AI-driven drug discovery and repurposing using multi-omics for myocardial infarction and heart failure [0.03%]
基于多组学的AI驱动的心肌梗死和心力衰竭药物发现与老药新用
Ziad Sabry,Harkirat Singh Arora,Sriram Chandrasekaran et al.
Ziad Sabry et al.
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. Yet, drug discovery for these conditions faces significant challenges due to the complexity and heterogeneity of their underlying pathology. Recentl...
Solid tumor rejection using personalized incompatible human leukocyte antigen (HLA) and blood group ABH antigens [0.03%]
利用个性化不相容的人类白细胞抗原和ABH血型抗原排斥固体肿瘤
Apostolos P Georgopoulos,Lisa M James
Apostolos P Georgopoulos
Cancer immunotherapies have become mainstream, targeting tumor elimination via various mechanisms, albeit with varied effectiveness. Here, we review briefly the current landscape of cancer immunotherapies and the central role of human leuko...
Adherence timescale impacts completion rates of high-frequency mobile cognitive assessments among older adults [0.03%]
依从性时间尺度影响老年人高频移动认知评估的完成率
Kieffer Christianson,Meha Prabhu,Zachary T Popp et al.
Kieffer Christianson et al.
Aim: Mobile technology enables frequent, remote cognitive assessments, introducing new methodological opportunities and challenges. The study evaluated the feasibility of a high-frequency cognitive assessment schedule amo...
Anna Antipov,Nikolai Petrovsky
Anna Antipov
Vaccines are typically designed either for human or veterinary use. Using One Health principles it would be more efficient to develop a single vaccine to cover all animal and human species at threat from a specific pathogen. A major issue f...
The influence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) family history on patients with ME/CFS [0.03%]
家人患有肌痛性脑脊髓炎/慢性疲劳综合症（ME/CFS）对患者自身的影响研究
Leonard A Jason,Sarah Ngonmedje
Leonard A Jason
Aim: It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history. To explore this issue, quantita...
The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer's disease in the Framingham Heart Study [0.03%]
弗明翰心血管病研究中循环CD34+CD133+内皮前体细胞与阿尔茨海默病发病风险降低相关性研究
Yixuan Wang,Jinghan Huang,Ting Fang Alvin Ang et al.
Yixuan Wang et al.
Aim: Endothelial dysfunction has been associated with both cerebrovascular pathology and Alzheimer's disease (AD). However, the connection between circulating endothelial cells and the risk of AD remains uncertain. The ob...
Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia [0.03%]
子痫前期患者蜕膜CD4+t细胞导致妊娠大鼠抗血管紧张素Ⅱ受体自身抗体产生及高血压模型的研究
Kristin E Reeve,Evangeline Deer,Lorena M Amaral et al.
Kristin E Reeve et al.
Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously shown that CD4+ T cells isolated from women with PE cause hyp...
Digital sleep measures and white matter health in the Framingham Heart Study [0.03%]
弗明汉心脏研究中的数字睡眠测量与白质健康状况
Robert Joseph Thomas,Hyun Kim,Pauline Maillard et al.
Robert Joseph Thomas et al.
Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. ...
Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort [0.03%]
弗雷明汉认知衰老队列中语音认知障碍标志物的神经心理学测试验证
Larry Zhang,Anthony Ngo,Jason A Thomas et al.
Larry Zhang et al.
Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative speech to identify dem...
AS1411-functionalized delivery nanosystems for targeted cancer therapy [0.03%]
用于癌症靶向治疗的AS1411功能化传输纳米系统
Pooria Safarzadeh Kozani,Pouya Safarzadeh Kozani,Mohammad Tariq Malik
Pooria Safarzadeh Kozani
Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological ...