Lova Prasadareddy Kajuluri,Kuldeep Singh,Kathleen G Morgan
Lova Prasadareddy Kajuluri
Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell...
Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care [0.03%]
概念验证：经导管主动脉瓣置换术前的数字钟绘图行为可能预测住院时间和护理成本
Margaret Ellenora Wiggins,Catherine Dion,Erin Formanski et al.
Margaret Ellenora Wiggins et al.
Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variabl...
Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes [0.03%]
基因组范围的关联研究发现新风险基因：这些基因控制着从第一次可卡因或阿片类药物使用到产生依赖症状的速度
Richard Sherva,Congcong Zhu,Leah Wetherill et al.
Richard Sherva et al.
Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability,...
Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study [0.03%]
胎盘OPRM1的DNA甲基化与新生儿阿片类药物戒断综合征的关系：一项初步研究
Elisha M Wachman,Alice Wang,Breanna C Isley et al.
Elisha M Wachman et al.
Aims: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonatal opioid withdrawal sy...
Honghuang Lin,Cody Karjadi,Ting F A Ang et al.
Honghuang Lin et al.
Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that ...
Identifying factors associated with opioid cessation in a biracial sample using machine learning [0.03%]
基于机器学习的识别二元种族样本中与阿片类药物戒断相关的因素
Jiayi W Cox,Richard M Sherva,Kathryn L Lunetta et al.
Jiayi W Cox et al.
Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. ...
Zhenying Han,Sonali Shaligram,Marie E Faughnan et al.
Zhenying Han et al.
Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell surface and oxidative stre...
Marvin Ryou,Nicholas Stylopoulos,Gyorgy Baffy
Marvin Ryou
Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from portal hyperte...
Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions [0.03%]
早产儿视网膜病变预防的现有证据和结果：关于新型母体和胎盘贡献的见解
Lara Carroll,Leah A Owen
Lara Carroll
Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild disease ma...