Copper(II) Can Kinetically Trap Arctic and Italian Amyloid-β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid-β42: Implications for Familial Alzheimer's Disease [0.03%]
铜(II)可以将北极型和意大利型淀粉样蛋白-β40动力学陷阱作为有毒寡聚体，模仿Cu(II)与野生型淀粉样蛋白-β42的结合：对家族性阿尔茨海默病的影响
Yao Tian,Qi Shang,Ruina Liang et al.
Yao Tian et al.
The self-association of amyloid-β (Aβ) peptide into neurotoxic oligomers is believed to be central to Alzheimer's disease (AD). Copper is known to impact Aβ assembly, while disrupted copper homeostasis impacts phenotype in Alzheimer's mo...
Exploring the Landscape of Aptamers: From Cross-Reactive to Selective to Specific, High-Affinity Receptors for Cocaine [0.03%]
探索适配体的领域：从交叉反应到选择性再到特异性、高亲和力的可卡因受体
Kyungae Yang,Obtin Alkhamis,Juan Canoura et al.
Kyungae Yang et al.
We reported over 20 years ago MNS-4.1, the first DNA aptamer with a micromolar affinity for cocaine. MNS-4.1 is based on a structural motif that is very common in any random pool of oligonucleotides, and it is actually a nonspecific hydroph...
Reprogramming the Transition States to Enhance C-N Cleavage Efficiency of Rhodococcus opacus l-Amino Acid Oxidase [0.03%]
通过改变过渡态提高土壤芽孢杆菌l-氨基酸氧化酶的C-N键断裂效率
Yaoyun Wu,Yaozhong Cui,Wei Song et al.
Yaoyun Wu et al.
l-Amino acid oxidase (LAAO) is an important biocatalyst used for synthesizing α-keto acids. LAAO from Rhodococcus opacus (RoLAAO) has a broad substrate spectrum; however, its low total turnover number limits its industrial use. To overcome...
Engineering Substrate Promiscuity of Nucleoside Phosphorylase Via an Insertions-Deletions Strategy [0.03%]
通过插入和删除策略改造核苷磷酸酶底物杂泛性
Gaofei Liu,Jialing Wang,Jianlin Chu et al.
Gaofei Liu et al.
Nucleoside phosphorylases (NPs) are the key enzymes in the nucleoside metabolism pathway and are widely employed for the synthesis of nucleoside analogs, which are difficult to access via conventional synthetic methods. NPs are generally cl...
Surface Structure to Tailor the Electrochemical Behavior of Mixed-Valence Copper Sulfides during Water Electrolysis [0.03%]
水解过程中混合价态铜硫化物电化学行为的表面结构调节
Avinava Kundu,Biswarup Chakraborty
Avinava Kundu
The semiconducting behavior of mixed-valence copper sulfides arises from the pronounced covalency of Cu-S bonds and the exchange coupling between CuI and CuII centers. Although electrocatalytic study with digenite Cu9S5 and covellite CuS ha...
Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes [0.03%]
原子水平解剖DC-SIGN识别Bacteroides vulgatus的LPS表位
Ferran Nieto-Fabregat,Qian Zhu,Corinne Vivès et al.
Ferran Nieto-Fabregat et al.
The evaluation of Bacteroides vulgatus mpk (BVMPK) lipopolysaccharide (LPS) recognition by DC-SIGN, a key lectin in mediating immune homeostasis, has been here performed. A fine chemical dissection of BVMPK LPS components, attained by synth...
Synthesis and Evaluation of (Bis)benzyltetrahydroisoquinoline Alkaloids as Antiparasitic Agents [0.03%]
(双)苄基四氢异喹啉生物碱作为抗寄生虫剂的合成与评估
Ana Sozanschi,Hannah Asiki,Maiara Amaral et al.
Ana Sozanschi et al.
Visceral leishmaniasis and Chagas disease are neglected tropical diseases (NTDs) that severely impact the developing world. With current therapies suffering from poor efficacy and safety profiles as well as emerging resistance, new drug lea...
Electrical Conductivities and Conduction Mechanism of Lithium-Doped High-Entropy Oxides at Different Temperature and Pressure Conditions [0.03%]
不同温度和压力条件下锂掺杂高熵氧化物的电导率及导电机理研究
Meng Song,Xiaoliang Zhang,Shun Wan et al.
Meng Song et al.
Li-doped high-entropy oxides (Li-HEO) are promising electrode materials for Li-ion batteries. However, their electrical conduction in a wide range of temperatures and/or at high pressure is unknown, hindering their applications under extrem...
A Study on the Role of Electric Field in Low-Temperature Plasma Catalytic Ammonia Synthesis via Integrated Density Functional Theory and Microkinetic Modeling [0.03%]
集成密度泛函理论和微观动力学建模研究电场在低温等离子体催化氨合成中的作用
Ketong Shao,Ali Mesbah
Ketong Shao
Low-temperature plasma catalysis has shown promise for various chemical processes such as light hydrocarbon conversion, volatile organic compounds removal, and ammonia synthesis. Plasma-catalytic ammonia synthesis has the potential advantag...
Highly Sensitive Labeling, Clickable Functionalization, and Glycoengineering of the MUC1 Neighboring System [0.03%]
MUC1邻近系统的高灵敏度标记、可点击功能化及糖工程化
Gang Wang,Ying Chen,Yuan Wei et al.
Gang Wang et al.
This study introduces a novel wash-type affinity-primed proximity labeling (WAPL) strategy for labeling and surface engineering of the MUC1 protein neighboring system. The strategy entails the utilization of peroxidase in conjunction with a...