinase activating mutations in EGFR, ERBB2 (HER2), BRAF and MET oncogenes, KRAS G12C substitutions, and ALK, ROS1, RET and NTRK1-...
Giulia Pretelli,Kleida Mati,Lucia Motta et al.
Giulia Pretelli et al.
Antibody-drug conjugates (ADCs) have emerged as a promising class of anticancer agents. Currently, the Food and Drug Administration has granted approval to 12 compounds, with 2 later undergoing withdrawal. Moreover, several other compounds ...
Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity? [0.03%]
错配修复缺陷/微卫星不稳定型结直肠癌患者免疫检查点抑制剂治疗失败：误诊、假性进展还是肿瘤异质性？
Nicola Normanno,Vincenza Caridi,Matteo Fassan et al.
Nicola Normanno et al.
Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells in the tumor microenvironment. In agreemen...
Evaluation of antitumor potential of an anti-glypican-1 monoclonal antibody in preclinical lung cancer models reveals a distinct mechanism of action [0.03%]
评估抗glypican-1单克隆抗体在肺癌临床前模型中的抗肿瘤潜力并揭示其独特的作用机制
Minghua Li,Yanhong Wang,Xiaoyang Lin et al.
Minghua Li et al.
Aim: The main objective of this study was to investigate the antitumor effect of a mouse anti-human glypican-1 (GPC1) monoclonal antibody (mAb) on non-small cell lung carcinoma (NSCLC) and associated molecular mechanisms....
Practical implications of androgen receptor inhibitors for prostate cancer treatment [0.03%]
雄激素受体抑制剂用于前列腺癌治疗的实用意义
Fabio Campodonico,Luca Foppiani,Vittoria Campodonico et al.
Fabio Campodonico et al.
Antiandrogens have been used for the treatment of prostate cancer as a single agent or in combination with hormone deprivation therapy. New generation antiandrogens act like androgen receptor inhibitors (ARIs). Their binding complex blocks ...
Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis [0.03%]
抗PD-1/L1抗体联合抗VEGF抗体对比联合VEGFR靶向TKI作为不可切除肝细胞癌一线治疗的网状Meta分析
Yiwen Zhou,Jingjing Li,Jieer Ying
Yiwen Zhou
Background: This article is based on our previous research, which was presented at the 2023 ASCO Annual Meeting I and published in Journal of Clinical Oncology as Conference Abstract (JCO. 2023;41:e16148. doi: 10.1200/JCO...
Response to trametinib, hydroxychloroquine, and bevacizumab in a young woman with NRAS-mutated metastatic intrahepatic cholangiocarcinoma: a case report [0.03%]
携带NRAS突变的肝内胆管癌年轻女性患者接受曲马替尼、羟氯喹和贝伐珠单抗治疗后的疗效：一例病例报告
Aram A Musaelyan,Ekaterina M Anokhina,Alina I Turdubaeva et al.
Aram A Musaelyan et al.
Systemic chemotherapy is the main treatment option for patients with advanced intrahepatic cholangiocarcinoma (iCCA), however, its efficacy is limited. Herein, we report a young patient with NRAS-mutated chemoresistant metastatic iCCA, who ...
Improving the quality of patient care in lung cancer: key factors for successful multidisciplinary team working [0.03%]
提高肺癌患者护理质量：成功开展多学科团队合作的关键因素
Alessandro Morabito,Edoardo Mercadante,Paolo Muto et al.
Alessandro Morabito et al.
International Guidelines as well as Cancer Associations recommend a multidisciplinary approach to lung cancer care. A multidisciplinary team (MDT) can significantly improve treatment decision-making and patient coordination by putting diffe...
Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications [0.03%]
靶向信号转导衔接蛋白-2在癌症治疗中的潜在作用
Taiga Maemoto,Yuto Sasaki,Fumiya Okuyama et al.
Taiga Maemoto et al.
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YX...
Cancer symptom cluster research in pediatric oncology: a work in progress [0.03%]
儿科肿瘤学中的癌症症状群研究：正在进行中
Luciana Chain Veronez,Luís Carlos Lopes-Júnior
Luciana Chain Veronez
In the 21st century, advances in basic research have provided new insights in the field of pediatric oncology. Pediatric patients tend to experience higher levels of distressing symptoms, which together form a symptom cluster. In clinical p...