Structure and Role of a Ga-Promoter in Ni-Based Catalysts for the Selective Hydrogenation of CO2 to Methanol [0.03%]
Ni基催化剂中Ga助剂的结构及在CO2选择加氢制甲醇中的作用
Nora K Zimmerli,Lukas Rochlitz,Stefano Checchia et al.
Nora K Zimmerli et al.
Supported, bimetallic catalysts have shown great promise for the selective hydrogenation of CO2 to methanol. In this study, we decipher the catalytically active structure of Ni-Ga-based catalysts. To this end, model Ni-Ga-based catalysts, w...
Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations [0.03%]
Tau蛋白的突变通过促进扩展构象来促进聚集
Kevin Pounot,Clara Piersson,Andrew K Goring et al.
Kevin Pounot et al.
Amyloid aggregation of the intrinsically disordered protein (IDP) tau is involved in several diseases, called tauopathies. Some tauopathies can be inherited due to mutations in the gene encoding tau, which might favor the formation of tau a...
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses [0.03%]
基于结构指导的可预测响应的MUC1-糖肽癌症疫苗开发方法
Iris A Bermejo,Ana Guerreiro,Ander Eguskiza et al.
Iris A Bermejo et al.
Mucin-1 (MUC1) glycopeptides are exceptional candidates for potential cancer vaccines. However, their autoantigenic nature often results in a weak immune response. To overcome this drawback, we carefully engineered synthetic antigens with p...
Construction of an Enzyme Cascade Based on the Accurate Adjacent Arrangement of Coupled Enzymes Using a Triblock PolyA DNA Probe [0.03%]
利用三嵌段聚A DNA探针精确排列偶联酶构建级联系统的研究
Lele Wang,Ruiyan Guo,Lanying Li et al.
Lele Wang et al.
Intracellular enzyme cascades are essential for various biological processes, and mimicking their functions in artificial systems has attracted significant research attention. However, achieving convenient and efficient spatial organization...
Reshaping the Landscape of the Genome: Toolkits for Precise DNA Methylation Manipulation and Beyond [0.03%]
重塑基因组的景观：精确DNA甲基化操控工具包及展望
Chenyou Zhu,Ziyang Hao,Dongsheng Liu
Chenyou Zhu
DNA methylation plays a pivotal role in various biological processes and is highly related to multiple diseases. The exact functions of DNA methylation are still puzzling due to its uneven distribution, dynamic conversion, and complex inter...
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade [0.03%]
早发性帕金森突变重塑单体-纤维相互作用，从而放大α-突触核蛋白的淀粉样级联反应
Jinfeng Huang,Rashik Ahmed,Madoka Akimoto et al.
Jinfeng Huang et al.
Alpha synuclein (αS) aggregates are the main component of Lewy bodies (LBs) associated with Parkinson's disease (PD). A longstanding question about αS and PD pertains to the autosomal dominant E46K αS mutant, which leads to the early ons...
Direct Observation of In-Focus Plasmonic Cargos via Breaking Angular Degeneracy in Differential Interference Contrast Microscopy [0.03%]
通过差分干涉对比显微镜中的破角退化直接观察聚焦的等离子体货物
Geun Wan Kim,Ji Won Ha
Geun Wan Kim
Breaking the angular degeneracy arising from the 2-fold optical symmetry of plasmonic anisotropic nanoprobes is critical in biological studies. In this study, we propose differential interference contrast (DIC) microscopy-based focused orie...
Kinetics of H· Transfer from CpCr(CO)3H to Various Enamides: Application to Construction of Pyrrolidines [0.03%]
CpCr(CO)3H向各种烯胺转移氢原子的反应动力学研究：应用于吡咯里定的构建
Guangchen Li,Shicheng Shi,Jin Qian et al.
Guangchen Li et al.
The rate constants kH (kD) have been determined at 27 °C for H· (D·) transfer from CpCr(CO)3H(D) to the C=C bonds of various enamides. This process leads to the formation of α-amino radicals. Vinyl enamides with N-alkyl and N-phenyl sub...
SynCluster: Reaction Type Clustering and Recommendation Framework for Synthesis Planning [0.03%]
SynCluster：用于合成规划的反应类型聚类和推荐框架
Tiantao Liu,Zheng Cao,Yuansheng Huang et al.
Tiantao Liu et al.
AI-assisted synthesis planning has emerged as a valuable tool in accelerating synthetic chemistry for the discovery of new drugs and materials. The template-free approach, which showcases superior generalization capabilities, is seen as the...
Post-Treatment-Free Dual-Interface Passivation via Facile 1D/3D Perovskite Heterojunction Construction [0.03%]
通过简单的1D/3D钙钛矿异质结构建实现治疗后双重界面钝化
Ning Wei,Yanfeng Miao,Xingtao Wang et al.
Ning Wei et al.
For achieving high-efficiency perovskite solar cells, it is almost always necessary to substantially passivate defects and protect the perovskite structure at its interfaces with charge transport layers. Such a modification generally involv...