Assessment of lipid peroxidation and total antioxidant capacity in patients with breast cancer [0.03%]
乳腺癌患者脂质过氧化和总抗氧化能力的评估
Abdullatif Taha Babakr,Mohamed Mahmoud Nour Eldein
Abdullatif Taha Babakr
Aim: Breast cancer (BC), a disease in which abnormal breast cells grow out of control and form tumors, is a prevalent life-threatening disease worldwide. Oxidative stress has been implicated in the development and progres...
Targeted therapies and molecular targets in the therapeutic landscape of advanced urothelial carcinoma: state of the art and future perspectives [0.03%]
晚期尿路上皮癌治疗领域的靶向疗法和分子靶点：现状与未来展望
Irene Testi,Giulia Claire Giudice,Giuseppe Salfi et al.
Irene Testi et al.
Advanced urothelial carcinoma (aUC) has a dismal prognosis, with a 5-year survival rate of approximately 10%. Platinum-based chemotherapy has been the backbone of the first-line treatment of aUC for over 40 years. Only in the last decade, t...
Curative immunotherapy-based strategies for non-metastatic non-small cell lung cancer [0.03%]
非小细胞肺癌的治愈性免疫治疗策略
Justin J Kuhlman,Shenduo Li,Rami Manochakian et al.
Justin J Kuhlman et al.
The emergence of immunotherapy has ushered in a new era in the management of non-small cell lung cancer (NSCLC). Various immune check point inhibitors have demonstrated significant benefit in the management of locally advanced NSCLC that ar...
Predictive and prognostic biomarkers in cancer: towards the precision medicine era [0.03%]
癌症的预测和预后生物标志物：迈向精准医学时代
Stefano Marletta,Antonio Rizzo,Graziana Spoto et al.
Stefano Marletta et al.
Mansurah A Abdulazeez,Hiba A Jasim,Temidayo D Popoola et al.
Mansurah A Abdulazeez et al.
Despite the fact that life expectancies are increasing and the burden of infectious diseases is decreasing, global cancer incidence rates are on the rise. Cancer outcome metrics are dismal for low- and middle-income countries (LMICs), inclu...
Analysis of the benefit of anti-PD-1 monotherapy according to NGS-diagnosed genetic alterations in patients with non-small cell lung cancer [0.03%]
基于NGS诊断的基因变异分析免化疗晚期非小细胞肺癌患者使用纳武单抗治疗的疗效及安全性
Hortense De Saint Basile,Reza Elaidi,Zineb Maaradji et al.
Hortense De Saint Basile et al.
Aim: Immune checkpoint inhibitors improved the survival of advanced non-small cell lung cancer. However, only 20% of patients respond to these treatments and the search for predictive biomarkers of response is still topic...
The promises and perils of circulating tumor DNA for monitoring immunotherapy response in non-small cell lung cancer [0.03%]
循环肿瘤DNA在非小细胞肺癌免疫治疗反应监测中的利弊分析
Brandon Joseph Hebert,James Bradley
Brandon Joseph Hebert
There has been a rapid expansion of immunotherapy options for non-small cell lung cancer (NSCLC) over the past two decades, particularly with the advent of immune checkpoint inhibitors. Despite the emerging role of immunotherapy in adjuvant...
Addressing the unmet need in NSCLC progression with advances in second-line therapeutics [0.03%]
二线治疗新进展助力非小细胞肺癌患者满足治疗需求
Kinsley Wang,Alexis Leyba,Robert Hsu
Kinsley Wang
Lung cancer is the leading cause of cancer mortality globally, with non-small cell lung cancer (NSCLC) accounting for 85% of cases. Despite advancements in first-line treatments such as immunotherapy and targeted therapies, resistance to th...
Preliminary evaluation of FAPI-04-PET/CT for differentiating recurrence and post-treatment changes in high-grade gliomas [0.03%]
FAPI-04正电子发射断层扫描/计算机断层扫描鉴别高度恶性胶质瘤复发与治疗后改变的初步研究
Indraja D Dev,Ameya D Puranik,Venkatesh Rangarajan et al.
Indraja D Dev et al.
Fibroblast-activated protein (FAP) expression in glial cells is attributed to FAP-positive foci on tumor vessels and neoplastic cells. Preclinical and pilot studies have shown FAP expression in high-grade gliomas. We aimed at comparing PET ...
Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy [0.03%]
前列腺健康指数密度用于MRI-US融合靶向活检的诊断价值分析
Benjamin H Press,Soum D Lokeshwar,Lindsey Webb et al.
Benjamin H Press et al.
Aim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and PHI density (PHID) has bee...